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Immune dysregulation in prolonged Long-COVID: lymphocytes emerge as key mediators of persistent inflammation, exhaustion and cytotoxicity - Journal of Translational Medicine Background Long-COVID affects at least 10% of COVID-19 survivors, displaying debilitating symptoms across multiple organ systems. Despite the widespread prevalence, Long-COVID aetiology remains poorly understood, but emerging evidence points to immune dysregulation as a potential mechanism involved in its development or persistence. Methods This study presents a unique analysis of the peripheral blood mononuclear cell transcriptomic profile of COVID-19 and Long-COVID patients at single-cell resolution. We reconstructed the cell state and intercellular communication using differentially expressed gene profiling and ligand–receptor interaction analyses. Results Our results reveal altered T and natural killer cell subset proportions, diminished proliferating lymphocyte and B cell signalling capacity, and the expression of exhaustion and cytotoxicity associated genes 1.5–2 years post-infection, suggesting incomplete immune recovery. Distinct interferon responses in these cell populations at the acute phase for patients who go on to develop Long-COVID indicate early disease mediator potential. Conclusions Collectively, these findings provide insight into the immune processes underlying the progression of COVID-19 into a chronic Long-COVID state. The observed changes in immune cell subsets at the acute phase of the infection may be predictive of Long-COVID progression and could be useful in understanding disease aetiology while the observed long-term effects are crucial to developing therapeutic and diagnostic tools.

COVID is immune damaging. What's concerning is the duration of dysregulation

doi.org/10.1186/s129...

Frontiers | Reduced cortical brain perfusion following COVID-19 infection: impact of COVID-19 severity and relation to memory performance IntroductionChanges to brain perfusion may be contributing to long-term cognitive dysfunction following COVID-19 infection. Lower brain perfusion beyond the ...

🧠 Daily Feed of Brain Damage 🧠

Hypoperfusion

doi.org/10.3389/fnhu...

It is a scam to steal away more of our collective tax dollars. Just like the concentration camps immigrants are now in. Costing us BILLIONS. MONEY THAT COULD BE USED FOR GOOD THINGS, just being siphoned away from us.

Immigrants never cost us so many billions before. These camps are big biz.

The idea that locking people up in for profit internment camps will be cheaper that providing healthcare and housing is a scam. We are spending many billions of taxpayer $$$$$$ locking up immigrants.

We are being scammed. These horrid camps are HIGHLY PROFITABLE. Our taxes making the rich richer.

I’m stupid tired. I better get some sleep. Those guys are jeerks. That’s my new word tonight. Best!

School Difficulties and Long COVID in Children and Adolescents Pediatric Long COVID (LC) is an infection-associated chronic condition following SARS-CoV-2 infection. While research has begun to elucidate clinical phenotypes, functional impacts are not well descri...

School Difficulties and Long COVID in Children and Adolescents

Published: April 2, 2026

A new study shows Long COVID in kids is linked to school struggles—attention, learning and social issues. It highlights the need for early recognition and better school-based support to help affected children.

Are these genuine? If so, why didn’t Iran release them sooner? Why haven’t others released them?

Since Trump has trouble distinguishing what someone in the medical profession looks like, here is a picture of a lifesaving professional.

Another pardoned Jan. 6 rioter to admit guilt in child sexual abuse case David Daniel has reached a plea agreement with federal prosecutors after a judge ruled that President Donald Trump's pardons in the Capitol attack didn’t apply to child exploitation.

ABSOFUCKINGLUTELY UNFUCKINGBELIEVABLE 😳

This piece of shit thought Trump's pardon covered his child abuse charges as well. 😳
And why the hell not eh, since everyone else is getting away with child rape, molestation, sexual abuse and other crimes against children.
www.nbcnews.com/politics/jus...

It’s still fun to gloat though. At least a little. Give us something please.

But for a while it looked like they were pinning their future on her.

Totally. A little one.

Theil has so many chips though. But still, Vance is doomed to be relegated to online punditry after this. He’ll get all the blame dumped on him for Trump’s crooked failings.

Turning Point reaching a turning point.

Trump lost his war on Iran, bigly His nonstop bullshitting can't change the facts on the ground.

New in PN: Trump lost his war on Iran, bigly

"The ability of the free press, much less regime propagandists, to grapple with the scale of the loss & its implications is very much in doubt. It’s worth, therefore, laying out the nature of the defeat, who's unwilling to describe it as such, & why."

He’s pretty far into dementia. It looks to be accelerating, as in getting worse faster and faster. Can he even keep track of ideas? Just so strange all these Republicans still afraid to speak up, they’re tangled in his coattails or being blackmailed? I don’t get it, they’re killing their careers.

Can you explain what you mean? What’s a Zionist?

This. Is. A. Lie.

He’s sitting on millions of documents.

Erica Payne, founder of @patrioticmillionaires.org: "Doing it around the edges is what got us this freak show in the WH sending out memes about him being Jesus & getting in a fight with the Pope in a country that prides itself on the separation of church and state. For heaven's sake! Enough already"

She’s got such a weird vibe, plus that’s a group that thrives on sexism—I don’t think she’s their long-term hero. They’ll fizzle.

He’s probably destined to be the fall guy for all of Trump’s failings once Trump does or becomes so dementia-riddled that they can’t hide it. He got confused by the door dash delivery and thought it was pizza in the middle of him trying to get fake grandma to say stuff bad about trans athletes.

Reagan's GOP liked to call their coalition a "three-legged stool" made up of the Religious Right, libertarians and anticommunists.

Trump's GOP has its own coalition, but it's made up of white supremacists, pedophiles and traitors. And its leaders are often all three!

He got the stool part right. The coalition is a stool.

He should book a library meeting room. He could just about fill one.

Jesus. These are crimes like the president did. Lock him up too?

And all the men who knew and did nothing. And Swalwell (stupid name that I’ll be glad to be done with) he apparently thought he could just be a public figure and get away with it as if he’s Trump. All the dirckhead ra pist politician men should take note.

Orban copied Trump. Trump copied Orban.

And in the end, the people of Hungary chose democracy and the rule of law. As will happen here too. But only if we do our work, like they did.