Come listen to my talk about how enhancers evolve and how promoters emerge from randomly synthesized DNA sequences!

Our next speaker will be Timothy Fuqua @timothyfuqua.bsky.social with "The Evolution and Emergence of Regulatory DNA", 14th April, 5PM CET.
Sign-up here:
tinyurl.com/prose-seminar2

Our next Talk will be "Protein Origami and the Hidden Rules of Functional Innovations"! March 11th, 5PM CET. Sign-up here: tinyurl.com/prose-seminar2

ProSe goes into the 2nd with a talk by Vyacheslav Tretyachenko on the pervasive alternative translation in the human proteome. Join us tomorrow via Zoom, 4PM GMT, 5PM CET.

Next up in our ProSE seminar series: Vyacheslav Tretyachenko on alternative translation in the human proteome
Register to join: tinyurl.com/prose-seminar2
Past seminars: tinyurl.com/ProSE-videos

Check out our new review in Nature Reviews Genetics on de novo emerged genes and proteins. How they emerge, are lost and persist - and how de novo emerged proteins relate to randomized proteins! @bornberglab.bsky.social www.nature.com/articles/s41...

Emergence and evolution of protein-coding de novo genes Nature Reviews Genetics - De novo gene evolution entails the birth of new genes from previously non-coding DNA. In this Review, Bornberg-Bauer and Eicholt overview how protein-coding de novo genes...

New review out in Nat Rev Genet: Emergence & evolution of protein-coding de novo genes by Erich and Lars Eicholt @lacholt.bsky.social. How non-coding DNA becomes translated, persists or is lost in populations, and can yield structured/functional proteins—plus methods & open questions! rdcu.be/e09SM

🚀We’re excited to share our new paper in Bioinformatics!

We introduce a user-friendly toolkit that implements our novel DeNoFo file-format for standardised annotation of de novo gene detection workflows — enabling reproducible methodology descriptions and easier dataset comparison across studies.

Join us tomorrow! Joana Pereira is talking about AI-powered classification and discovery across the protein universe. @joanampereira.bsky.social

5PM CET, link in the post and in our bio.

The DeNoFo format & toolkit for annotating, assessing and comparing the tools and tresholds used in studies of de novo evolved genes is out now in Bioinformatics! Great effort led by @drdomain.bsky.social and Anna Grandchamp!

academic.oup.com/bioinformati...

Protein Structure Evolution Seminar November 11, 5pm CET Title: AI-Powered Classification and Discovery Across the Protein Universe Speaker: Joana Pereira Organized by: Claudia Alvarez Carreno, Zachary Ardern, Lars Eicholt, Carolina Sanchez-Rocha, Sergio Romero-Romero and MD. Hassan Uz-Zaman

The next ProSE Seminar will be given by Joana Pereira @joanampereira.bsky.social (VIB, KU Leuven)
🗓️ November 11th, 5pm CET

Registration is now open: tinyurl.com/prose-seminar2
Please share!

@claudiaalcar.bsky.social

@caro-rocha.bsky.social

@lacholt.bsky.social

@zachary-ardern.bsky.social

@romeritos.bsky.social

@hassanzaman.bsky.social

Our speakers so far were:
- Andrei Lupas
- Zachary Ardern
- Devlina Chakravarty
- Klara Hlouchova
- Sophie Heidig
- Nir Ben-Tal
- Stephen Fried

Protein Structure Evolution (ProSe) Seminar is now on BlueSky! Every 2nd Tuesday, 4PM GMT.

Sign-Up: tinyurl.com/prose-seminar2

Organized by Claudia Alvarez Carreño, Zachary Ardern, Lars Eicholt, Carolina Sanchez-Rocha,
Sergio Romero Romero and Md. Hassan Uz-Zaman.

The next Protein Structure Evolution Seminar will be given by Stephen Fried (JHU):

Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t”
Date: October 14th, 5 pm CET
Registration link: tinyurl.com/prose-seminar2