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Liver metastases dampen IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer van Renterghem et al. investigate the impact of liver metastases on immunity in MMR-d/MSI-hi patients treated with ICB. They show that IL18 activates liver-derived Vδ1+ T cells and predicts ICB benefi...

Why do patients with liver metastases respond so poorly to cancer immunotherapy?
Here we find a new immunological mechanism in MMR-d cancers centering on IL-18 and γδ T cells.👇 www.cell.com/cell-reports... @cp-cellrepmed.bsky.social

Taking over the hospital for prideweek with gendercupcakes
@nkinl.bsky.social @florencevb.bsky.social #diversity

Drop by poster P-556 today between 18:30-20:00 and check out some of the first work of my PhD: “Trametinib for NRAS-mutated tumors: results from the Drug Rediscovery Protocol (DRUP)”. See you there! #EACR2025 👯‍♀️👩🏼‍🔬

Table of new drugs approved in Q1

FDA new drug approvals in Q1 2025 tinyurl.com/5n8ak54h

Only 7 new drugs were approved by the FDA in Q1, but 2 are potential blockbusters - the sodium channel inhibitor suzetigrine for pain and TROP2-targeted ADC datopotamab deruxtecan for breast cancer

Very inspirational two days at the Clinical Cancer Genomics conference in Amsterdam! Lots of interesting speakers on the current state of genomics and proteomics for biomarker identification and treatment decisions in daily oncological clinical practice. #CCG2025 #HartwigMedicalFoundation

Living alone for several years and/or experiencing serial relationship break-ups are strongly linked to raised levels of inflammatory markers in the blood–but only in men

jech.bmj.com/content/76/5...

Top 4 things to know about doing science:
1. You need to have someone you can talk to
2. One-on-one discussions are the best
3. Think about discussions as improvisations and use the ‘yes, and’ rule
4. Create a safe space so both of you feel open to saying seemingly silly things