I am so sorry, my condolences to Dr. LeMosy's family.

Oh my gosh, this this this. These enshittified search engines are like futilely shouting "representative" at the automated voice messaging gremlins.

If I wanted to get a HaloTag-ged version of a protein not currently in Promega's catalog, is that something I can custom order from them? Or another vendor? I'm not clear from their custom assay services blurb whether that's an option or not.

New FeiginLab paper is OUT! A commonly prescribed anti-anxiety drug reduces inflammatory signaling in pancreatic cancer through regulation of cancer-associated fibroblast activity!

aacrjournals.org/cancerrescom...

*cackles in old gamer*

As a recipient of federal grants from #NIH (for now! 😭) that funds research in my lab, I'd like to sincerely thank American taxpayers on #TaxDay for investing in scientific research that lays the foundation for medical and technological innovation in this country and keeps us ALL safe and healthy

In hell trying to pull data together and it would be totally unnecessary if people would report an accession number of any kind!

Any recommended alternatives to PhosphoSitePlus now that they're not issuing academic licenses anymore? I need non-phospho datasets.

NSF names record number of graduate fellows, rebounding from 2025 dip Distribution by field is also closer to the norm than last year’s class

NSF names record number of graduate fellows, rebounding from 2025 www.science.org/content/arti...

Median survival went from 6 months to 13 months. It may not sound like much, but for metastatic pancreatic cancer, this is big, IMO. We finally have something solid to build on in this field.

Multiplexed Isothermal Amplification Assay for the Detection of Plasmodium falciparum and Trichomonas vaginalis in Urine Trichomoniasis and malaria, caused by Trichomonas vaginalis (T. vaginalis) and Plasmodium falciparum (P. falciparum), respectively, remain major public health threats, primarily in resource-limited regions like sub-Saharan Africa. In particular, malaria in pregnancy (MiP) poses serious diagnostic challenges due to the placental sequestration of P. falciparum, often leading to underdetection by conventional tools like microscopy or rapid diagnostic tests (RDTs). Meanwhile, T. vaginalis, the most prevalent nonviral sexually transmitted infection, exacerbates poor maternal and fetal outcomes when co-infections occur. In this study, we present a multiplexed isothermal nucleic acid amplification assay (iso-IMRS) for simultaneous detection of P. falciparum and T. vaginalis. We built on prior work validating iso-IMRS for P. falciparum and PCR-IMRS for T. vaginalis using a modified workflow better suited to near point-of-care (POC) settings. The assay was tested in simulated and human urine matrices, aiming for a low-cost, non-invasive, and field-ready diagnostic solution. The assay detected P. falciparum and T. vaginalis at 100 copies/μL in processed human urine, demonstrating clinically relevant sensitivity for noninvasive, multiplexed detection. However, use with a neat urine sample requires a processing step that may limit POC use. In our clinics in Kenya, we process samples nearby, and a fast molecular test that does not require thermocycling, with a turnaround time within the span of a typical prenatal visit, will positively impact our patients.

New diagnostic to detect Malaria in Pregnancy (MIP) - which is hard because the parasite likes to sequester and hide in the placenta!

Multiplexed Isothermal Amplification Assay for the Detection of Plasmodium falciparum and Trichomonas vaginalis in Urine | ACS Omega pubs.acs.org/doi/10.1021/...

Diffusive spreading across dynamic mitochondrial network architectures | PNAS In eukaryotic cells, mitochondria form networks that range from highly fused interconnected structures to fragmented populations of individual orga...

Excited to share a new collaborative paper with Lena Koslover's team, fueled by @chanzuckerberg.bsky.social Metabolism Across Scales Program 🧪 1/
www.pnas.org/doi/10.1073/...

I do not understand how *every* mechanism I review grants for requires me to submit detailed feedback, yet everything I apply to is just like yeeting science into the void.

NSF COA affiliation finder script NSF COA affiliation finder script. GitHub Gist: instantly share code, notes, and snippets.

There is one! gist.github.com/esteng/51604...

a woman is crying while holding a napkin in front of a box with the letter i on it ALT: a woman is crying while holding a napkin in front of a box with the letter i on it

CARROLL

Only time I'll be rooting for the Turkey Mafia of Cambridge!

A Waymo self driving car is parked next to the protected bike lane on Brattle St in Cambridge MA. A male turkey is standing in the street next to it, aggressively displaying its tail feathers.

The fight we’ve been waiting for, the Battle of Brattle: Waymo vs. Cambridge turkey.
@universalhub.com

This is so, so well-articulated.

Vote for an addendum to include glycosylation 😂

The Orange Cat Brain Atlas is here. 🧠🐈

Today, we published the first comprehensive cellular map of the orange cat brain. The new atlas reveals a single, specialized neuron responsible for behaviors like staring at walls, knocking objects off tables, and the 3am "zoomies."

Spike of flowering purple orchids draped across book standing upright. The book is entitled "Menewood" by Nicola Griffith. The book cover features a flaxen-haired woman holding a sword pose.

I feel like Hild would have approved of this impromptu usage of her story! @needhibhalla.bsky.social it was indeed an amazing read!

A sleek yellow dog lies on a couch, surrounded by quilts and blankets, sniffing the cover of the New York Times magazine, which features her friend Dora pulling a sled through the snow in closeup

After inspecting the magazine, the yellow dog, Flame, looks up at the camera with a look of disbelief

Flame cannot believe that Dora is on the cover of today’s new york times magazine instead of her

Scientists Filmed a Whale Birth. The Surprise: Mom Had Many Helpers.

“11 sperm whales huddled together at the surface, strangely still and taking occasional shallow dives. After about an hour, the animals seemed to start thrashing, and a plume of blood reddened the water. The researchers feared trouble, maybe a shark attack. But it was something else.”

WHALE DOULAS!

Amazing, congratulations!!!🎉🎉🎉

This eyewitness account of the Triangle Shirtwaist fire always brings me to tears
(read the whole thing trianglefire.ilr.cornell.edu/index.html)

Oh no, I am so sorry Rebecca. I am glad she was home and surrounded by love and all her favorite things.

A slide called: 'Clinical trial registration: Looking back and moving ahead'; on the left are a list of journals listed with their impact factors and number of citations the named article received in that journal. On the right is a plot of numbers of citations vs impact factor.

Exactly the same article (same text, same authors) published in a range of journals at roughly the same time. Number of citations correlates (somewhat) with impact factor of the journal it was published in. Except in Croatia...

The dialogue was always had an affect, but it felt especially pronounced/unrealistic this season? The characters also felt off, still like the show but it was a slog this season.

1/ Hot take: deep learning is overkill for 90% of bioinformatics problems.

I've watched teams spend months building neural networks that get outperformed by XGBoost trained in an afternoon.

Here's why simpler models keep winning.