A bifunctional snoRNA with separable activities in guiding rRNA 2’-O-methylation and scaffolding gametogenesis effectors - Nature Communications Small nucleolar RNAs (snoRNAs) are known for their role in RNA modification to regulate gene expression. Here, the authors identify a snoRNA that not only guides ribosomal RNA 2’- O-methylation but al...

Happy to see this collaborative study out! A multitasking snoRNA at play in ribosome biogenesis and gametogenesis in fission yeast - project led by Mathieu Rougemaille @i2bcparissaclay.bsky.social and supported by a joint funding from @agencerecherche.bsky.social 🙏 - www.nature.com/articles/s41...

R-loops and Genetic Instability: a Chicken and Egg Problem Investigating the relationships between R-loops and genetic instability led to the discovery that some DNA:RNA hybrids actually arise as a consequence of DNA lesions.

🥚🔄🐓 - Another narrative of our last paper: communities.springernature.com/posts/r-loop...

Registration is open for a great meeting in Potsdam, Germany (July 23-27) ... for everyone interested in the biology of the nuclear envelope and related topics (events.gwdg.de/event/1012/)

DNA lesions can frequently precede DNA:RNA hybrid accumulation Nature Communications - DNA:RNA hybrids are linked to genetic instability in several pathological situations. Here, the authors report that various types of DNA lesions can trigger hybrid formation...

Read more here: rdcu.be/ecYmz (8/8)

Much grateful to @agencerecherche.bsky.social , @fondationarc.bsky.social and Ligue Nationale contre le Cancer for funding this project ! (7/8)

Congratulations to first author @raphaelmngn.bsky.social and many thanks to all our great collaborators 🧑‍🎓 - Rodney Rothstein @columbiamed.bsky.social, Sergio de Almeida @gimmfoundation.bsky.social, Peter Stirling @BCCancer and Pierre-Henri Gaillard @crcm.bsky.social (6/8)

Such « post-lesion » hybrids can be detected in yeast and human cells, yet they do not detectably impact genome stability, as opposed to « pre-lesion » hybrids - a revisited classification? (5/8)

For example, focusing on Okazaki fragments (OF) processing, we found that the accumulation of unprocessed flaps or unligated OF termini is the source of hybrid formation 🧬 (4/8)

We identified several situations where DNA:RNA hybrids are associated with genetic instability – strikingly, in most cases, DNA lesions appear to precede hybrid formation 🔃 (3/8)

In this study, we systematically explored the relationships between DNA:RNA hybrid formation and genetic instability, through a suite of genetic screens in yeast 🧬 (2/8)

Pleased to launch the Palancade lab Bluesky account with our new paper 📝, now out at @naturecomms.bsky.social (1/8)