Bridging the lipid divide: archaeal ESCRT-III binds phosphoinositol and polarises the cytokinetic membrane www.biorxiv.org/content/10.6...

Design principles of human membrane protein topology www.biorxiv.org/content/10.6...

Dynamic blebbing and absence of organelle transfer during mouse oocyte formation - The EMBO Journal Oocyte formation in mammals is a tightly regulated process essential for female fertility, yet the underlying mechanisms remain poorly understood. In this study, we establish an ex vivo culture system...

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PEX11 mediates intralumenal vesicle formation in peroxisomes - Nature Communications PEX11 is implicated in peroxisome division. Here, the authors uncover additional membrane-shaping roles for Arabidopsis PEX11 isoforms, including restraining peroxisome size via the formation of intra...

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A high-resolution spatial map of cilia-associated proteins in the human fallopian tube - Nature Communications Molecular changes in ciliated cells of the fallopian tubes play a crucial role in the development of cancer and reproductive disorders. Here, the authors spatially characterize 133 proteins at a subce...

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Happy Golgi Day

Saturated cardiolipins are potent disruptors of inner mitochondrial membrane structure and function www.biorxiv.org/content/10.6...

Lipids Regulate Export of Lysosomal Enzymes from the Endoplasmic Reticulum www.biorxiv.org/content/10.6...

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The revised three-step detour pathway in dolichol biosynthesis is evolutionarily conserved in budding yeast

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis - Nature Cell Biology Liu, Gad et al. develop an approach to purify the endoplasmic reticulum and integrate genetic, structural, molecular and cell biological analyses to identify SLC33A1 as an endoplasmic reticulum oxidiz...

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GPI lipid remodeling regulates lipophagy by forming lipid domains in response to glucose deprivation www.biorxiv.org/content/10.6...

Palmitoylation of Tspan4 is essential for migrasome formation Wang et al. show that migrasome formation requires tetraspanin 4 palmitoylation regulated by DHHC6 and PPT1. This modification drives tetraspanin 4 cluster

Palmitoylation of Tspan4 is essential for migrasome formation rupress.org/jcb/article-...

Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress www.biorxiv.org/content/10.6...

Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from parkinsonism to perinatal lethality
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Sorcin couples Annexin A11 recruitment and ESCRT-III assembly during plasma membrane repair www.biorxiv.org/content/10.6...

SREBP governs a triglyceride:glycogen metabolic switch in Drosophila www.biorxiv.org/content/10.1...

Lipid-trap mass spectrometry identifies lipid–protein interactions in cells - Nature Cell Biology Paquola et al. present a technique named lipid-trap mass spectrometry (LTMS) to study lipid–protein interactions directly captured from mammalian cells.

Lipid-trap mass spectrometry identifies lipid–protein interactions in cells
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ER-derived caveolin-coated vesicles transport newly synthesized cholesterol to the plasma membrane Newly synthesized cholesterol is transported from the endoplasmic reticulum to the plasma membrane via specialized COPII-independent vesicles. This process

ER-derived caveolin-coated vesicles transport newly synthesized cholesterol to the plasma membrane url: rupress.org/jcb/article-...

The molecular basis of tricalbin-mediated membrane contact site organization in cells Membrane contact sites facilitate molecular exchanges through physical interactions between organelles, connected by specific protein tethers. Among these tethers are the tricalbins, which mediate con...

The molecular basis of tricalbin-mediated membrane contact site organization in cells url: journals.biologists.com/jcs/article-...

A lineage-specific selective autophagy receptor module mediates P-body turnover: Developmental Cell www.cell.com/developmenta...

GTPase-activating protein DLC1 spatio-temporally regulates Rho signaling doi.org/10.7554/eLif...

Translation in proximity to forming autophagosomes during sustained autophagy
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How endosomal PIKfyve inhibition prevents viral membrane fusion and entry www.biorxiv.org/content/10.1...

The reticulon homology domain of Pex30 generates membrane curvature at ER subdomains for lipid droplet biogenesis www.biorxiv.org/content/10.6...

Lysosome-related organelles orchestrate guanine crystal formation in pigment cells | PNAS www.pnas.org/doi/10.1073/...

Diffusive spreading across dynamic mitochondrial network architectures | PNAS www.pnas.org/doi/10.1073/...

The SWR1 complex prevents the vacuolar delivery of ATG proteins through a noncanonical pathway url: rupress.org/jcb/article-...

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Systematic analysis of RhoGAP expression and function in border cell morphology and migration