Molecular basis of human GABA transporter 3 inhibition Nature Communications - GABA transporters maintain GABA homeostasis and regulate synaptic signaling. Here, the authors determined the cryoEM structures of GABA transporter 3 (GAT3) in its apo form...

I'm excited to share our lab's newest publication on the structure and pharmacology of human GABA transporter 3 @natcomms.nature.com. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. 💊 🧪 #CryoEM #OpenAccess rdcu.be/ei2KY

Thanks Fluorescence Society and IIT Bombay for the great conference. And thanks Arindam Chowdhury for being such a gracious host!

An infrared photo of a rainbow: a strange, ghostly-looking rainbow in a mostly black and white photo, with a faintly red outer edge and a cyan inner edge, and what look like a few even fainter ‘echo’ bows inside

A regular visible-light pic of a rainbow

An ultraviolet picture of a rainbow: a dark, foreboding landscape with a deep purple stripe emanating from it, and a grey stripe inside

A composite of the three preceding photos, showing that the infrared bow is ‘outside’ the visible light rainbow, and the ultraviolet bow ‘inside’

There’s more to rainbows than the human eye can see: here’s how a rainbow extends into the infrared and ultraviolet.

Photos:
1. Infrared
2. Visible (obviously)
3. Ultraviolet, and
4. A composite showing how UV is beyond the violet in a rainbow, and IR beyond the red end.

🧪 #photography

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