Patterns of Structural Disconnection Driving Proprioceptive Deficits After Stroke Background: Stroke is a leading cause of death and disability worldwide, with proprioceptive impairments affecting up to 64% of survivors. These impairments hinder sensorimotor function and motor reco...

What breaks proprioception after a stroke? Not just lesions, it’s the disconnectome. A new study maps how white matter network disconnections drive proprioceptive deficits.

www.biorxiv.org/content/10.1...

Lawful kinematics link eye movements to the limits of high-speed perception - Nature Communications Saccadic eye movements sample the visual world, but the retinal motion they entail goes unnoticed. This study shows that lawful saccade kinematics predict motion visibility, omitting saccade-like moti...

This study finds that the visual system is tuned to the specific speed and duration of saccades, so much so that it filters out anything that looks like them.
A law of vision grounded in action.

www.nature.com/articles/s41...

Impressive work, but representational alignment is tricky. Sometimes preserving global geometry is ideal, other times, distinctions matter more.

Philosophically, computational theories demand a more precise notion of representation than alignment alone.
arxiv.org/pdf/2505.12540

Incredible dataset and elegant analysis! Would love to see efforts toward making parts of this dataset openly accessible.
Even anonymized versions of this data could be a goldmine for perception research.

ai.meta.com/research/pub...

Just had the pleasure of joining a panel on academia vs. industry hosted by the neuroscience department at Ben-Gurion University.

Grateful for the invitation and the thoughtful discussion about navigating career paths, and building things that matter.

The impact of localization and registration accuracy on estimates of deep brain stimulation electrode position in stereotactic space Abstract. Effects of deep brain stimulation (DBS) depend on millimetric accuracy and are commonly studied across populations by registering patient scans to a stereotactic space. Multiple factors cont...

This new study shows ~0.6mm of error can stem from consistent misalignment in MNI space, detectable using anatomical fiducials (AFIDs).

direct.mit.edu/imag/article...

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This could be the opening of a richer diagnostic pipeline where blood guides classification and neurotech guides personalization. What do you think? 🧠

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We know people with high amyloid but no symptoms, and others with fast decline and “normal” scans.
That mismatch is where multimodal neurotech shines: tracking cognition, affect, attention, and more.

FDA Clears First Blood Test Used in Diagnosing Alzheimer’s Disease The U.S. Food and Drug Administration cleared for marketing the first in vitro diagnostic device that tests blood, to aid in diagnosing Alzheimer’s disease.

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The FDA’s clearance of an Alzheimer’s blood test is huge, but it doesn’t mean other tools are obsolete.
If anything, it reveals how much we still need to understand about how pathology meets behavior.

www.fda.gov/news-events/...

Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

A new study shows lipoamide dissolves stress granules in ALS via redox modulation of the methionine-rich SFPQ.

www.nature.com/articles/s41...

Individual Differences in Cognition and Perception Predict Neural Processing of Speech in Noise for Audiometrically Normal Listeners Individuals with normal hearing exhibit considerable variability in their capacity to understand speech in noisy environments. Previous research suggests the cause of this variance may be due to indiv...

Neural markers (like N1 amplitude differences) say more about your listening-in-noise ability than behavior does.

Should hearing diagnostics move beyond the audiogram and include cognitive tests or EEG-based attention measures?

www.eneuro.org/content/12/4...

Can memories become precise without excitatory scaling? A beautiful model of how top-down inputs and interneuron diversity orchestrate memory refinement.

Capturing the emergent dynamical structure in biophysical neural models Complex neural systems can display structured emergent dynamics. Capturing this structure remains a significant scientific challenge. Using information theory, we apply Dynamical Independence (DI) to ...

This paper proposes “Dynamical Independence” as a way to capture when macro-level neural dynamics become their own thing, no longer reducible to the microscale. Really exciting work!
doi.org/10.1371/journal.pcbi.1012572

A neural mechanism for learning from delayed postingestive feedback - Nature Illness signals from the gut reactivate and strengthen flavour representations in the amygdala to support learning from delayed postingestive feedback.

A beautiful work on how the amygdala bridges the time gap between taste and delayed gut feedback using neural reactivation.

Turns out, CGRP neurons trigger a replay of flavour codes in the amygdala. Taste, then tummy ache = memory
www.nature.com/articles/s41...

Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations Bardon et al. show that different anesthetic drugs have similar effects on the phase alignment of neural oscillations across cortical areas. Neighboring regions within a hemisphere become misaligned, ...

Fascinating work shows how ketamine and dexmedetomidine converge on large-scale phase realignment. Love the idea of interhemispheric hyper-synchrony as a potential unconsciousness signature.
www.cell.com/cell-reports...

Differential effects of illness and antipsychotics on cortical thinning in first episode psychosis Introduction: Cortical grey matter loss is a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and has been shown to progress with ongoing illness. A major unresolved...

People with psychosis receiving placebo show cortical thinning over 1st year of illness, but those receiving antipsychotics do not.

Could serotonergic modulation be the secret sauce behind the protective effect? PET-guided dosing next? 🧐
www.medrxiv.org/content/10.1...

Insight predicts subsequent memory via cortical representational change and hippocampal activity - Nature Communications Insight, involving representational change, can boost long-term memory. Here, in an fMRI study, the authors show that insight triggers stronger conceptual shifts in solution relevant brain regions and...

An image goes from nonsense to “Oh, it’s a dog!” and suddenly VOTC flips its code, hippocampus fires, and the moment embeds itself in memory.

Turns out the best way to remember something might be to feel like you’ve just discovered it 👀

www.nature.com/articles/s41...

Humans learn generalizable representations through efficient coding - Nature Communications Reinforcement learning models of human behavior are limited in explaining the capacity for generalization. Here, the authors propose an efficient coding principle for reinforcement learning, whereby a...

Rodent vision seems to rely on a shared, low-D manifold that all areas sample differently. If true, model “layering” might be a bad metaphor? 👀

www.nature.com/articles/s41...

Functional connectomics spanning multiple areas of mouse visual cortex - Nature Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neuron...

MICrONS released a mouse visual cortex with dense EM + calcium imaging.

75K neurons, 0.5B synapses, open access.

If your model of V1 still uses toy stimuli and artificial connectivity, MICrONS just raised the bar 👀

www.nature.com/articles/s41...

A first-principles mathematical model integrates the disparate timescales of human learning - npj Complexity npj Complexity - A first-principles mathematical model integrates the disparate timescales of human learning

This might be the cleanest computational model of learning I’ve seen.

skill plateaus seems to emerge from dynamic micro-decisions to work or rest.
Feels like a step toward better modeling.

www.nature.com/articles/s44...

Impaired motor-to-sensory transformation mediates auditory hallucinations Can the absence of inhibition lead to auditory hallucinations? This study shows that the impairment of motor-based sensory predictions causes erroneous monitoring of imprecise internal auditory repres...

What if hearing voices isn’t about extra activity, but broken calibration?
Schizophrenia patients with AVHs have both no suppression and a wrong enhancement.
Motor signals go rogue, and the brain listens.

journals.plos.org/plosbiology/...

Turns out epithelial cells can spike, slowly.
Injury triggers propagating voltage waves across cell layers, relying on mechanosensitive ion channels.

How does this impact how we think about wound healing, morphogenesis, and body-wide communication? 👀

www.pnas.org/doi/10.1073/...

Hello Bluesky! I am an engineer/scientist currently working at the MRC LMB in Cambridge UK. During my PhD I developed new imaging technologies to shed light on the dynamics of living cells e.g. here is a movie of 6 organelles in live human cancer cells. Follow for more updates! #science #biology

A 🦋-inspired neural tube for #FluorescenceFriday! Imaged by @siewzhuan.bsky.social #DevBio 🧪👩‍🔬

Happy #FluorescenceFriday ! Let's celebrate with a colorful snapshot of the developing ventral spinal cord of a 🐣 embryo. #neuroscience #microscopy

Happy #FluorescenceFriday !
Let's celebrate with a colorful image of a developing ventral spinal cord of a 🐣 embryo.
#neuroscience #microscopy

Hey! Just giving this platform a shot 👀