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Posts by Hussain Gilani

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Articles about Jared Kushner's diplomatic role with Iran that mention Kushner has received billions from the Saudi government (2/28-4/19):

NYT: 5 of 58
WashPost: 1 of 43
WSJ: 0 of 40
AP: 0 of 26
CNN Wire: 0 of 18
NY Post: 0 of 17
Chicago Tribune: 0 of 4
LA Times: 0 of 4
Boston Globe: 0 of 2

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How the Strokes ended their second Coachella set!
#TheStrokes #Coachella

2 days ago 2112 883 18 229
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Jeffrey Epstein’s Lawyer Announces He Feels Safer as a Republican

13 hours ago 487 75 43 5

That’s right

14 hours ago 3399 288 20 3

I need a comprehensive list of medications that impair creatinine excretion

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Following the publication of this study in JASN, there was an interesting correspondence (see Pabla et al JASN 2024 and authors reply Pyne et al JASN 2024). Pabla et al point out that the organic cation transporter 2 (OCT2, encoded by the SLC22A2 gene) is involved in the basolateral tubular uptake and subsequent secretion of creatinine. PPIs may inhibit OCT2 (Nies et al PLoS One 2011). So Pyne et al, in their reply, present some additional analyses that suggest that the effect of pantoprazole compared with placebo on rate of eGFR change was attenuated in patients who discontinued treatment before eGFR reassessment (−0.04 ml/min per 1.73 m2 per year, 95% CI, −0.26 to 0.17) compared with those who remained on treatment (−0.60 ml/min per 1.73 m2 per year, 95% CI, −0.85 to −0.34). This disparity could support a reversible effect of pantoprazole on eGFR, possibly due to inhibition of creatinine secretion, or reflect a dose-response or threshold exposure effect. 

The case for PPIs causing kidney churn becomes even more weaker. For a longer explanation, see Lonnie Pyne’s rounds here.

Following the publication of this study in JASN, there was an interesting correspondence (see Pabla et al JASN 2024 and authors reply Pyne et al JASN 2024). Pabla et al point out that the organic cation transporter 2 (OCT2, encoded by the SLC22A2 gene) is involved in the basolateral tubular uptake and subsequent secretion of creatinine. PPIs may inhibit OCT2 (Nies et al PLoS One 2011). So Pyne et al, in their reply, present some additional analyses that suggest that the effect of pantoprazole compared with placebo on rate of eGFR change was attenuated in patients who discontinued treatment before eGFR reassessment (−0.04 ml/min per 1.73 m2 per year, 95% CI, −0.26 to 0.17) compared with those who remained on treatment (−0.60 ml/min per 1.73 m2 per year, 95% CI, −0.85 to −0.34). This disparity could support a reversible effect of pantoprazole on eGFR, possibly due to inhibition of creatinine secretion, or reflect a dose-response or threshold exposure effect. The case for PPIs causing kidney churn becomes even more weaker. For a longer explanation, see Lonnie Pyne’s rounds here.

Do PPIs cause kidney damage?

Read an update at the bottom of our summary www.nephjc.com/news/compass...

#MedSky #NephSky #EMIMCC

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Why-dralazine?! Population risk of drug induced vasculitis — NephJC This week, we will discuss why a large registry cohort was needed to move past decades of scattered case reports and clarify the true risk of hydralazine‑associated vasculitis. When rare events hide i...

Do you prescribe hydralazine?
Or, do you 🛑 it as soon as you see it?
Hydralazine persists despite TID dosing & risks like... vasculitis 🔥
Are you asking Why-dralazine?
✅The blog by @dramiliflores.bsky.social @nephroseeker.medsky.social
#NephSky
www.nephjc.com/news/hydralazine-anca-vasculitis

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you could watch this happen live using ais tracking yesterday and you could almost hear the captains yelling leeeerrrrrooooooy jeeeeennnnnkiiiiiins

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ZOHRAN MAMDANI: "It is sad that for too many Americans when they want to look for ambition in the Democratic Party, they have to turn to a history book."

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Mount Shasta?

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10 years ago, Elisabeth Bik published a preprint heard around the world Elisabeth Bik If you are at all familiar with scientific sleuthing, you’re familiar with Elisabeth Bik. She is quoted so often in the mainstream media it is probably difficult to imagine a time bef…

Retraction Watch interviews Elisabeth Bik

Self recommending

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Bhattacharya killing one of the most promising technologies in a generation for improving health, treating disease, & preventing mass death from pandemics was unforgivable; this will be his legacy

I was interviewed about his lies about mRNA vaccines here: www.bioxconomy.com/modalities/e...

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Dr. Jay Bhattacharya treats rare, mild vaccine side effects as worse than death from COVID, 6-2021
Dr. Jay Bhattacharya treats rare, mild vaccine side effects as worse than death from COVID, 6-2021 YouTube video by Jonathan Howard

Hot dog guy meme

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Pancreatic cancer mRNA vaccine shows lasting results in an early trial Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later.

"Pancreatic cancer mRNA vaccine shows lasting results in an early trial: Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later."

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Dave Mathews in a keffiyeh holding up signs that say STOP THE GENOCIDE and STOP KILLING CHILDREN at a concert

Dave Mathews in a keffiyeh holding up signs that say STOP THE GENOCIDE and STOP KILLING CHILDREN at a concert

This is not a knock on DMB but if you had told me twenty years ago that Dave Mathews would be this outspoken on an issue that Radiohead completely shat the bed on, well... I would've been surprised!

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The US used to be Gavi’s largest funder—but last year RFK Jr suspended US funding to Gavi, falsely accusing Gavi of ignoring science & spouting entirely trumped-up, baseless accusations about the organization—an organization that estimates it has saved over 20.6 million lives since the yr 2000.

9/n

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It's crucial to remember that RFK Jr isn't just doing all he can to roll back vaccination & drive up childhood infectious diseases in the US but also WORLWIDE & he's especially targeting children in the lowest income countries

He has suspended US funding to Gavi, which supports global vaccination
🧵

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It’s not that much money considering all the inflation he’s caused

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The fact that Mamdani just seems like a cheerful normal guy who's policies are things like "we're going to tax second homes to fund pothole repairs" or whatever and yet this generates panicked responses like "This is basically Stalin's great purge turned up to eleven" is... telling. It tells things.

4 days ago 16407 3003 225 145
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One of the most reprehensible humans alive

Modeling by Brooke Nichols at Boston University estimates that dismantling USAID led to 762,000 deaths, including >500,000 children

Charles Kenny & Justin Sandefur at the Center for Global Development estimate the number to be between 500,000 & 1 million

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2025 Tesla Cybertruck: Regular Car Reviews
2025 Tesla Cybertruck: Regular Car Reviews YouTube video by Regular Car Reviews

This is an 18 minute and 37 second brutal takedown and non-stop zinger-fest of a video disguised as a car review, and I'm totally here for it. I loved every moment, and nearly spat out my drink more then a couple of times. Enjoy!

5 days ago 176 59 18 11

I agree. Wakefield & his biggest booster—RFK Jr—have unleashed genuine horrors upon the world. I STILL find it hard to wrap my head around the fact that RFK Jr runs America’s health system, with the help of, um, PHYSICIANS like Bhattacharya, Makary, Oz & Høeg 🤯—who took an oath to “first do no harm”

6 days ago 33 4 1 0
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I think this is the most likely explanation for what unfolded after the fact. #DonaldJChrist

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President, Extremely Normal Brain-Wise: Pope Weak on Crime, Also I’m Dr. Jesus Christ

President, Extremely Normal Brain-Wise: Pope Weak on Crime, Also I’m Dr. Jesus Christ

A+ headline.

defector.com/president-ex...

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Opinion
Editorial Board
America’s income tax is progressive
The rich already pay more than their fair share

Opinion Editorial Board America’s income tax is progressive The rich already pay more than their fair share

Unbelievable stuff from the Washington Post on behalf of Jeff Bezos today.

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Fluoride And IQ: An Update We should all be grateful that there's fluoride in our wate

Water fluoridation remains one of the greatest successes of public health - the story of a new study on fluoride and IQ

gidmk.substack.com/p/fluoride-a...

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Is that a Pontiac Aztec?

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This Jay Bhattacharya? www.theguardian.com/us-news/2024...

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Here’s Podcast Jay specifically saying he wouldn’t censor the people he’s censored.

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for folks who may not know about/remember jay bhattacharya's long history of dishonesty and badness, check out the comprehensive documentation in @joho.bsky.social's "we want them infected" and "everyone else is lying to you". valuable reference, esp. for journalists, historians, researchers

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