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Posts by Richard McCulloch

DNA damage drives antigen diversification in Trypanosoma brucei - Nature An in vitro toolkit for studying VSG diversification defines key molecular requirements underlying the formation of mosaic VSGs, providing an experimental framework for the exploration of antigen diversification in Trypanosoma brucei and in other pathogenic microorganisms.

Very happy to have contributed some confirmatory experiments to Jaclyn Smith and Monica Mugnier's excellent paper - out now @nature.com
www.nature.com/articles/s41...
@johnshopkinssph.bsky.social
@rmc9z.bsky.social

2 weeks ago 7 3 0 0
Logo for the 2026 BSP Spring meeting of buildings in Glasgow and parasites flying above them

Logo for the 2026 BSP Spring meeting of buildings in Glasgow and parasites flying above them

Our Spring meeting starts today in Glasgow! All the best to all those presenting @bspparasitology.bsky.social

2 weeks ago 8 7 0 0
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We are pleased to share a pre-print of collaborative work @scotomorph.bsky.social @janemunday.bsky.social @keithrmatthews.bsky.social @goldrieve.bsky.social describing the genome of Trypanosoma congolense and the organisation of VSG genes for immune evasion

www.biorxiv.org/content/10.6...

2 months ago 9 3 0 2

MPM 2026 will run from September 13-17 in Woods Hole, and applications are invited for LMIC travel awards. Have a go!

2 months ago 1 0 0 0
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Travelaward2026 MPM LMIC award details

🌍 Calling parasitologists from LMICs! Apply for the MPM XXXVII LMIC Travel Award to attend the Molecular Parasitology Meeting in Woods Hole, MA (September 13–17, 2026). Awards include full registration, travel, and accommodation.
🗓️ Deadline: March 1, 2026

🔗 www.parasitesrule.com/mpm-xxxvii/t...

2 months ago 7 7 1 2
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ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major Author summary A series of protein kinases act at the pinnacle of eukaryotic cells’ DNA damage response, organising and guiding repair. One such kinase is ATR, which recognises single-stranded DNA for...

I am trilled to share my latest publication where we contribute to the knowledge of how ATR kinase, a DNA damage response factor, modulates DNA replication timing during stress in Leishmania major.

Huge thanks to @rmc9z.bsky.social, @LuizTosi and the collaborators for the support and guidance!

4 months ago 8 3 0 0

Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications.

Join us at 12 noon on Thursday 14th November!

Register at docs.google.com/forms/d/e/1F...

5 months ago 4 5 0 0
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Animal Biology in Health & Disease - James Cotton

We have a PhD position in population genomics of sheep scab mites available from October 2026. The project will investigate Psoroptes populations in the context of eradication programs on Scottish island groups and spreading drug resistance. www.gla.ac.uk/postgraduate...

6 months ago 4 3 1 1
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Glenn A Burley

I'm also co-supervising a few other projects:
#1: an inter-disciplinary project on chemical biology of Base-J in kinetoplastids, led by Glenn Burley @Strathclyde. We aim to develop some new chemical approaches and apply them to study kinetoplastid genetics.
www.gla.ac.uk/postgraduate...

6 months ago 5 1 0 0
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University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Understanding Pathogens, from Molecules to Phenotypes - Richard McCulloch

#2 - a project taking a comparative approach to DNA replication and plasticity/mutation in kinetoplastids, expanding work form the 'model' parasites to other kinetoplastid lineages, with Richard McCulloch and Sarah Allinson in Lancaster: www.gla.ac.uk/postgraduate...

6 months ago 3 1 0 0
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Understanding Pathogens, from Molecules to Phenotypes - Richard McCulloch

Our lab has two funded PhDs to start in 2026 via the NorthWestBio programme

Project details here
www.gla.ac.uk/postgraduate...
...and here
www.gla.ac.uk/postgraduate...

Application deadline is Nov 21st 2025; apply here:
www.gla.ac.uk/postgraduate...

6 months ago 10 5 0 0
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Caroline Dewar

🔬Fascinated by the unique mitochondrial biology that keeps deadly parasites alive?
🥼We have a fully funded NorthWestBio PhD just for you‼️
🌎 @blslancasteruni.bsky.social
📍Co-supervisor Kostas Tokatlidis @uofglasgow.bsky.social
⏰Deadline 21st Nov
📮Info and to apply👇
www.gla.ac.uk/postgraduate...

6 months ago 2 4 1 0
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Happy to share our latest preprint, where we present a novel high-throughput #single-cell DNA method that resolves genomic heterogeneity in #Leishmania, from #aneuploidy, #CNVs to #drug-resistance mutations.

🧵...

Link here: www.biorxiv.org/content/10.1...

7 months ago 5 3 1 0
Illustrated logo for BSP Glasgow 2026. The image features detailed black-and-white line drawings of iconic Glasgow landmarks and parasitic organisms. In the center is the University of Glasgow’s main tower. Surrounding it are illustrations of parasites, including helminths, protozoa, and kinetoplastids. On the left is the SEC Armadillo building, and on the right is the Finnieston Crane. Bold text beneath reads: "BSP GLASGOW 2026".

Illustrated logo for BSP Glasgow 2026. The image features detailed black-and-white line drawings of iconic Glasgow landmarks and parasitic organisms. In the center is the University of Glasgow’s main tower. Surrounding it are illustrations of parasites, including helminths, protozoa, and kinetoplastids. On the left is the SEC Armadillo building, and on the right is the Finnieston Crane. Bold text beneath reads: "BSP GLASGOW 2026".

📆 | Save the Date!

The @bspparasitology.bsky.social Spring Meeting 2026 is coming to @uofglasgow.bsky.social.

Running from 7-9 April, there will be 15 sessions, 5 workshops, a ceilidh, a dinner - and a welcome reception at Glasgow City Chambers.

🔗 More info soon at bsp.uk.net/Events

7 months ago 9 6 0 0
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@scotomorph.bsky.social @uofgsii.bsky.social presenting new insights into Trypanosoma congolense at #Eukaryotes25 @microbiologysociety.org

7 months ago 12 2 1 0
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@marquescata.bsky.social @uofgsii.bsky.social presenting new findings on stable polyploid Trypanosoma brucei at @microbiologysociety.org #Eukaryotes25

7 months ago 14 2 1 0
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Assistant Professor (Research and Education) in Bacterial Genomics at University of Birmingham Looking for a new job opportunity in academia? Check out this job opening for a Assistant Professor (Research and Education) in Bacterial Genomics on jobs.ac.uk!

Reminder that we are recruiting an Assistant Professor Bacterial Genomics @imibirmingham.bsky.social.

www.jobs.ac.uk/job/DOO184/a...

Deadline 24 Sept.

7 months ago 18 28 0 0
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Did you submit an abstract to #mpm2025? Notifications went out this week. Check you spam folders if you don't see an email in your inbox. @rmc9z.bsky.social @mjgubbels.bsky.social @omarharb.org

8 months ago 5 4 0 0
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Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania m…

We’re pleased to share our new study, led by @jezieldamasceno.bsky.social, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers @uofgsii.bsky.social

www.sciencedirect.com/science/arti...

8 months ago 20 8 0 0

@gabriel93dasilva.bsky.social @marquescata.bsky.social @scotomorph.bsky.social @rmc9z.bsky.social @uofglasgow.bsky.social

Big thanks to Mike Boemo

8 months ago 1 1 0 0
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Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent.
We show widespread stochastic origin firing and insights into genome variability.

www.cell.com/cell-reports...

8 months ago 19 7 1 0

The anticipation is over, the MPM registration and abstract submission is open!!

10 months ago 10 4 0 0

We hope to see you at MPM in Woods Hole this year (again, or for the first time): registration and abstract submission is now open!

10 months ago 10 3 0 0
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Registration and Abstract submission for MPMXXXVI are now open! Abstract submission deadline is June 27th, get yours in quickly. @rmc9z.bsky.social @mjgubbels.bsky.social @omarharb.org
🔗https://www.parasitesrule.com/mpm-xxxvi

10 months ago 21 16 0 3
Research Group Leaders – GIMMResearch Group Leaders – GIMM Thank you very much for your generous donation and for sharing your testimony.We hope to more people feel inspired to join this mission of discovery and innovation!

The Gulbenkian Institute of Molecular Medicine (GIMM) is one of the best research institutes in Portugal. It's currently recruiting for three Group Leaders (junior or senior) across different areas, including systems biology and bioinformatics.
gimm.pt/jobs/open-ca...

11 months ago 43 58 0 0
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Early Career Summer Conference 2025

Abstract submission is open for the @microbiologysociety.org Early Career Summer Conference in Newcastle (23rd and 24th June). This is always a fantastic event, with a mix of talks, posters and professional development sessions. Abstract deadline 4th May.
microbiologysociety.org/event/societ...

11 months ago 8 5 0 0
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GRiP-ing Crypto talk tomorrow from Mattie Pawlowic from the University of Dundee. Join us!
2 pm (GMT) | 3 pm (CET) | 9 am (EDT)
Link- uofglasgow.zoom.us/j/8172068584...
Passcode: 038661

11 months ago 18 6 1 2
UK DNA Replication Meeting 2026 Research in the DNA replication field is progressing at a remarkable rate. Technological innovations in biochemical reconstitution, structural biology, proteomics and DNA sequencing are helping to rap...

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿

www.biochemistry.org/events-and-t...

1 year ago 22 16 0 0
Professor Lilach Sheiner pictured in the lab holding the C.A. Wright medal in an open presentation case.

Professor Lilach Sheiner pictured in the lab holding the C.A. Wright medal in an open presentation case.

🏅 | @uofgsii.bsky.social's Professor Lilach Sheiner (@sheinerlab.bsky.social) was recently awarded the prestigious C.A. Wright Medal by the @bspparasitology.bsky.social for outstanding contributions to the discipline.

Congratulations, Professor Sheiner!

🔗 Full story: www.gla.ac.uk/schools/infe...

1 year ago 76 16 9 2
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Uncovering the adaptation mechanism that generate dormant forms of Leishmania microbes with omics approaches at Newcastle University on FindAPhD.com PhD Project - Uncovering the adaptation mechanism that generate dormant forms of Leishmania microbes with omics approaches at Newcastle University, listed on FindAPhD.com

Funded PhD project with myself, Prof. Paul Denny at Durham University and Dr Kalesh Karunakaran at Teeside University now open for applications!

www.findaphd.com/phds/project...

1 year ago 8 7 0 2