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Posts by Thomas Hitchcock

Thrilled to present our comparative study on the evolution of zygotic genome activation (ZGA)!! 🥚🧬

Amazing PhD work of @campobes.bsky.social together with @fedemantica.bsky.social and many collaborators! @melisupf.bsky.social @crg.eu. Thread below 1/15

www.biorxiv.org/content/10.6...

1 day ago 112 55 4 9
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Join our Cloud HD Video Meeting Zoom is the leader in modern enterprise cloud communications.

Join our online seminar on April 15, 2026, at 10:00 UTC, featuring talks on genome defense and intragenomic conflict. Details: https://georgetown.zoom.us/j/97210197821?jst=2 More info: https://internalconflictsstn.wordpress.com/ #conference

1 week ago 1 1 0 0
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An insect that cooperates like bacteria | PNAS An insect that cooperates like bacteria

An insect that produces a nasty secretion to defend the local group against predators. Our commentary on some brilliant fieldwork by @caritalindstedt.bsky.social & Raphael www.pnas.org/doi/10.1073/... @asgriffin.bsky.social

2 weeks ago 16 2 0 0
Fig. 1.Stages of development for a seed with a nuclear-type transient endosperm. (A) A typical Polygonum-like mature ovule contains two gametes, the central cell and egg cell (E.C.), which are accompanied by two synergids and three antipodal cells. These gametophytic cells are surrounded by two integuments, inner (i.i.) and outer (o.i.). (B) Following double fertilization, two products start developing, the embryo and the endosperm. The latter initially develops as a coenocyte, where karyokinesis is uncoupled from cytokinesis, and a large vacuole occupies the center. The seed coat develops from the integuments and protects the fertilization products. (C) Later in development, the coenocytic endosperm cellularizes, after which it starts being consumed by the embryo. (D) In species with transient endosperms, like Arabidopsis, the embryo consumes almost the whole of the endosperm, leaving a single cell layer called aleurone.

Fig. 1.Stages of development for a seed with a nuclear-type transient endosperm. (A) A typical Polygonum-like mature ovule contains two gametes, the central cell and egg cell (E.C.), which are accompanied by two synergids and three antipodal cells. These gametophytic cells are surrounded by two integuments, inner (i.i.) and outer (o.i.). (B) Following double fertilization, two products start developing, the embryo and the endosperm. The latter initially develops as a coenocyte, where karyokinesis is uncoupled from cytokinesis, and a large vacuole occupies the center. The seed coat develops from the integuments and protects the fertilization products. (C) Later in development, the coenocytic endosperm cellularizes, after which it starts being consumed by the embryo. (D) In species with transient endosperms, like Arabidopsis, the embryo consumes almost the whole of the endosperm, leaving a single cell layer called aleurone.

🌾🔍 SPECIAL ISSUE REVIEW 🔍🌾

Understanding the interactions between embryo, endosperm, and seed coat is essential for both advancing our fundamental understanding of seed development and improving agronomic seed traits - Figueiredo & Sharma

🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪

2 weeks ago 10 8 1 0
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Explore the implications of within-organism conflicts for organismal biology at our upcoming workshop, ‘Internal Conflicts and Organismal Adaptation: Mathematical Foundations!’

Travel applications are due Wednesday, April 15th

www.nitmb.org/internal-con...

3 weeks ago 6 5 0 0
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Final version just published of our review on the ecological and evolutionary consequences of cooperation www.journals.uchicago.edu/doi/10.1086/... @ryosukeiritani.bsky.social @annadewar.bsky.social @asgriffin.bsky.social @lauriebelch.bsky.social
@asn-amnat.bsky.social

1 month ago 31 20 0 1

Join us at the NITMB in Chicago next June to talk about internal conflicts! The workshop will feature tutorials, talks, and discussions. Funding is available to provide travel and lodging for some attendees (apply!).

1 month ago 5 4 0 0

A centromere but not just a centromere: structure and evolution of a selfish chromosomal supergene in monkeyflowers www.biorxiv.org/content/10.6...

1 month ago 8 2 0 0
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Evolution and mechanisms of atypical reproductive modes Evolution and mechanisms of atypical reproductive modes Monthly meetings to bring together researchers focusing on atypical reproduction and other non-mendelian transmission systems. The objective is to promote the exchange of ideas and feedback on conceptually similar questions approached with d...

Join our online series on atypical reproductive modes and non-Mendelian inheritance, Tuesdays at 3 p.m. CET. More info & sign-up: https://tinyurl.com/EvoRepro Best, Schwander Group, University of Lausanne. #conference

2 months ago 5 2 0 0
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@kztwyman.bsky.social & @andygardner.bsky.social mathematically connect the dynamics of natural selection to optimisation to provide formal justification for viewing obligately eusocial colonies as adaptive individuals in their own right—that is, superorganism:

doi.org/10.1093/jeb/...

4 months ago 16 6 0 0

Parent-offspring conflict over sex determination in non-Mendelian systems www.biorxiv.org/content/10.1101/2025.11....

4 months ago 5 3 0 0
Photo of Kalyani Twyman.

Photo of Kalyani Twyman.

Two other members of the research group have successfully made it to @eseb2025.bsky.social ahead of me.

Look out for @kztwyman.bsky.social, whose poster "A formal theory of group-level adaptation for obligate eusociality" (P01.068) is in this evening's session.

8 months ago 6 3 1 0
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Convergent evolution through independent rearrangements in the primate amylase locus Structurally complex regions of the genome are increasingly recognized as engines of evolutionary convergence due to their propensity to generate recurrent gene duplications that give rise to similar ...

Our latest preprint explores the evolution of the primate amylase locus, uncovering structural innovations, regulatory shifts and molecular convergence.
www.biorxiv.org/content/10.1...

8 months ago 26 12 1 0
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An Extension of Muller's Sheltering Hypothesis for the Evolution of Sex Chromosome Gene Content Abstract. The first influential hypothesis for sex chromosome evolution was proposed in 1914 by H. J. Muller, who argued that once recombination was suppre

Mrnjavac et al. reevaluate arguments against Muller's hypothesis, and find that they do not conclusively exclude a role for sheltering in sex chromosome evolution.

🔗 doi.org/10.1093/molbev/msaf177

#evobio #molbio

8 months ago 11 3 0 1
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Happy to share our latest article, led by Tee Muirhead, now out in PNAS! We report the evolutionary genomics of the newly discovered neo-sex chromosomes in Myzomela — involving translocation, inversions & degeneration on the neo-W. doi.org/10.1073/pnas...

8 months ago 6 2 0 0

Outreach volunteers sought! @imprintedgene.bsky.social and I will host “Breaking Bread: Exploring the Evolution of Amylase in humans” at Festa Major de Gràcia, Barcelona (16 Aug, 19:00). We need 1-2 volunteers (ES/EN) for visitor guidance and on-site translation. Please DM or email me if interested.

8 months ago 4 2 1 0
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Faster adaptation but slower divergence of X chromosomes under paternal genome elimination - Nature Communications X chromosomes evolve faster than autosomes, but confounding factors make this a difficult phenomenon to study. Utilising the unusual sex determination system of Sciaridae flies, this study finds a slo...

New paper: "Faster adaptation but slower divergence of X chromosomes under paternal genome elimination" (Open Access)

w/ Robert Baird, @imprintedgene.bsky.social‬, Jan Ševčík, Katy Monteith, @laurarossevo.bsky.social‬ & @ajmongue.bsky.social‬

www.nature.com/articles/s41...

‪@natcomms.nature.com‬

10 months ago 15 7 0 1

Talks by:

@tatianagiraud.bsky.social‬
Bo Xu
@vincentcastric.bsky.social
@wenjuanma84.bsky.social‬
Sha Sun
Pengfei Wu
Robert Baird
Jing Liu
@imprintedgene.bsky.social‬
Deborah Charlesworth

10 months ago 4 1 0 0
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The Tree of Sex consortium: A global initiative for studying the evolution of reproduction in eukaryotes Abstract. Reproduction is a fundamental aspect of life that affects all levels of biology, from genomes and development to population dynamics and diversif
11 months ago 5 2 0 0

Abstracts for @eseb2025.bsky.social due next week! Milk, ejaculates, skin secretions, regurgitate, microbes ...our symposium will have it all, with invited speakers @berasymbionts.bsky.social and @jennyperry.bsky.social ...and you?
Organised w/ @joriskoene.bsky.social and @wolfnerlab.bsky.social

1 year ago 10 5 0 1
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Now available for preorder!

The Paradox of the Organism:
Adaptation and Internal Conflict, edited by me and Manus Patten, will be published by @harvardpress.bsky.social this fall.

Cover coming soon.

1 year ago 26 9 2 1
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The man who sent Japan's cherry blossoms out to the world Masatoshi Asari's trees — symbols of peace and reconciliation — blossom in the U.K., U.S., Poland and China.

The man who sent Japan's cherry blossoms out to the world: "If my cherries can help spread some happiness and avoid war, then it’s all worthwhile, and I can sleep soundly."

1 year ago 196 49 3 2
Workshop II – INTERNAL CONFLICTS AND ORGANISMAL ADAPTATION Workshop II – INTERNAL CONFLICTS AND ORGANISMAL ADAPTATION

Registration is open for the Internal Conflicts STN Workshop at ESEB 2025 on August 17 in Barcelona. Free registration includes lunch. More info: https://internalconflictsstn.wordpress.com/workshop-ii/ #workshop

1 year ago 2 1 0 0

Ever wondered why you too should publish in @jevbio.bsky.social? Wonder no more, we have the answers for you (in case you didn’t know already):

1 year ago 11 10 1 0
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Cephalopod sex determination and its ancient evolutionary origin Octopuses, squids, and cuttlefishes—the coleoid cephalopods—are a remarkable branch in the tree of life whose members exhibit a repertoire of sophisti…

Octo-squid-nautiloid sex chromosomes!

www.sciencedirect.com/science/arti...

1 year ago 70 22 4 5
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The joint evolution of separate sexes and sexual dimorphism Abstract. Dioecious plants are frequently sexually dimorphic. Such dimorphism, which reflects responses to selection acting in opposite directions for male

1/7 Very happy to share our latest paper on the joint evolution of separate sexes and sexual dimorphism in @jevbio.bsky.social, led by @thomaslesaffre.bsky.social and in collaboration with John Pannell at @dee-unil.bsky.social

🔗 doi.org/10.1093/jeb/voae136

1 year ago 46 26 3 1
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Society for the Study of Evolution Site description

Undergraduate Diversity at Evolution provides full support— registration, travel, lodging, meals— and mentoring for students to attend the Evolution 2025 meeting in Athens, Georgia this summer! Applications are due Monday, submit yours here:

1 year ago 16 16 0 0
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New paper: "Kin competition drives the evolution of earlier metamorphosis", with @bingdongevo.bsky.social.

doi.org/10.1002/ece3...

1 year ago 12 5 0 0
John Werren (University of Rochester): Cooperating on Conflict: Selfish Genetic Elements, Heritable Microbes, and Genetic Conflicts.
Bengt Olle Bengtsson (Lund University): Decades of conflicts: A personal history.

John Werren (University of Rochester): Cooperating on Conflict: Selfish Genetic Elements, Heritable Microbes, and Genetic Conflicts. Bengt Olle Bengtsson (Lund University): Decades of conflicts: A personal history.

*Internal Conflicts and Organismal Adaptation*

Join us on Thursday, 9am Eastern, for a history special in our STN lecture series!

Jack Werren and Bengt Olle Bengtsson will reflect on their many years of working on genetic conflicts.

1 year ago 9 6 1 1
Graphical abstract of the methods and main results of the publication. It includes a photograph of a group of several humpback whales competing to be closest to the female of the group.

Graphical abstract of the methods and main results of the publication. It includes a photograph of a group of several humpback whales competing to be closest to the female of the group.

New paper on "Patterns of paternity: insights into mating competition and gene flow in a recovering population of humpback whales." 🐋🧬
royalsocietypublishing.org/doi/10.1098/...

@emma-carroll.bsky.social @lrendell.bsky.social @ellengarland.bsky.social @seamammalresearch.bsky.social 1/8

1 year ago 58 23 5 5