Hmm, so we are one mutation from disaster ….

This is an amazing resource that helps take the guesswork out of buying antibodies!

Well worth a read

I’m taking the opposite view. I think the coercion issue can be dealt with by appropriate safeguards. I take the point re need for good palliative care, but there are still some grim conditions where even the best palliation can’t keep people comfortable. Personally I’d want it as an option.

Excited to share our latest findings on how the phosphoinositide PI4P pool at the trans-Golgi network (TGN) is regulated through a SYS1-ARFRP1-ARL5-ARMH3-PI4KB pathway, in which ARMH3 (also known as C10orf76) acts as an ARL5 effector to activate PI4KB. rdcu.be/d1dZ2

The ALS- and FTD-associated proteins Annexin A11 and CHMP2B act sequentially in membrane repair https://www.biorxiv.org/content/10.1101/2024.11.19.624330v1 Maintenance of plasma membrane and organellar integrity is essential for cell viability. Cells must

The ALS- and FTD-associated proteins Annexin A11 and CHMP2B act sequentially in membrane repair www.biorxiv.org/content/10.1101/2024.11....

Very interesting

Is he the St Edmund of Bury St Edmunds?

Axon Degeneration starter pack now updated. Plenty of room for more so give me a nudge if you’d like to be added.

This post is about a commentary that I wrote with Xin Yong about recognition of cargo vesicles by tethering factors involved in endosomes to TGN retrograde transport.

Development of optimised human iPSC-derived hepatocytes with improved liver function for in vitro metabolic disease modelling and toxicity studies https://www.biorxiv.org/content/10.1101/2024.11.18.624145v1 Background & Aims: Liver disease is a rising cause of mortality worldwide. Primary human hepatocytes

Development of optimised human iPSC-derived hepatocytes with improved liver function for in vitro metabolic disease modelling and toxicity studies www.biorxiv.org/content/10.1101/2024.11....

Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease There is growing evidence suggesting that the lysosome or lysosome dysfunction is associated with Alzheimers disease (AD). Pathway analysis of post mortem brain-derived proteomic data from AD patients...

www.biorxiv.org/content/10.1...

Mysterious. Sometime between the Euros in the summer and November 19th, Scotland seem to have become a decent football team 🤷‍♂️

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib

It’s not fantastic. Not a patch on the original