An image of C. elegans hermphrodite gonad, with DAPI stain in cyan and PH-3 immunofluorescence in red.
My lab released a new preprint today. The work is the culmination of a long term project led by Peren Coskun, Ph.D., who investigated the biological role of the C. elegans glp-1 3'UTR in its endogenous context. Please join me in congratulating Peren!
www.biorxiv.org/content/10.6...
Please register at this link: forms.office.com/Pages/Respon...
The RNA Society and the Alliance for mRNA Medicines (AMM) are collaborating on communication and advocacy training for members. Please fill out this form if you would like to attend on March 6, 2:00-3:00pm ET.
forms.office.com/Pages/Respon...
Sean Ryder, PhD, spoke with Worcester Magazine about RNA therapeutics and how they may treat a wide variety of health conditions in the future and the quest to separate facts from misconception: direc.to/oinD
#RNA @seanryderphd.bsky.social @rti-umasschan.bsky.social @worcestermagazine.bsky.social
I am grateful to share that the latest research paper from the lab is now published in RNA. This work was a wonderful collaboration with Francesca Massi’s lab. Please join me in congratulating co-first authors Asli Ertekin and Sharon Noronha.
rnajournal.cshlp.org/content/31/1...
Thanks Aaron!
A professor stands at a podium in a Universalist Church, speaking to audience members in the pews.
The cover of a book titled Everyday RNA: The future of RNA medicine. The cover is pink with a single stranded nucleic acid cartoon.
The professor signing a copy of his book at a podium in a church.
A projected image on a TV screen of the title slide that reads "GAIN presents "From Cows to COVID (And Beyond): A brief history of vaccines" by Sean P. Ryder, Ph.D.
I gave a public educational seminar on the history of vaccines yesterday sponsored by @gain-indivisible.bsky.social. I encourage all scientists to give public educational seminars a shot. You’ll learn something and you will be surprised (in a good way) by the people you meet.
My son (the wizard), myself, and @repmcgovern.bsky.social at the #Worcester #NoKings rally put on by @gain-indivisible.bsky.social. It was a glorious day to fight the power with my people. Representative McGovern is my guy, 100%. He shows up and he tells it like it is.
Figure 5: Germ layer patterning defects in the mex-3 Δ3′UTR mutant. (A) mex-3 RNAi results in dead embryos with a large expansion of muscle lineage cells (mesoderm, yellow). Control animals develop normally, with all three germ layers present and appropriately patterned. Cytoplasmic (C) green represents GFP::MEX-3 protein, nuclear (N) green indicates endoderm, nuclear (N) yellow indicates mesoderm and nuclear (N) red indicates ectoderm. (B) At elevated temperature, the mex-3 Δ3′UTR mutants form all three germ layers, but patterning appears defective with a moderate expansion of muscle lineage cells (yellow). (C) Fraction of embryos that appear normal versus abnormal binned as in Fig. 4. The genotype and the temperature of growth are shown. CTL is a control for the germ layer background (strain OD1854). All sample sizes and statistical test outcomes are listed in Table S3. Scale bars: 10 μm.
MEX-3’s untranslated region helps worms beat the heat
This Research Highlight showcases the work from Sean Ryder (@seanryderphd.bsky.social) and colleagues:
journals.biologists.com/dev/article/...
Sean Ryder and research group, including first author Hannah Brown. Picture shows seven people with their hands up and/or doing jazz hands in a hallway.
To learn more about this work and the people behind it, we spoke to first author Hannah Brown and corresponding author Sean Ryder @seanryderphd.bsky.social, Professor and Vice Chair for Outreach, Biochemistry and Molecular Biotechnology @umasschan.bsky.social
journals.biologists.com/dev/article/...
Help protect our hard-working federal employees at the NIH
I am not ok with this
Copies of "Everyday RNA" are arriving in the US. I ordered 30 copies—they arrived at my house yesterday. If you haven't pre-ordered a copy, your best bet is to order directly from World Scientific Press . The online retailers won't get them until later.
www.worldscientific.com/worldscibook...
Amazon Rankings:
#1 New Release in Biotechnology (#3 overall)
#2 New Release in Medical Research (#25 overall)
#3 New Release in Genetics (#10 overall)
I have been assured by the publisher that it will be available in the first week of October.
Thank you all for pre-ordering!
everydayrna.com
In 2013, my father lost his life to multiple myeloma. Now, a variety of new treatment options are extending myeloma patient lives for years if not decades. It's been amazing to watch. Support the the NIH, fight back against RFK, and protect academic research.
www.fastcompany.com/91388585/
There’s a book from political scientists Macedo and Lee that claims the COVID-19 pandemic was not as much of a threat to public health as was supposed, calling into question the role of expertise.
Here, an excellent corrective to that erroneous position:
joshuasweitz.substack.com/p/revisionis...
Newsweek is reporting the RFK plans an outright ban on mRNA vaccines in the United States within a few months. That's a huge mistake. Please, speak out against those who would derail the most promising technology to curb virus spread since Charles Maitland and cow pox.
Thanks Aaron! I hope you enjoy it!
A book cover with a strand of RNA on a pink background, with the title, authors name, and publisher.
I did a thing. I wrote a textbook about #RNA. I wrote it so that those without formal science training could understand what RNA is and how it is used in medicine. It releases in the US and Europe on September 8th. www.worldscientific.com/worldscibook...
Horrible news!
Very timely review for those of you who have been following all of the recent developments in this area... also @cp-trendsbiochem.bsky.social why can't we share via bsky directly from the article???
Sounds like another nazi to me.
www.state.gov/releases/off...
To facilitate this vetting, all applicants for F, M, and J nonimmigrant visas will be instructed to adjust the privacy settings on all of their social media profiles to “public.”
I am not ok with this!
Hi, it’s Meg again. Brad is still in ICE custody.
We are grateful to the many friends, supporters, and allies who have gathered in Federal Plaza.
Together we are standing up for those with no voice.
Hi, this is Meg Barnette, Brad's wife.
While escorting a defendant out of immigration court at 26 Federal Plaza, Brad was taken by masked agents and detained by ICE.
This is still developing, and our team is monitoring the situation closely.
Grateful to share a microphone and a stage with one of the very best Congresspersons in the nation, @repmcgovern.bsky.social! This was at the #Worcester #NoKings rally. 2000+ energized attendees at the rally behind city hall. #GAIN
Just get rid of this guy already. I'm sick of his face.
Tomorrow we stand together. We stand for democracy. We stand for basic human decency. We stand so that our great Republic will not fall.
We need you. We need ALL of you. Stand with us. Together we are Indivisible. Together we will have liberty and justice for all
www.facebook.com/share/1AE97P...
Longer video of the forcible removal, detainment, and arrest of Sen. Alex Padilla by the Trump regime during a DHS press conference. Footage provided by Sen. Padilla's team.
IYKYK
