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Posts by Kerry J. Laing, PhD

This morning my inbox (and ❤️) are full of the flurry of emails saying reviewers have accepted, completed, or declined (also very important for keeping systems moving) manuscript reviews. Thank you for your service to all the steady reviewers out there #Sciencesky

1 month ago 0 0 0 0
A woman holding onto twin babies. She is securing one in her legs while the other is attempting escape!

A woman holding onto twin babies. She is securing one in her legs while the other is attempting escape!

Oldie but goodie popped up in my memories 💕💕. Such a metaphor on my life!! #wrangling

1 month ago 3 0 0 0
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Research Postdoctoral Fellow - Grant & Sengupta Labs in Philadelphia, Pennsylvania, United States of America | Fellows, Students & Interns at Children’s Hospital of Philadelphia Apply for Research Postdoctoral Fellow - Grant & Sengupta Labs job with Children’s Hospital of Philadelphia in Philadelphia, Pennsylvania, United States of America. Fellows, Students & Interns at Chil...

My lab is seeking to co-hire another postdoctoral fellow with the @shaonsengupta.bsky.social team. See details below!

careers.chop.edu/us/en/job/10...

1 month ago 3 3 0 0

😮 where did you spot this beauty?

2 months ago 2 0 1 1
Screenshot of the Miriam-Webster dictionary GIF telling me MY word for 2026 is “enfeebled”. Fabulous, just fabulous! 🤭

Screenshot of the Miriam-Webster dictionary GIF telling me MY word for 2026 is “enfeebled”. Fabulous, just fabulous! 🤭

Oh dear…

3 months ago 0 0 0 0
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Explore the structure and impact of the IDCRC VTEU network in this new CID supplement. Essential reading for clinicians, researchers, and public health experts.

↪️ https://bit.ly/43lUFK4

4 months ago 0 2 0 0

There are 1,700 ballots that need signature confirmation. That is enough to change the election.

Go. Check. Your. Ballot.

komonews.com/news/local/s...

5 months ago 1049 1007 5 45
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Welcome to Seattle!

5 months ago 1 0 1 0
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Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity - Nature Biotechnology T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function.

This is interesting for a number of reasons. www.nature.com/articles/s41...

5 months ago 10 6 1 0
Woman, making a scary jesture, standing in a large open coffin. The coffin is lined with what looks like red velvet.

I shall neither confirm nor deny that this person is me!!

Woman, making a scary jesture, standing in a large open coffin. The coffin is lined with what looks like red velvet. I shall neither confirm nor deny that this person is me!!

Happy Halloween!! 👻 🧛 🎃🦇🧙‍♀️

5 months ago 4 0 0 0
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Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis - Nature An analysis of T cell responses in people with amyotrophic lateral sclerosis shows that the C9orf72 antigen is a key target of autoimmune responses in the disease, and identifies C9orf72 epitopes that are recognized.

Amazing to see data from the Sette group that may help in the fight against ALS; a disease that my mum lost her battle with nearly 4 years ago. 🧪 www.nature.com/articles/s41...

6 months ago 5 2 0 0
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Safety and immunogenicity of investigational herpes simplex virus-2 vaccines in adults with recurrent genital infection HSV529 and G103 are investigational therapeutic vaccines for genital herpes. HSV529 is a replication-defective HSV-2. G103 contains three recombinant …

Our little herpes vaccine study got published. Thanks to coauthors and study sites and volunteers. Also, thanks to the reviewers for appreciating the scientific contributions despite the limitations of a small trial. 🧪💉www.sciencedirect.com/science/article/pii/S026...

6 months ago 10 1 0 0
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Jane Goodall, legendary primatologist, has died at age 91 Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.

JUST IN: Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.

6 months ago 3459 1056 137 284
Intra- and intercellular immune responses across diverse in vitro stimuli and inflammatory disease In vitro stimulation of healthy human immune cells is commonly used to reproduce the immune states observed in disease, both to understand pathology and to test therapeutic approaches. However, experiments typically focus on individual cell types and stimuli and a comprehensive cellular comparison of common immunomodulators and their relevance to disease is lacking. To this end, we performed integrated single-cell transcriptomic profiling of human peripheral blood mononuclear cells treated with 11 different common in vitro stimuli, totalling over 150,000 cells from 21 immune cell subtypes. Comparative analysis of the immunomodulations revealed their shared and unique pathways, for instance stimulation via the T cell receptor (anti-CD3, CytoStimTM) and IFN-α induced broad activation signatures including off-target effects across multiple cell types, whereas TNF-α and LPS elicited more specific responses. Ligand-receptor interaction mapping also uncovered the common and distinct intercellular signalling pathways across stimuli. Comparing the stimuli to patient samples enabled identification of specific inflammatory disease features best replicated by each. For example, IFN-α stimulation recapitulated signatures of SLE across cell types, whereas LPS induced SLE-like changes specifically within monocytes. Comparative cell-cell network analysis showed that in vitro stimuli were able to recreate some, but not all, aspects of intercellular interactions upregulated in SLE, highlighting the limitations of these model systems. This resource provides new insights into the similarities and differences of established immune stimuli at cellular resolution and facilitates appropriate use of in vitro systems to study pathways relevant to disease. ### Competing Interest Statement The authors have declared no competing interest.

🧬 Sharing an exciting new pre-print from the team! We stimulated healthy blood cells with 11 different treatments used in immunology research & created single-cell profiles to compare responses. Hopefully an invaluable resource for immunology/disease researchers 📖 www.biorxiv.org/content/10.1...

9 months ago 30 9 1 0
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Few hours left!!! Cytokines 2025: Submit your abstract for an oral or poster presentation by June 30th! Student and post-doctoral travel grants are still available. Don’t miss out!
seattle.cytokinesociety.org
#Cytokines #Immunology #innate #adaptive #conferences #Seattle

9 months ago 9 2 0 0

A colleague, a friend and a brilliant scientist. The US lost a trusted vaccine expert to an anti-science purge at #ACIP

Americans should be outraged.

10 months ago 64 24 1 1

Except when you are in a zoom meeting. That zoom meeting window seems to be the universal sign for “keep talking to me no matter how many indicators of I can’t talk right now I point out”!

10 months ago 1 0 0 0
Beach rocks stacked to look like two cartoonish people; one big, one small. The rocks used as heads each has a pair of barnacles that make it look like the rocks have eyes. The rock people—not in an AC/DC way, by-the-way—are standing on a rocky beach with a wee bit of dried seaweed in the foreground. 🤘🏼🗿

Beach rocks stacked to look like two cartoonish people; one big, one small. The rocks used as heads each has a pair of barnacles that make it look like the rocks have eyes. The rock people—not in an AC/DC way, by-the-way—are standing on a rocky beach with a wee bit of dried seaweed in the foreground. 🤘🏼🗿

Just a couple of rock heads hanging out at the beach #beachart

10 months ago 5 0 0 0
Information from the National Weather Service- Seattle. Severe Thunderstorm Outlook valid for Wednesday, March 26, 2025.
Hazard Risks
Up to 15-29% chance of severe hail (greater than 1" in diameter) for the Bellevue/Seattle area
5-14% chance of severe wind gusts (greater than 58 mph)
2-4% chance of a tornado

What should you do?
Monitor the latest forecasts
Follow a trusted weather source and check back frequently
Have a plan in case a warning issued for your area

Information from the National Weather Service- Seattle. Severe Thunderstorm Outlook valid for Wednesday, March 26, 2025. Hazard Risks Up to 15-29% chance of severe hail (greater than 1" in diameter) for the Bellevue/Seattle area 5-14% chance of severe wind gusts (greater than 58 mph) 2-4% chance of a tornado What should you do? Monitor the latest forecasts Follow a trusted weather source and check back frequently Have a plan in case a warning issued for your area

NWS Seattle is noting an unusual risk of severe thunderstorms today, primarily in the late afternoon through the evening. The primary hazards are:
⛈️ Hail in excess of 1" diameter
🍃 Wind gusts in excess of 58mph
🌪️ Possible isolated tornado

1 year ago 4 2 0 1

Well said Tad Williams, well said: “A man who will not listen carefully to advice honestly given is a fool. Of course, a man who blindly takes any advice he receives is a bigger fool.” #reading

1 year ago 0 0 0 0
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Killing PEPFAR means killing millions of people All to save 0.08 percent of the budget.

They’re killing off PEPFAR, one of the most successful global health programs *ever*, which prevents HIV & keeps those living with HIV healthy & non-infectious. Killing PEPFAR means a lot more HIV-related death & many more new infections globally.

1 year ago 33 7 1 0
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How sad and incredibly shocking. I remember Fiona well. Gone far too soon.

1 year ago 1 0 0 0
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Seattle scientists fight back against Trump cuts, disinformation “No one is coming to save us from this,” said Abraham Flaxman, a professor at the University of Washington. “We’re going to have to save ourselves.”

www.seattletimes.com/seattle-news...

#standupforscience

Many, many thanks to all who attended, the speakers, and to the incredible @sufsseattle.bsky.social organizers!!!

1 year ago 29 12 0 0

I post this, not just because my career and livelihood are on the line with the illegal cuts and chaos of the current administration and DOGE, but because the cessation of science will impact the nation as a whole. (2)

1 year ago 0 0 0 0

Great article that highlights the Stand up for Science rally that many of us supported yesterday, and our colleague Chetan spoke at. The cuts to science impact us all. (1)

1 year ago 0 0 1 0
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Over 100 people have gathered for the Stand Up for Science rally outside of the Mural Amphitheater at the Seattle Center. The rally is scheduled to begin at 12 p.m..

Updates on the event will be provided on this thread.

Photo via @emorudphoto.bsky.social

1 year ago 49 7 17 2
Bob Ferguson at a Stand Up for Science podium

Bob Ferguson at a Stand Up for Science podium

Washington governor Bob Ferguson speaking at the Seattle Stand Up for Science rally. Just bragged about his 58-3 record of suing the last Trump admin as AG and promising to keep it going #standupforscience

1 year ago 49 6 1 0

Ah yes. Free EMBOSS tools in there a fabulous.

1 year ago 1 0 0 0
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Comment: Pending cuts to medical research would harm all in state | HeraldNet.com As UW medical scientists, we urge Washingtonians to defend the NIH’s life-saving research funding.

Patrick Mitchell (@psmitchej.bsky.social), Thornton Thompson and I wrote an OpEd, with support from 650+ biomedical researchers across Washington State (450+ at time of submission).

www.heraldnet.com/opinion/comm...

List: www.moltkelab.com/s/NIH-OpEd-S...

1 year ago 37 18 0 2
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NIH indirects case update:

Hearing ongoing now, and I'll try to live tweet some notable exchanges.

Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:

(I'm paraphrasing here)

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