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Posts by Yue Kris Wu

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Planning in the Brain: It's Not What You Think It Is The neuroscience of planning has long been analogized to search algorithms in artificial intelligence (AI), which simulate future actions to guide immediate choices. We argue that advances in both neu...

New Annual Review with @nathanieldaw.bsky.social: “Planning in the Brain: It's Not What You Think It Is.” We argue that the brain's 'planning' machinery is mostly used for learning from simulated experience, and that thinking prospectively at decision time is just one special case of this process.

11 hours ago 90 36 3 2
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Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

@hhmi-science.bsky.social's
#FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits

Stable, sustained support can transform your career:

Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA

5 days ago 94 63 5 1
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⏳ Two weeks left to send us your Satellite Workshop proposals for the #BernsteinConference 2026!

🗓️ Deadline: April 29, 15:00 CEST

More info 👉 bit.ly/40HybkI

#BernsteinNetwork #CompNeuro

6 days ago 6 3 0 0

I’m excited to share that I’ll be starting my computational neurosci & machine learning lab at UCLA this July! ☀️


We’ll be working on computational methods for high-throughput neural data analysis, optical interrogation of neural circuits, & mechanistic models of artificial+bio neural systems. ⤵️

2 weeks ago 48 8 3 7
Entorhinal cortex represents task-relevant remote locations independently of CA1 - Nature Neuroscience Neurons in medial entorhinal cortex collectively represent discrete nonlocal positions during immobility. During this nonlocal coding, CA1 is uncoupled from entorhinal cortex. These representations ar...

My main postdoc work is now published: www.nature.com/articles/s41...! We (myself, Isabel Low, Frances Cho, and @lgiocomo.bsky.social) discovered task-relevant remote representations in entorhinal cortex independent of CA1. #paperthread below! 1/13

2 weeks ago 69 27 6 1
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Today, we’re thrilled to report “A right-hemispheric language network at single-neuron resolution”, the first systematic investigation into the #single #neuron correlates of #language functions in the #right #hemisphere of the #human #brain. #neuroskyence 🧪
www.biorxiv.org/content/10.6...

3 weeks ago 40 12 1 0

My lab at U Göttingen is looking for a PostDoc or PhD student to work on an ERC-funded project at the intersection of computer vision, graphics & neuroscience.

4 weeks ago 9 7 1 0
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It is wonderful to be back in Europe to attend #Cosyne2026, reconnecting with old friends and learning about a lot of exciting work, especially the work by Jeff Magee. Stay curious and see you all next time.

1 month ago 8 0 0 0
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GitHub - iinnpp/isttc: iSTTC: intrinsic neural timescales estimation iSTTC: intrinsic neural timescales estimation. Contribute to iinnpp/isttc development by creating an account on GitHub.

New paper out in PLOS Computational Biology!

We introduce iSTTC, a robust method to estimate intrinsic neural timescales from single-unit recordings.

Congrats to Irina Pochinok for leading the project!

Package: github.com/iinnpp/isttc

Paper: journals.plos.org/ploscompbiol...

1 month ago 32 8 2 1
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To accommodate applicants and PIs attending Cosyne, we’ve extended the MCN application deadline to Sunday, Mar 22.

Please repost.

1 month ago 10 15 0 0

Excited to be in Lisbon for my first #cosyne26 and to present TONIGHT on my work on developmental changes to spectral tuning and vocalization processing (and their interactions) in the postnatal auditory cortex! Poster 1-167, come to learn more or just to see me fight through the jet lag!

1 month ago 5 1 0 0
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Deconstruction of a memory engram reveals distinct ensembles recruited at learning - Nature Neuroscience Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.

How does the brain build a memory?
A common assumption is that the neurons activated during an experience collectively form the memory engram.
In our new Nature Neuroscience paper (finally out!), we show that this is not the case.
www.nature.com/articles/s41...

1 month ago 165 61 11 1
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The deadline for applying to the Methods in Computational Neuroscience summer course at MBL in Woods Hole is approaching (March 16)! An exciting course with an amazing lineup of lecturers in a beautiful location www.mbl.edu/education/ad...

1 month ago 26 10 0 1
Characteristics and dynamical signatures of recurrent cortical circuits during context-dependent processing Context profoundly shapes neural responses and behavior. During context-dependent sensory processing, recurrent connections shape the integration of feedforward sensory input and feed-back input from downstream brain regions. How do different cell types, interacting through spatially structured recurrent lateral connections, give rise to context-dependent processing and circuit stability, and what dynamical signatures reveal their individual roles? To answer these questions, we employ data-driven approaches to construct spatially extended stabilized supralinear network models that capture the responses of diverse cell types in the mouse primary visual cortex during context-dependent processing. Analysis of well-fitting models reveals that the dominant inhibitory cell type affecting excitatory neurons is not fixed but dynamically varies with stimulus and space. While PV-mediated stabilization is indispensable across all models and stimulus conditions, SST-mediated stabilization is also required, and likely in a stimulus-dependent manner. Interestingly, even when a specific inhibitory cell type is required for circuit stabilization, a uniform perturbation of it does not necessarily produce a paradoxical change in its mean activity. Instead, assessing cell-type-specific circuit stabilization requires patterned perturbations, where paradoxical effects manifest along specific activity modes. Finally, we show that recurrent connections and input-output nonlinearities are essential for integrating feedforward and feedback inputs to reproduce the observed spatial response profiles. Recurrent excitatory connections, in particular, are required to account for responses to small stimuli, where external inputs are relatively weak. Taken together, our work reveals the crucial role of ubiquitous biological components in context-dependent processing and delineates the characteristics and dynamical signatures of these circuits. ### Competing Interest Statement The authors have declared no competing interest. Gatsby Charitable Foundation, GAT3708 National Institutes of Health, https://ror.org/01cwqze88, 1RF1DA056397, U19NS107613, T32 EY013933 U.S. National Science Foundation, DGE-2036197 Simons Foundation, SCGB 543017 Agencia Estatal de Investigación, PID2023-149174NB-I00

Interested in cell type diversity, the cortical operating regime, and how recurrent connections shape the integration of feedforward and feedback inputs during context-dependent processing? Come check out my poster [1-038] at #Cosyne2026.

Link: doi.org/10.64898/2026.02.06.704473

1 month ago 13 2 0 0

Happy to announce our latest preprint with Friedrich Schuessler and Simone Ciceri: www.biorxiv.org/content/10.6...

A good part of animal behaviour and cognition is innate. Have you ever wondered how the underlying neural circuits develop? We may have a suggestion.

2 months ago 11 4 1 0

I will present a poster on this work at Cosyne and would be very happy to discuss it further with anyone interested.

2 months ago 2 0 0 0
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🚨 preprint alert!

Check out our revised manuscript out on bioRxiv, where we strengthen the link between D1-dependent dopamine signaling in the anterior insular cortex and the control of anxiety.

@anna-beyeler.bsky.social

www.biorxiv.org/content/10.1...

2 months ago 9 3 2 0
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Mathematical Methods in Computational Neuroscience Summer school in Eresfjord, Norway (July 8th - 26th, 2024)

Applications are now open for the summer school: 𝐌𝐚𝐭𝐡𝐞𝐦𝐚𝐭𝐢𝐜𝐚𝐥 𝐌𝐞𝐭𝐡𝐨𝐝𝐬 𝐢𝐧 𝐂𝐨𝐦𝐩𝐮𝐭𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞

🧠 Apply before March 15: www.compneuronrsn.org

📍 Located in beautiful Eresfjord 🇳🇴
🗓️ Between July 6-24

Supported by the @kavlifoundation.org
In collaboration with @kavlintnu.bsky.social

2 months ago 62 29 0 5

Finally, we highlight the importance of ubiquitous biological features, such as recurrent connections and input-output nonlinearities, in shaping the integration of feedforward and feedback inputs during context-dependent processing. (11/11)

2 months ago 0 0 0 0
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We show that assessing cell-type-specific circuit stabilization requires patterned perturbations, where paradoxical effects manifest along specific activity modes. We further characterize the spatial structure of the required patterned perturbations. (10/11)

2 months ago 0 0 1 0
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As shown below, although SST is required for stabilization across the top optimized models under this stimulus condition, a uniform excitatory perturbation of SST does not always paradoxically decrease in its mean activity; in several models, the mean activity instead increases. (9/11)

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Interestingly, we find that in high-dimensional spatially extended models, even when a specific inhibitory cell type is required for circuit stabilization, a uniform perturbation of it does not necessarily produce a paradoxical change in its mean activity. (8/11)

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Most previous computational studies have focused on either population models or networks lacking explicit spatial structure. Perturbations used to probe paradoxical effects are typically applied uniformly to all inhibitory neurons, every inhibitory neuron receives the same perturbative input. (7/11)

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As shown in Tsodyks et al. (1997), Sanzeni et al. (2020), and Sadeh & Clopath (2021), inhibition stabilization is commonly associated with paradoxical effects, whereby inhibitory activity paradoxically decreases in response to excitatory current injection into the inhibitory population. (6/11)

2 months ago 0 0 1 0
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More specifically, while PV-mediated stabilization is indispensable across all models and stimulus conditions, SST-mediated stabilization is also required, and likely in a stimulus-dependent manner. (5/11)

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This context-dependent shift in the dominance of cell-type-specific inhibition is accompanied by a corresponding change in cell-type-specific inhibition stabilization, that is, a change in the requirement of a particular inhibitory cell type for stabilization. (4/11)

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Analysis of well-fitting models reveals that the dominant inhibitory cell type affecting excitatory neurons is not fixed but dynamically varies with stimulus and space. (3/11)

2 months ago 0 0 1 0
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To answer these questions, we use data-driven approaches to construct spatially extended circuit models that capture the responses of diverse cell types in the mouse primary visual cortex during context-dependent processing. (2/11)

2 months ago 0 0 1 0

Excited to share our new work from @kenmiller.bsky.social lab!

How do different cell types, interacting via recurrent connections, give rise to context-dependent processing and circuit stability, and what dynamical signatures reveal their individual roles? (1/11)

doi.org/10.64898/2026.02.06.704473

2 months ago 11 3 1 1
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Our paper is out in @natneuro.nature.com!

www.nature.com/articles/s41...

We develop a geometric theory of how neural populations support generalization across many tasks.

@zuckermanbrain.bsky.social
@flatironinstitute.org
@kempnerinstitute.bsky.social

1/14

2 months ago 278 101 7 1