Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation - Nature Immunology Prinz and colleagues examine the distinct functions and repopulation properties of leptomeningeal and perivascular macrophages that mediate immune responses at brain boundaries.

Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation

Thanks for the show!

Thanks again Laz for the entertainment

The greatest sporting event of the year is back.

The conch was blown at 5:00am. The 2026 Barkley Marathons begins in one hour. #BM100

WE ARE HIRING!

The Smyth Lab at Monash University is looking for a postdoc to join our team!

Come join us if you are excited about neuroimmunology and the meninges.

📍 Melbourne, Australia 🇦🇺

Apply now: careers.pageuppeople.com/513/cw/en/jo...

#Neuroimmunology #Meninges #PostdocJobs

Niche-specific dermal macrophage loss promotes skin capillary ageing - Nature Capillary-associated macrophages are selectively lost over time, contributing to impaired vascular repair and reduced tissue perfusion in older mice.

Niche-specific dermal macrophage loss promotes skin capillary ageing

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting - Nature Neuroscience The authors describe a mechanism for the clearance of macromolecules from cerebrospinal fluid in which macromolecules traverse from periarterial to perivenous spaces, at sites where intersecting lepto...

www.nature.com/articles/s41...

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting

The 2025 Barkley Marathons is over. There are no finishers. #BM100

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease

www.nature.com/articles/s41...

Frontiers | Immune conversations at the border: meningeal immunity in health and disease

Immune conversations at the border: meningeal immunity in health and disease

www.frontiersin.org/journals/imm...

Immune control of brain physiology - Nature Reviews Immunology The peripheral immune system communicates with the brain through diverse anatomical routes to shape brain physiology. Here we discuss why such diversity is needed and explore how these routes are leve...

Immune control of brain physiology

www.nature.com/articles/s41...

The immunology of stroke and dementia Ischemic stroke and vascular cognitive impairment are global health threats. Recent research has uncovered a previously underappreciated dynamic interplay between brain-resident, meningeal, and system...

The immunology of stroke and dementia: Immunity www.cell.com/immunity/ful...

« L’expérimentation animale n’est pas toujours nécessaire mais demeure indispensable » TRIBUNE. Dans une tribune au « Monde », un collectif de 2 829 chercheurs et universitaires, dont huit présidents d’université, dénonce les contrevérités avancées par des parlementaires pour taxer les ...

« L’expérimentation animale n’est pas toujours nécessaire mais demeure indispensable »

www.lemonde.fr/sciences/art...

Every day a new role for macrophages 🤩

La recherche biomédicale française mérite mieux qu’une nouvelle taxe.

Aujourd’hui, elle a besoin de votre soutien pour se faire entendre :

forms.office.com/pages/respon...

Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...

Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge

www.nature.com/articles/s41...

Vous parlez français🇫🇷? Vous avez entre 18 et 85 ans ? Vous avez un ordinateur portable💻?
Alors vous pourrez nous aider à faire avancer la recherche sur la perception du temps⏰en faisant ce bref questionnaire en ligne🌐
Pour participer👉🏻 bit.ly/3CunJEA
Merci !

🧠 barriers & neurovasculature starter pack - please reply here if you are not on it yet & would like to be added 😊 go.bsky.app/RB6RXKy

CAMs in command: aging brain macrophages fine-tune stroke immune responses Central nervous system-associated macrophages (CAMs) are a unique subset of immune cells located at the interface between the blood and the brain parenchyma. In a recent study in mice, Levard and coll...

Check out the @TrendsNeuro Spotlight on our recent paper uncovering the role of CNS-associated macrophages in ischemic stroke. Huge thanks to the Louise McCullough group for highlighting our work!

www.cell.com/trends/neuro...

Central nervous system-associated macrophages modulate the immune response following stroke in aged mice - Nature Neuroscience How aging influences peripheral immune cell infiltration and the role of these cells following traumatic injury of the CNS is unclear. Here, the authors show that aging transforms CNS-associated macro...

Very happy to share our paper published in @NatureNeuro, investigating the role of CNS border-associated macrophages in stroke-induced neuroinflammation during aging! 🤩

www.nature.com/articles/s41...

@BbCaen @Inserm @Universite_Caen @Cyceron14 @InsermNordOuest

Thanks for this! Can i be added?

L'intégrale relancé ici 🙋🏻

Encore mieux quand une bouteille est vide et que le bidule clignote en rouge 😁