Frontiers | Mu-opioid and nociceptin receptors show divergent, cell-type-specific actions in the mesocorticolimbic reward system in opioid use disorder The mu-opioid receptor (MOR) and the nociceptin/orphanin FQ receptor (NOPR) are closely related yet functionally distinct modulators of rewards, motivation, ...

🚨 New review out! We summarize how MOR and NOPR exert divergent, cell-type-specific control over VTA-NAc-PFC circuits in opioid use disorder www.frontiersin.org/articles/10....

Dopaminergic mechanisms of dynamical social specialization - Nature Longitudinal tracking of mice reveals that stable, specialized social roles emerge spontaneously within groups during a foraging task, with dopaminergic activity in the ventral tegmental area driving ...

New paper in Nature, @nature.com (go.nature.com/4c4OjCj) : how do social roles emerge in groups of near-identical individuals ? we find that they are neither predetermined nor fixed.

Untangling the multifaceted VTA responses to stress

"Untangling the multifaceted VTA responses to stress"
http://dlvr.it/TPKFpf

@dralexharris.bsky.social @ampolter.bsky.social & Urszula Skupio
@cp-trendsneuro.bsky.social
#SfN2025

Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind - Nature Neuroscience Differences in neuroeconomic decision-making influence nucleus accumbens dopamine dynamics and reflect choice confidence during evaluation, as well as past and future value during re-evaluation, which...

Dopamine dynamics in the nucleus accumbens core reflected decision confidence during evaluation of decisions in an economic foraging task in mice, as well as both past and future value during re-evaluation and change-of-mind

@perothwell.bsky.social

www.nature.com/articles/s41...

Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner Long non-coding RNA LINC00473 in mPFC alters change-of-mind re-evaluative decision-making behavior related to negative rumination.

New paper alert!🚨📝

Paper: tinyurl.com/2cycsy6d
Press release: tinyurl.com/yur3j2n8

How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances

Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety-like behaviors - Nature Communications Drugs of abuse exert both motivational and emotional effects. Here, the authors show that nicotine and ethanol activate a VTA–NAc loop that inhibits dopamine neurons projecting to the amygdala, thereb...

Nicotine doesn’t just “turn on” the brain’s reward circuits — it reshapes them. Our new paper in Nature Communications shows that activating reward-linked dopamine neurons also sets off a feedback loop that drives negative emotional states.
www.nature.com/articles/s41...

Excited to present the latest from the lab out today in Cell www.cell.com/cell/fulltex.... See Thread! 1/8