Using single-H1 imaging and computational modeling, we show that most H1 behaves like a liquid inside chromatin domains rather than binding stably to nucleosomes as in the textbook model:
www.science.org/doi/10.1126/...
Congrats
@masaashimazoe.bsky.social & all contributors! 🎉 2/

Congratulations! Fantastic paper!

I am not afraid to say it: this is the most fundamental advance in our understanding of chromatin structure since the zig-zag fiber model. Congratulations!

Direct visualization and tracing of chromatin folding in the Drosophila embryo - The EMBO Journal Chromatin organization, through the assembly of DNA with histones and the folding of nucleosome chains, regulates DNA accessibility for transcription, DNA replication and repair. Although models deriv...

We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ

link.springer.com/article/10.1...

Template Learning: Deep learning with domain randomization for particle picking in cryo-electron tomography - Nature Communications Particle picking is a key bottleneck in bridging structural and cell biology with cryo-electron tomography. Here, authors develop Template Learning, using domain-randomized simulations to train deep l...

Generate synthetic cryo-ET data and train your model for particle picking in real data.
Impressive work by Mohamad Harastani:
www.nature.com/articles/s41...

Thanks a lot! Congrats to your EMBO J paper!

A question for the experts: Can you recognize nucleosomes and linker DNA in this data?
Find an updated version of our manuscript in
www.biorxiv.org/content/10.1...