The #cytoskeleton contributes to abnormal genome-lamina interactions in LMNA-deficient cardiomyocytes. New study from Kaitlyn M. Shen, Parisha P. Shah, Rajan Jain @pennmedicine.bsky.social and colleagues: rupress.org/jcb/article/...

#Chromatin #epigenetics #Disease #lamin #laminopathies

Stevie Ray Vaughan - Austin City Limits 1983 Unedited Complete YouTube video by SRVBootlegs

The entire 1983 Stevie Ray Vaughan ACL concert has been uploaded. I've queued it up to start on "Tin pan Alley," but the whole thing is worth watching --- after you "like" this post, of course. 😃

youtu.be/MrbAaQ3BXgA?...

A Cytosine Deaminase–Based Genomic Footprinting Assay (cFOOT-seq) for Detecting Transcription Factor Occupancy

Work by Meng-Chen Yang, Ang Wu, Heng Wang, Xiaoyu Liu, Jiejun Shi, Shaorong Gao and Jia-Min Zhang at Tongji University.

#LifeSciences #Reproducibility #MolecularBiology

Submit to our Developmental Biology Special Issue - Receptor tyrosine kinase signaling in development!😎

Guest editors
Katherine Fantauzzo @fantauzzolab.bsky.social
Jennifer Fish

Deadline April 30th, 2026

@socdevbio.bsky.social

Linked here👇
www.sciencedirect.com/special-issu...

NIH Fellowship awards for FY2025 by race The NIH Data Book page reporting Research Project Grants (RPG) and Fellowship awards by race has been updated for FY2025. Completely unsurprisingly, despite the impression that may have been convey…

NIH Fellowship awards for FY2025 by race drugmonkey.wordpress.com/2026/03/19/n...

Looking forward to a great talk from UVA BME alum Dr. Monica Lee @navbo.bsky.social !

MitoTracker transfers from astrocytes to neurons independently of mitochondria The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...

⚡️We are excited to share a new paper from the lab by @drkhole.bsky.social in @cp-cellrepmethods.bsky.social - suggesting MitoTracker dyes are not a reliable tool for detecting intercellular mitochondrial transfer❗️ www.cell.com/cell-reports...

View from the outside of a glass building/research institute.

Night view of La Fontaine park with trees and lights covered in a blanket of snow.

Crew removing snow from a turbine on a jumbo jet.

Fun, but snow filled/delay riddled trip (on both ends) to visit with folks at the Montreal Heart Institue to talk about vascular anomalies. Great talks with faculty, students, and postdocs and some fantastic questions/ideas.

Visit our fully accessible journal archive, providing perpetual access to 34k articles from over a century of pioneering research in developmental biology, cell biology, comparative physiology and biomechanics, including work from 60+ Nobel Prize-winners bit.ly/3PfIjib

We've added two gnomAD coverage tracks on human hg38:

gnomAD v4 Exome Coverage — mean/median depth & sample % at 1X–100X thresholds across exome samples.

gnomAD v3 Genome Coverage — same metrics for 71,702 whole-genome samples.

Learn more at:
genome.ucsc.edu/gold...

Joshua noted that the number of applications in the data NIH released includes only applications that were discussed at study section. This is approximately 50% of the applications submitted.

I have estimated these numbers in a slightly more sophisticated way, but these are still estimates.

2/25

Indigenous echoes: Alaska’s stats on MMIP likely higher, according to study According to the Urban Indian Health Institute, the first recorded case of a missing and murdered Indigenous woman or girl was in 1943. Two-thirds of all the cases they gathered for a 2025 study were ...

Homicide is the 3rd-leading cause of death among American Indian/Alaska Native women and girls between the ages of 10 and 24, and fifth-leading cause of death among women between 25 and 34 years old. Learn more about the statistics of MMIWG in Alaska here: www.alaskasnewssource.com/2025/04/05/i... 🧵

“We can’t afford cancer research but $11 billion for one week of an absurd war is fine” is a hell of an argument

Preprint: A proteocistromic atlas of 216 human disease-relevant transcription factors
www.researchsquare.com/article/rs-8...

Temperature change from Wednesday to Thursday afternoon

DC pulled off a ridiculous weather flip: 86 Wednesday to as low as 33 with snow today.

53-degree drop is largest 24-hour fall on record at National. 77 today & 86 Wed are warmest same and prior day to snow accumulation, too.

Dulles also joined the history book with combo. More: cwg.live ❄️🔥

bedder-manuscript.v10 Bioinformatics, 2026, 0–0 doi: 10.1093/bioinformatics/xxxxx Advance Access Publication Date: DD Month YYYY Genome Analysis Genome Analysis bedder: flexible genome interval intersection with user-defi...

Brent Pedersen, Mitchell Vollger and I have "posted" our preprint of the manuscript describing bedder, a complement to the functionality of bedtools. The "preprint server" we have chosen is google docs because it was rejected by biorxiv.

docs.google.com/document/d/1...

In vivo-directed evolution identifies AAV-WM04 as a next-generation vector for potent and durable hearing restoration in DFNB9 www.biorxiv.org/content/10.64898/2026.03...

We just sent the March edition of our newsletter out to more than 1350 subscribers!

It covers our next webinar (which we are very very excited about), city and county budgets, IMPACT’s Nehemiah Action, opportunities to walk/run/bike/roll through Cville, and more!

mailchi.mp/livablecvill...

Obituary information for Sophia Elaine Burdine Schwartz View Sophia Elaine Burdine Schwartz's obituary, contribute to their memorial, see their funeral service details, and more.

Very sad news: Becky Burdine's 20-year old daughter Sophie passed away suddenly on Tuesday

Becky has been vocal about Sophie, is an @angelmanfoundation.bsky.social advocate, and wants her science/cilia/LR community to know

We love you @rburdine1.bsky.social

www.matherhodge.com/obituaries/S...

GetHIRED! REGISTRATION IS NOW OPEN - Application due Thursday, March 5 Ideal for Postdoctoral Researchers Academic Job Market Insight -Take stock of what you want -Know your options -Prepare outstanding job packet materials -Organize your research & chalk talks -Perfect your interview & avoid the pitfalls Course Features -Six asynchronous online modules -Virtual meetings with an experienced facilitator -Peer feedback, support, & expert advice Course Dates: April 14 – June 23, 2026 Course Fee: SDB Members: $499; Non-Members: $599 Deadline: March 5, 2025 Society for Developmental Biology logo QR Code for GetHIRED! website

#Postdocs! Going on academic job market? Apply for SDB GetHIRED! Take stock of what you want, know your options, prepare an outstanding job packet, organize your research & chalk talks, perfect your interview. Deadline: March 5 sdbonline.org/gethired

NIH FY2025 funding data finally emerges on RePORT The FY2025 funding picture was disrupted significantly by the mandate for Multi-Year Funding of about half of the budget for extramural awards. This produced a mid-year declaration by NCI that thei…

NIH FY2025 funding data finally emerges on RePORT drugmonkey.wordpress.com/2026/03/06/n...

Here is the "effective payline" for each institute, estimated (by Claude) as the percentile where one can expect 80% probability of funding from a logistic regression fit. The effective payline has gone from a historic ~12% to 6% in 2025.

Can a wealthy family change the course of a deadly brain disease? Inspired by the loss of their mother, they have poured millions into studying a key protein behind frontotemporal dementia. But all has not gone according to plan

Fascinating account of trying to find a cure for frontotemporal dementia (FTD): great advances in our understanding of one variant (mutations in GRN resulting in TDP43 proteinopathy) but no success yet with respect to treatment.

www.science.org/content/arti... #medsky

Genetically altered chimeric antigen receptor astrocytes targeting amyloid-β reduce a cardinal pathological feature of Alzheimer’s disease @science.org @washumedicine.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Just to see if I still could
Who have I become
Now gene synthesis is…..good?

4 corporate Democrats funded by AIPAC voted with MAGA to let Trump continue to wage illegal war on Iran.😐
•Henry Cuellar: 202-225-1640
•Jared Golden: 202-225-6306
•Greg Landsman:202-225-2216
•Juan Vargas: 202-225-8045

Call & remind them we reject their complicity in fascism

Jeffries should resign.

awesome @navbo.bsky.social webinar today from Dr. Sarah Sheppard at the NIH on lymphatic malformations!

a man in a suit and white shirt is sitting at a desk with a pen in his hand and says oh ! ALT: a man in a suit and white shirt is sitting at a desk with a pen in his hand and says oh !

A nice drizzle across the pie after baking to finish would be super I bet, or if indulgent use a thin layer across the dough as the sauce would probably taste awesome (for the above one I usually only put down olive oil as the sauce).

Bacon, mandolin thin cut potatoes (like for an au gratin), and extra sharp white cheddar is amazing. Just have to cook the bacon and roast the potatoes before putting the pie together and in the oven.