Our latest comment is now out!

We discuss how the infection environment can shape #AntimicrobialResistance phenotypes, an important but often overlooked factor for predicting antimicrobial efficacy against bacterial pathogens 🦠🧫

#MicroSky
@rug-lrs.bsky.social

Mucha suerte en la nueva etapa!!

How does treatment induced antibiotic resistance happen in real-world infections? We analysed 25k Pseudomonas isolates from 180 patients in a clinical trial to find out! TLDR: The ecological and evolutionary paths are surprisingly diverse & complex even in patients receiving identical treatment…

🧵 New preprint! Our 4-lab team evolved Streptococcus pneumoniae in antibiotic-treated mice of varying immune states and discovered something surprising: bacteria rarely evolved resistance. Instead, they found a different way to survive — by rewiring RNA turnover.
🔗 www.biorxiv.org/content/10.6...

Plasmid mutation rates scale with copy number | PNAS Plasmids are extrachromosomal DNA molecules that spread by horizontal transfer and shape bacterial evolution. Plasmids are typically present at mul...

New paper out in PNAS!!! 🎉

Do more plasmid copies mean faster evolution?

🧵 Dive into the story

www.pnas.org/doi/10.1073/...

Pyocyanin produced by Pseudomonas aeruginosa Creates Legacy Effects That Boost Antibiotic Resistance Evolution in Enterococci Polymicrobial infections are small communities of multiple interacting bacterial species. Interactions among constituent species may modify the growth of community members in the presence of antibioti...

New preprint:
www.biorxiv.org/content/10.6...

Immune protection and disease tolerance in Pseudomonas aeruginosa infections by pyruvate cross-feeding Chronic infections by Pseudomonas aeruginosa in people with cystic fibrosis are characterized by persistent inflammation and oxidative stress, yet the mechanisms enabling bacterial persistence are not...

New preprint!👇
Pyruvate secreted by P. aeruginosa acts as a signaling molecule during infection, reducing oxidative stress, dampening immune activation and promoting persistence
Bacterial metabolism isn’t just a background process but an active player in infection🦠🧫
www.biorxiv.org/content/10.6...

The @imili-micro.bsky.social project is such a beautiful and necessary initiative!

I am really glad we could contribute.

Special kudos to PhD student Lilibeth Torres who did the #Klebsiella drawing and wrote the text

- @cbitoulouse.bsky.social

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-10:

@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social

the ESKAPE Rogues

grupos.eez.csic.es/imili/wp-con...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-11:

@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social

the ESKAPE Rogues

grupos.eez.csic.es/imili/wp-con...

The NoticiaSEM: an excellent monthly newsletter for Spanish-speaking microbiologists, now celebrating its 200th edition. It also publishes Portraits from the IMiLI. On the occasion of its 200th "birthday", it published an IMiLI "MicroChat" on......birthdays.

www.semicrobiologia.org/revista-noti...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-5
@pablolaborda.bsky.social

How we can fight AMR

imili.org/new_gallerie...

@sbigot.bsky.social

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-6
@pablolaborda.bsky.social, @crisherencias.bsky.social

How we can fight AMR

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-7
@pablolaborda.bsky.social
@crisherencias.bsky.social

How we can fight AMR

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-8
@pablolaborda.bsky.social
@crisherencias.bsky.social

How it works

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-9
@pablolaborda.bsky.social
@crisherencias.bsky.social

How it works

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-4
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-3
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-2
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-1
@pablolaborda.bsky.social
imili.org/pdf/Antimicr...

New preprint out! 📣🚨

We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠

#Microsky

We just opened the Bluesky account of the International Microbiology Literacy Initiative (IMiLI) headed by Ken Timmis. Follow us to know more about the initiative or even better become one of our volunteers to bring Microbiology to kids all ages around the world 🦠 🏫

Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org

Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...

This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...

New paper out! 🔈🔈📣📣

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.

Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻

www.biorxiv.org/content/10.1...

Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬?

In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!

👇 Check out all the details in Paula’s thread!

Hint: 🐇 (most of the time)

Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria - Nature Communications The authors investigate the distribution of the aminoglycoside resistance gene npmA in Gram-positive bacteria via a mobile genetic element, highlighting its global presence and cross-species transfer ...

Our paper “Global dissemination of npmA mediated pan‑aminoglycoside resistance via a mobile element in Gram‑positive bacteria” is now in @natcomms.nature.com. Part of my freshly defended PhD, so doubly happy! 😄🎉

🧵 (1/14)

www.doi.org/10.1038/s414...

Universal rules govern plasmid copy number - Nature Communications Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...

🚨🚨New paper out in @natcomms.nature.com!!

Come for the first large-scale analysis of plasmid copy number across species,
stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬

👉 www.nature.com/articles/s41...

Enhorabuena Alberto!! 💪

Una nueva investigación identifica un mecanismo molecular que interviene en la pérdida de la resistencia bacteriana al antibiótico ciprofloxacino.

📰Lee aquí más información: bit.ly/4mMl2AN
DOI: bit.ly/43uUtbT