I’m a Nobel Prize-winning immigrant. I can no longer recognize this country. Attacks on science and immigrants are destroying America.

Nobel Laureate Jack Szostak “This country has given me endless opportunities…: The America we inhabit today bears almost no resemblance to the country I chose all those years ago” newsletter.ofthebrave.org/p/im-a-nobel...

Congratulations! Will read.

All my best ideas have already been published!

Watching SNL I think @peterhotezmdphd.bsky.social could be Jack Black!

a baby is crying in a crowd of people while a woman holds it . ALT: a baby is crying in a crowd of people while a woman holds it .

Some totally awesome updates from grant-witness.us

All of my funding curves and more in an easily useful form!

grant-witness.us/funding_curv...

🧵

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Prominent Climate Scientist Resigns From NASA, Citing Trump’s Attack on Science

Not so marvelous news.

~95,000 scientists have left the federal government since the Trump regime took over.

“I think it’s a real mistake to forget where the pipeline for all this begins.”

John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it.
www.crick.ac.uk/news/2026-03...

You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database.

This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list.

www.ebi.ac.uk/about/news/t...

A complete set of canonical nucleobases in the carbonaceous asteroid (162173) Ryugu - Nature Astronomy Samples returned from the asteroid Ryugu contain all five canonical nucleobases (A, G, C, T and U). Their presence in Ryugu and Bennu supports the hypothesis that carbonaceous asteroids contributed to the prebiotic chemical inventory of early Earth.

Samples returned from the asteroid Ryugu contain all five canonical nucleobases (A, G, C, T, U). Their presence in Ryugu and Bennu supports the hypothesis that carbonaceous asteroids contributed to the prebiotic chemical inventory of early Earth. http://dlvr.it/TRWtVp ☄️

New OpenFold3 preview out! (OF3p2)

It closes the gap to AlphaFold3 for most modalities.

Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

White House stalls release of approved US science budgets The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers.

The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

New TrakLab Picture for 2026. Great eager young scientists poised for discoveries this year.

The most important #RNA conference of the year with lots of amazing science and a really friendly atmosphere. This year in beautiful Montreal 🇨🇦 !

www2.rnasociety.org

Amazing

📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open)

🗓 May 30–31, 2026

✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.

Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...

This line graph illustrates the percentage change in agency staff levels from the previous year for nine major U.S. federal scientific and health organizations between the fiscal years 2016 and 2025. The agencies tracked include the CDC, Department of Energy, EPA, FDA, NASA, NIH, NIST, NOAA, and NSF. For the majority of the timeline between 2016 and 2023, the agencies show relatively stable fluctuations, generally staying within a range of +5% to -5% change per year. However, there is a dramatic and uniform plummet starting in the 2024–25 period. Every agency depicted shows a sharp downward trajectory, with staffing losses ranging from approximately -15% to over -25%. The Environmental Protection Agency (EPA) shows the most significant decline, dropping to roughly -26%, while the National Institute of Standards and Technology (NIST) shows the least severe but still substantial drop at approximately -15%.

This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.

www.nature.com/immersive/d4...

We are excited to host the first WOW Symposium for the 'Mutagenesis and Mechanistic Assessment" Special Interest Group @emgsus.bsky.social. Hosting Drs. Graham Walker (MIT), Mikhael Kashlev (NCI), and Julian Sale (MRC).

Please join us on March 6th at 11 am. Register at emgs-us.org/event/MolMec...

Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?

I made an app you might like: adamkucharski.github.io/pdf2plot/

It all started a few years ago... 🧵

Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social

Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...

Watched Stranger Things S5E5 tonight with the fam. They was a pretty good representation of the DNA replication fork in Henry’s journal. No one else was impressed but me. 🧬

Live thread of the NSF biology virtual office hour:

🧵

Horrifying news being confirmed about the state of NSF at the NSF IOS/BIO webinar

I’ve earned my PhD — what now? A chemist faces a classic early-career dilemma: what should they do next, and how do they start?

Grads.. Start building your network now. It is so essential for life after graduation. www.nature.com/articles/d41...

All the centers they’re cutting add up to less than $7 million in spending.

UNC athletics budget is $185.4 million for the 2025-26 fiscal year.

Adam Luthman says: it depends. Some answers here: rdcu.be/eUVBj

Chocolates! Mint flavored. 😘

Make sure to gift something to you administrative staff that keeps the Department running all year long. For me, the best gift to give is Frangos! Originally from Chicago!

I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...

I prefer Arial

Sugars, ‘Gum,’ Stardust Found in NASA's Asteroid Bennu Samples - NASA The asteroid Bennu continues to provide new clues to scientists’ biggest questions about the formation of the early solar system and the origins of life. As

Everyone shut thefuck up in that they discovered ribose and, for the first time in any extraterrestrialsample, glucose on Bennu.

This adds to earlier this yr 14 of the 20 amino acids thatlife on Earth uses to make proteinsand all five nucleobases that lifeon Earth uses

www.nasa.gov/missions/osi...