If after reading the article you are still hungry for more about alternative TREX-2 complexes, also check out the recent preprints from the labs of Torben Heick Jensen @heick.bsky.social and Mary Dasso 😉

www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.6...

An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA export Abstract. In eukaryotes, nuclear messenger RNA (mRNA) export is a crucial step in gene expression, mediated by the conserved mRNA exporter Mex67-Mtr2 in Sa

Very happy to share the paper on nuclear mRNA export by Nataliia Stefanyshena now out in #NAR! Nataliia uncovered that, counterintuitively, an excess of the conserved mRNA exporter Mex67 in yeast messenger ribonucleoprotein particles (mRNPs) impairs mRNA export.

academic.oup.com/nar/article/...

Tho1 and MOS11 promote nucleic acid double-strand unwinding by facilitating DEAD-box helicase oligomerization Abstract. DEAD-box helicases are essential for gene expression and RNA metabolism. However, the mechanisms regulating their activity remain largely elusive

Happy to share the work by Fabienne Becker et al in #NAR, showing how yeast Tho1-CTD stimulates helicase activity of Sub2, homologue of human DDX39B/UAP56, by promoting Sub2 oligomerization on RNA. The scaffolding mechanism is shared across species:

academic.oup.com/nar/article/...

Proud to bring together so many excellent invited speakers for our RTG 2355 International Conference next September, and looking forward to welcoming you @jlugiessen.bsky.social!
👉 tinyurl.com/rtg2355conf

And here goes another one - @rtg2355.bsky.social-member Fabienne Becker from the Friedhoff lab presented her research at the 2025 Helicase Conference in Lisbon today: "The Conserved C-terminal Domain of Tho1 Stimulates the DEAD-box Helicase Sub2" - more coming soon #proudCoordinator 😉

Palina Kot from @straesserlab.bsky.social recently gave a talk on her "Structural and Functional Insights into the Sub2-Yra1-Tho1 Complex in Nuclear mRNP Biogenesis" at the 2nd Polish RNA Biology Meeting in Poznan - #proudPI

Congratulations to our biochemistry professor Utz Fischer: he has been elected to @embo.org ! His research focuses on the macromolecular machines of the cell. 📷 Christoph Weiss www.uni-wuerzburg.de/en/news-and-...

What does it mean to be a woman in science 👩‍🔬?
It’s up to you: Join the 9th Women’s Careers and Networks symposium on June 4 and 5 on our Fassberg Campus to explore career opportunities and engage with experts and peers.

Learn more about #WoCaNet2025 here 👉 uni-goettingen.de/de/203891.html

The two talks were indeed a great start for a great meeting. I am looking forward to more to come!

Screenshot der JLU kiChat-Oberfläche.

KI? Aber sicher! Die JLU bietet Studierenden und Beschäftigten mit dem JLU #kiChat ab sofort die datenschutzkonforme Nutzung von #KI-Tools – Werkzeuge in drei verschiedenen Sicherheitsstufen – Keine Preisgabe individueller Nutzerdaten
www.uni-giessen.de/de/ueber-uns...

Doctoral student (m/f/d) in the field of RNA Biology

Interested in RNA biology, especially mRNA processing and export from nucleus to cytoplasm? We are looking for an enthusiastic PhD student to investigate the RNA-binding proteins Sub2 and Tho1 🧪🧫🔬

More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...

An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA export In eukaryotes, a crucial step in gene expression is the export of the mRNA out of nucleus. The conserved mRNA exporter Mex67-Mtr2 (NXF1-NXT1 in human) is a key factor in this process. In S. cerevisiae...

We are excited to share the work of Nataliia Stefanyshena who showed that maintenance of an optimal Mex67 level in nuclear mRNPs is required for efficient mRNA export: www.biorxiv.org/content/10.1...