Controlled colonization of the human gut with a genetically engineered microbial therapeutic Precision microbiome programming for therapeutic applications is limited by challenges in achieving reproducible colonic colonization. Previously, we created an exclusive niche that we used to engraft...

Engineering the gut microbiome in people with hyperoxaluria to avoid kidney stones
science.org/doi/10.1126/...
@science.org

Thanks @martinpacesa.bsky.social! BindCraft definitely works great and can't wait to test it on some other targets we have in the pipeline.

Very happy to share our preprint on heavy metal associated (HMA) domain-containing rice proteins bound by the rice blast MAX effector AVR-Pia! 🌾

You designed binders for your favourite protein and wish there was a way to experimentally screen them within 24h w/ only a set of pipettes and a plate reader?

Check out our Cell-Free 2-Hybrid approach (CF2H)

Full post: tinyurl.com/48cz5nb6

Preprint: www.biorxiv.org/cgi/content/...

#MicroSky: Biosensors in GLOBAL HEALTH: Microbial biosensors offer cost-effective & sensitive tools for environmental risk analysis and early disease detection & monitoring. A leap toward sustainable health solutions! Discussed by Capin et al. Read here: https://buff.ly/3OI1UUQ

We updated our BindCraft preprint with lots of new exciting results! We release all our binder sequences and models, include more in silico analysis, novel design targets, and present AAV retargeting to specific cell types using de novo binders!
www.biorxiv.org/content/10.1...

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Hello Bluesky !
Introducing the Centre de Biologie Structurale (CBS), a research lab of around 150 people, located in Montpellier, South of France 🔆.
Our 12 teams develop and use new technologies in structural biology, single molecule biophysics and synthetic biology to tackle biological questions.