This. A thousand times this.

🩸La leucemia linfoblástica aguda B es uno de los cánceres infantiles más frecuentes

🧬Una alteración en el cromosoma 9 está presente en el 10% de los pacientes

🔬Un estudio de @ciccancer.bsky.social  muestra el papel clave de esta mutación en la evolución de la enfermedad

➡️ http://tiny.cc/4bw0101

An updated view on lagging strand DNA replication: implications for the replication stress response The process of DNA replication is inherently asymmetric. While the leading strand is synthesized continuously, the lagging strand is copied in small fragments, the Okazaki fragments, requiring the ...

Fresh from the oven! Our new perspectives article where we discuss the interplay between lagging strand DNA replication and the replication stress response.
An updated view on lagging strand DNA replication: implications for the replication stress response www.tandfonline.com/doi/full/10....

a woman and a man. Text: "Our first global fellow postdocs"

We welcome our first global fellows: Sakshi Shambhavi and @jmartcan.bsky.social.
Our new Global Fellow Postdoctoral Program brings researchers into multiple labs at once.

👉 Details: www.mdc-berlin.de/news/news/ou...

@leifludwig.bsky.social @simonhaas.bsky.social @helmholtz.de

Our first “Global Fellow” postdocs The Max Delbrück Center’s Global Fellow Postdoctoral Program aims to establish a structure to foster greater interdisciplinary research among different labs. Our first winners of the three-year fellow...

👏🏻👏🏻👏🏻
www.mdc-berlin.de/news/news/ou...

Functional equivalence of γ- and x-ray irradiation for long-term peripheral blood chimerism and acute myeloid leukemia transplant outcomes in mice Total body irradiation is routinely used for myeloablation before a mouse hematopoietic cell transplant. Widespread transition from 137Cs γ irradiator…

Institutions are phasing out gamma-irradiators, but can X-ray irradiators replace them for mouse transplant models?

We report that with proper dose calibration, X-ray conditioning produces equivalent hematopoietic chimerism and AML transplant outcomes. Encouraging news!

🔗 doi.org/10.1016/j.ex...

Este viernes, a las 19:30, en Alcobendas, hablaremos de Enfermedades Raras: Qué son y Cómo se Investigan

Despedimos el año de la mejor forma posible: anunciando nuestra charla de enero 😊

🤒Las enfermedades raras: Qué son y cómo se investigan
🧑‍🏫 @cjchcm.bsky.social de @cbm-csic-uam.bsky.social
🗓️V 16-Enero-26
📍Arrocería Casa Valentina (Alcobendas)

¡Tenemos un ponente excepcional! No te lo pierdas ⬇️

Molecular Mechanisms of Childhood Leukemia Development - Centro de Biología Molecular Severo Ochoa Job Description We are seeking a highly motivated postdoctoral researcher to join our laboratory to study the early steps of development of childhood B-cell Acute Lymphoblastic Leukemia (B-ALL). The p...

📢¡Oferta de trabajo en el CBM!
El grupo de César Cobaleda busca postdoc para estudiar cómo se origina la leucemia infantil (B-ALL).
💡 Proyecto “la Caixa” Research Health 2025
🧬 Modelos murinos, epigenética, célula única
📅 Deadline: 5 dic 2025
www.cbm.uam.es/index.php/jo...
@cjchcm.bsky.social

On #WorldBlood#CancerDay, let’s remember those affected and raise awareness about these diseases. Explore the main types of blood cancer and how they impact the body 👇

🔗 https://bit.ly/4kkBfvA

#HemeSky #MedSky #HemeOnc

📣 We are super happy to share our new preprint!
We show how an imbalance between replication and transcription elongation rates can be uncoupled genome-wide without replicative stress 1/3

Once you have enough knowledge of the literature in your research field, you realize you’ll never have enough knowledge of the literature in your research field.

I am not necessarily against the initiative, but would a chimpanzee with 20 gene edits be human?

If you lined up a dire wolf genome with a gray wolf genome there would be millions of differences. These individuals seem optimistically 1/100,000th dire wolf. (No paper or preprint available though).

Federico Mayor Zaragoza obituary: former UNESCO chief who championed neonatal screening The biochemist introduced the first heel-prick tests for newborn babies in Spain, protecting infants from life-changing metabolic conditions.

www.nature.com/articles/d41...

Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis - Nature Communications Shortages of donor blood for transfusions can have severe medical consequences, and ex vivo production of red blood cells offers a potential solution. Here authors developed synthetic EPO receptors, w...

www.nature.com/articles/s41...

Meinrad Busslinger, Emeritus Senior Group Leader at the IMP, received the Silver Medal for Meritorious Service to Vienna for his outstanding scientific achievements & key role in establishing the IMP and Vienna BioCenter. 🎖️👏

Read more: www.imp.ac.at/news/article...

@viennabiocenter.bsky.social

The contentious genius who made black holes real Roger Penrose, now 93, never shied away from wild ideas and the ensuring debates. The first full-length biography reveals more about the mathematician and the man.

www.nature.com/articles/d41...

Evidence of oldest known alphabet unearthed among Syrian tomb treasures Cylinders discovered in 2004 are inscribed with the earliest known examples of letters, say archaeologists.

www.nature.com/articles/d41...

Long-term lineage commitment in haematopoietic stem cell gene therapy - Nature Haematopoietic stem cell (HSC) clonogenic activity, lineage output, lineage commitment and somatic mutation rates are influenced by the underlying disease, patient age, extent of genetic defect correc...

www.nature.com/articles/s41...

We used to hear the term "tired blood." [Geritol]
Now it's tired proteins. Proteolethargy. Reduced protein mobility as an underpinning for chronic diseases
www.cell.com/cell/abstrac...

In the end, it comes down to whether one believes the system generally allocates resources in ways that predict rather than fuel success. Between the tails of the distribution, I don’t think it does.

Loss of Earth’s old, wise, and large animals Earth’s old animals are in decline. Despite this, emerging research is revealing the vital contributions of older individuals to cultural transmission, population dynamics, and ecosystem processes and...

No planet for old animals 😢

www.science.org/doi/10.1126/...

The metaphors of artificial intelligence A few months after ChatGPT was released, the neural network pioneer Terrence Sejnowski wrote about coming to grips with the shock of what large language models (LLMs) could do: “Something is beginning...

www.science.org/doi/10.1126/...