Good summary of the marked benefit of the molecular glue drug (daraxonrasib) vs pancreatic cancer, from Revolution Medicines, and other progress (adds to the neoantigen vaccine with 6-year survival)
gift link wsj.com/opinion/revo...

Microplastics and nanoplastics were found in 100% of healthy brains, 99.4% of diseased brains, with much higher concentrations adjacent to brain tumors
nature.com/articles/s44...

The worst cancers with respect to lethality get the least federal funding support
jamanetwork.com/journals/jam...

Microbiome signature of Parkinson’s disease in healthy and genetically at-risk individuals - Nature Medicine Microbiome analysis suggests that gut microbial changes in Parkinson’s disease evolve progressively from healthy individuals to genetically at-risk individuals to clinically affected patients, with th...

We've known the gut-brain axis is a key underpinning of Parkinson's disease. Today, for the 1st time, a gut microbiome signature denoting risk found in healthy individuals with genetic predisposition

nature.com/articles/s41...

some data on the shrinkage

That's right....and so dreadfully wrong
www.washingtonpost.com/science/2026...

The Infinity Machine A NYT Bestseller and masterpiece on how AI Grew Up by Sebastian Mallaby

How did AI grow up over the past 15 years? The riveting story is expertly told in this exceptional new book THE INFINITY MACHINE by Sebastian Mallaby. Here is the link to our conversation
erictopol.substack.com/p/the-infini...

Simple answer. No.
scientificamerican.com/article/the-...

I enjoyed seeing some Super Agers share their experiences

A look at 'super agers' and the science behind longer, sharper lives - Horizons For thousands of years, humans have tried to avoid growing old. Billions are spent every year on potions and procedures to make us look younger, feel younger and think younger. It’s a hugely profitabl...

At @pbs.org last night, a segment on Super Agers
@pbsnews.org www.pbs.org/newshour/vid...

Did you know immune systemB cells are essential for exercise performance?
Learning from B cell deficiency in the mouse model
cell.com/cell/fulltex...

Full text

What to Know About the Cicada SARS-CoV-2 Variant This JAMA Medical News article discusses the unusual trajectory of BA.3.2, the most recent version of SARS-CoV-2 to be designated a Variant Under Monitoring by the World Health Organization.

Everything known about the hyper-mutated BA.3.2 variant ("Cicada") of #SARSCoV2. While there's no cause for alarm, continued genome surveillance of this virus is essential.
jamanetwork.com/journals/jam...

Eradicating tumors with a mRNA vaccine in the experimental model
www.pnas.org/doi/10.1073/...

Genome editing of blood stem cells to make therapeutic antibodies on demand!
+ applications for programming a factory of other proteins
New @science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...

FDA panel will meet to discuss allowing broader access to certain peptides The FDA will convene an outside panel of advisers to discuss whether to allow compounding pharmacies to manufacture certain peptides

On this Peptide Panel at FDA
My input: "“I just hope the committee does the right thing and does not lift the ban on these peptides for compounding in the U.S. given their vacuous data for safety and efficacy,."

www.statnews.com/2026/04/15/p...

How did COVID mRNA vaccines improve favorable responses and patient outcomes for cancer immunotherapy?
www.nature.com/articles/s41...
A new report today on the priming of CD8+ T cells by these vaccines, a likely explanation
www.nature.com/articles/s41...

That's right. Inflammation is the big miss for getting ahead of coronary artery disease
scientificamerican.com/article/new-...
My review of this big shift
erictopol.substack.com/p/the-big-sh...

Thanks Eric! I worked to make this review of human immune memory to vaccines comprehensive and accessible. And I made an accompanying video lecture for those desiring a different format:
www.youtube.com/watch?v=8DeZ...

Agree. There are plenty of bad medical terms that need renaming, like "heart failure" and "geriatric pregnancy"
gift
wsj.com/opinion/why-...

The capacity of vaccine induced immunological memory, a stellar open-access review by @profshanecrotty.bsky.social www.cell.com/immunity/ful...

The turning point for rare diseases, which affect >300 million people around the world.
A call to get rid of its many structural obstacles, to consider it as molecular surgery unlike drug treatments
gift link:
www.nytimes.com/2026/04/09/o...

Thank you!

Trisha Pasricha: How to Get to Poophoria, Making Your Bowel Movements a Joy! Dr. Trisha Pasricha has the answers and a new book

Anyone with bowel movements and gas will find this conversation with Dr. Trisha Pasricha fun and very informative!
erictopol.substack.com/p/how-to-get...

Good on @pauloffit.bsky.social
www.phillymag.com/news/2026/04...

That's not what the evidence shows. And it's compelling.
You do you.

Full text if access is an issue

Mammography should include artificial intelligence support In the past decade, deep learning has increasingly been applied to medical image interpretation, but without consensus as to whether medical practice should change. Many studies show artificial intelligence (AI) enhanced accuracy beyond the performance of radiologists. The most compelling evidence comes from the follow-up of the Mammography Screening with Artificial Intelligence (MASAI) randomised trial, which assessed the reading of two radiologists compared with one radiologist plus an AI algorithm.

Every mammogram should be supported by 3 different AIs for improved detection of cancer, prevention, and risk of heart disease. At no cost to patients.
My new @thelancet.com essay reviews the evidence and the lack of implementation
thelancet.com/journals/lan...

A new feature @science.org on the clusters of cells that enhance the spread of cancer, and what can be done to break them up
www.science.org/content/arti...

Pathetic.
gift link
wapo.st/4ccudpF