For nearly a century, we believed the therapeutic effect of ECT is the seizure. Our latest research suggests we may have been looking at the wrong event.
A thread on why cortical spreading depression (CSD) might be the driver of therapeutic benefit.
Work led by @therehugolad.bsky.social

Runtimes by batch size, hidden layer size, and parallel/serial computation

Our new preprint on parallelizing training of temporally precise spiking neural networks is out!

We show up to 44x speedups over a conventional sequential baseline. 1/N

Biology is full of coconuts. 🥥

🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social

We gave a worm brain control of a fly body and it walked

What did we learn? Nothing, other than deep reinforcement learning is effective

We call it the digital sphinx

www.biorxiv.org/content/10.6...

‪Ever wondered how GABAergic interneurons shape cognition? The IN-CODE consortium's latest NeuroView article introduces a "population approach", shifting the focus from individual interneurons to cooperative networks. Dive into the future of interneuron research here: doi.org/10.1016/j.ne...

Representation Biases: Variance Is Not Always a Good Proxy for Importance A central approach in neuroscience is to analyze neural representations as a means to understand a system's function, through the use of methods like principal component analysis, regression, and repr...

Pleased to share that our paper "Representation Biases: Variance is Not Always a Good Proxy for Importance" is now out as Theory/New Concepts paper in eNeuro!
www.eneuro.org/content/13/3... 1/

Come see our Cosyne 2026 posters! Friday: 2-069 (Atena & Manu), 2-096 (Julian), Saturday: 3-091 (Julia)
More info zenkelab.org/2026/03/cosy...

New paper hot off the (pre-)press! We dig into the evolutionary origins of neural computations for behavioral control across mice, monkeys, and humans: www.biorxiv.org/content/10.6....

As our lab's first foray into comparative analysis of neural dynamics, I’m super excited about this work! 1/18

Happy to announce our latest preprint with Friedrich Schuessler and Simone Ciceri: www.biorxiv.org/content/10.6...

A good part of animal behaviour and cognition is innate. Have you ever wondered how the underlying neural circuits develop? We may have a suggestion.

We introduce epiplexity, a new measure of information that provides a foundation for how to select, generate, or transform data for learning systems. We have been working on this for almost 2 years, and I cannot contain my excitement! arxiv.org/abs/2601.03220 1/7

Wanna compare dynamics across neural data, RNNs, or dynamical systems? We got a fast and furious method🏎️
The 1st preprint of my PhD 🥳 fast dynamical similarity analysis (fastDSA):
📜: arxiv.org/abs/2511.22828
💻: github.com/CMC-lab/fast...
I’ll be @cosynemeeting.bsky.social - happy to chat 😉

Congratulations Flavio!

Image of robots struggling with a social dilemma.

1/ Why does RL struggle with social dilemmas? How can we ensure that AI learns to cooperate rather than compete?

Introducing our new framework: MUPI (Embedded Universal Predictive Intelligence) which provides a theoretical basis for new cooperative solutions in RL.

Preprint🧵👇

(Paper link below.)

1/6 New preprint 🚀 How does the cortex learn to represent things and how they move without reconstructing sensory stimuli? We developed a circuit-centric recurrent predictive learning (RPL) model based on JEPAs.
🔗 doi.org/10.1101/2025...
Led by @atenagm.bsky.social @mshalvagal.bsky.social

Excited to see the paper fully published. It's an important milestone for training SNNs with exact gradients, replacing our earlier tricks of a "delay line augmentation" to capture temporal relationships. Delays can now be learnt alongside weights naturally. Amazing work @mbalazs98.bsky.social !

Spiking neural networks people, this message is for you!

The annual SNUFA workshop is now open for abstract submission (deadline Sept 26) and (free) registration. This year's speakers include Elisabetta Chicca, Jason Eshraghian, Tomoki Fukai, Chengcheng Huang, and... you?

snufa.net/2025/

🤖🧠🧪

What makes visual processing in the brain so powerful and flexible? Very excited to share our new work where we started from SOTA models that accurately predict dynamic brain activity during hours of video watching, and investigated core computations underlying visual perception

There might be a bit of misconception here. What the paper very convincingly shows is that visual cortex does not compute global oddball prediction errors and does not receive any top-down predictions that could be used to compute such prediction errors.

A flexible hippocampal population code for experience relative to reward - Nature Neuroscience Sosa et al. find that hippocampal neural activity in mice encodes both environmental location and experience relative to rewards, spanning distances far from reward, through parallel and flexible popu...

It's officially published!! In my main postdoc work with @markplitt.bsky.social and @lgiocomo.bsky.social, we found that the hippocampus simultaneously encodes an animal's spatial position and its experience relative to reward in parallel population codes. 🧵

www.nature.com/articles/s41...

Memory by a thousand rules: Automated discovery of functional multi-type plasticity rules reveals variety & degeneracy at the heart of learning Synaptic plasticity is the basis of learning and memory, but the link between synaptic changes and neural function remains elusive. Here, we used automated search algorithms to obtain thousands of str...

We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...

Dynamic basal ganglia output signals license and suppress forelimb movements - Nature Basal ganglia output neurons fire dynamically in bidirectional and movement-specific patterns to license forelimb movements. 

Forelimb movement control at the basal ganglia - brainstem interface!

Happy to finally share this work from me and @harsh-kanodia.bsky.social with Silvia Arber!

@biozentrum.unibas.ch @fmiscience.bsky.social

www.nature.com/articles/s41...

New #NeuroAI #compneurosky preprint! To better understand how target-directed learning works in the brain, we sought to engineer an artificial neural network capable of solving complex image classification tasks that comprises only experimentally-supported biological building blocks. (1/15)

I've spent much of my PhD thinking about E/I balance, and our latest preprint represents the culmination of that journey. Huge thanks to @fzenke.bsky.social for guiding me.

Looking forward to your thoughts & comments.

Oja's plasticity rule overcomes several challenges of training neural networks under biological constraints Deep neural networks have achieved impressive performance through carefully engineered training strategies. Nonetheless, such methods lack parallels in biological neural circuits, relying heavily on n...

New preprint with my postdoc, Navid Shervani-Tabar, and former postdoc, Marzieh Alireza Mirhoseini.

Oja’s plasticity rule overcomes challenges of training neural networks under biological constraints.

arxiv.org/abs/2408.08408

Top-down feedback is ubiquitous in the brain and computationally distinct, but rarely modeled in deep neural networks. What happens when a DNN has biologically-inspired top-down feedback? 🧠📈

Our new paper explores this: elifesciences.org/reviewed-pre...

How does our brain predict the future? Our review of predictive processing + research program is now on arXiv arxiv.org/abs/2504.09614
50+ neuroscientists distributed across the world worked together to create this unique community project.

Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning” www.nature.com/articles/s41...
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.

1/7: Super excited to share our new paper! This one should be of interest to neuroscientists and deep learning theory folks. This paper was a collaboration with Alexandre Payeur, @averyryoo.bsky.social, Thomas Jiralerspong, @mattperich.bsky.social, Luca Mazzucato, @glajoie.bsky.social

Such wonderful work! Congrats Emerson and @neuronaud.bsky.social 🪅

A prospective code for value in the serotonin system - Nature Merging ideas from reinforcement learning theory with recent insights into the filtering properties of the dorsal raphe nucleus, a unifying perspective is found explaining why serotonin neurons are ac...

I'm excited to share that the last chapter of my PhD thesis is now published in Nature! 🍾

What drives serotonin neurons? We think it's the expectation of future reward and --- critically --- how fast this expectation is increasing. 📈

doi.org/10.1038/s415...

1/6