Advertisement · 728 × 90

Posts by mike freund

Preview
Hopeless in Tehran Essays on neuroscience

Today I received a note from a grad student who lives in Tehran. Her note gives you firsthand experience of what it’s like to live in a city that is being bombed, and what it’s like to be young and feel despair about your future.

rezashadmehr.blogspot.com/2026/03/hope...

1 month ago 169 75 5 7
how does his brain do it ? #neuroscience #memory #sport Nelson Dellis 6x US memory champion
how does his brain do it ? #neuroscience #memory #sport Nelson Dellis 6x US memory champion YouTube video by Roselyne Chauvin

The 6x US memory champion – Nelson Dellis – can memorize a deck of cards in 40 seconds and knows the first 10K digits of pi.
To figure out how, he let us peak inside his brain. Here is what we learned in our precision brain mapping study www.biorxiv.org/content/10.6...

youtube.com/shorts/MryMq...

1 month ago 81 32 5 7

An Efficient Computing Theory of Prefrontal Structured Working Memory Representations www.biorxiv.org/content/10.64898/2026.02...

2 months ago 12 4 0 1
Preview
Live updates: Two deceased in active shooter incident at Brown University Serving the Brown University community since 1891

Kudos to the Brown University students who are posting continuous live updates, spaced just minutes apart, on the campus shooting. A lot of grace and professionalism under immense pressure.

www.browndailyherald.com/article/2025...

4 months ago 2746 690 32 29

How does this stim protocol compare to what is used in human studies?

4 months ago 1 0 1 0
Post image Post image Post image

Ellis starting the day off by reading out Carl Sandburg's poem "Chicago" in its entirety.

5 months ago 650 168 7 71
Preview
Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation - Nature Neuroscience Working memory improves during adolescent brain development. Zhu et al. tracked monkeys through adolescence, revealing that maturation of white matter tracts and refinement of neural firing patterns s...

New paper from the lab:
www.nature.com/articles/s41...

A brief thread (1/10)

5 months ago 38 13 2 1
Video

I made a video about the shutdown, and why this government worker won’t be a pawn.

When the president and Supreme Court are both acting lawlessly, Congress must stand up and stop it.

US science is collapsing and Congress needs to act.
🧪
Full video here: www.instagram.com/reel/DP1tXXE...

6 months ago 106 40 5 2
Advertisement

I'm really curious what factors drive var(nTc). Both from basic perspective, but also from practical -- of someone that wants to put these dynamics under tighter experimental control / to have more certainty about what's happening when :)

7 months ago 0 0 1 0

It is so interesting that the nTc is so variable across trials.

But this is also sobering: clearly, time-aligned trial averaging has *deep* flaws -- yet so much of human cog neuro relies on it, due to unavailability of high-SNR recordings...

7 months ago 0 0 1 0
Preview
Transitions in dynamical regime and neural mode during perceptual decisions - Nature Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...

How does the brain decide? 🧠

Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.

After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.

rdcu.be/eGUrv

7 months ago 250 97 13 2
Preview
AAUP-UC-Trump Lawsuit -- Uploaded by Jaweed Kaleem of the Los Angeles Times

I'd like to commend the lawyers who wrote this complaint on behalf of the professors and employees of the University of California against the Trump administration.

It's a sober legal document with strong claims, but also, this is a fight for public opinion, and this reads like the writers know it.

7 months ago 424 131 5 16

You sound like an all-American to me !

7 months ago 0 0 0 0

post-script: "all-american upbringing" seems to preclude this usage

7 months ago 0 0 1 0
All-America - Wikipedia

i think it could have a variety of connotations (see other comments), but one dominant usage is in reference to being competitive in athletics or academics on national scale, a la en.wikipedia.org/wiki/All-Ame...

7 months ago 0 0 1 0
Preview
Q&A with Nico U.F. Dosenbach and Roselyne Chauvin Nico U.F. Dosenbach and Roselyne Chauvin spoke with Cell Reports about their recent paper, in which they observed subcortical plasticity in humans following a 2-week arm/hand-casting paradigm with dai...

Want to know the behind the scenes of the "Disuse-driven plasticity in the human thalamus and
putamen" paper? discover @ndosenbach.bsky.social and I interview by @cp-cellreports.bsky.social

www.cell.com/cell-reports...

7 months ago 18 5 1 0

…Btw I do not mean to suggest there is no worth to mixed-selective perspectives, or that they are wrong! Personally I have just struggled when thinking about how exactly to provide strong positive evidence for them. And curious to hear your perspective.

7 months ago 1 0 1 0

You can’t be, until you find one :) Its existence is not guaranteed. The same I do not think is true for the mixed basis case. IMO, this is what often makes it compelling when an interpretable factorized basis is identified.

7 months ago 1 0 1 0
Advertisement
Preview
Frontal cortex neuron types categorically encode single decision variables - Nature Frontal cortex neurons can be grouped into categorical response types corresponding to particular decision variables, such as reward size, decision confidence, or value, and individual variables may b...

What appears mixed and non-linear from one basis could be sparse & factorized from another. When you see mixed selectivity, how can you be confident that your basis isn't just wrong?
doi.org/10.1038/s415...

7 months ago 2 0 1 0
Preview
Long-standing theoretical neuroscience fellowship program loses financial support Funding from the Swartz and Sloan Foundations helped bring physicists and mathematicians into neuroscience for more than 30 years.

I will always be grateful for the immense -- and unique -- contribution the Swartz Program made in supporting theoretical neuroscience over the past 30 years. Its closure leaves a profound void. doi.org/10.53053/FPR...

7 months ago 8 2 0 0

What is this, a fitness test for Presidents?

8 months ago 1 0 0 0
Video

via Benedicto.Uribe on TikTok

10 months ago 15223 3795 427 334

The conditions that have led to what’s happening in the US today exist in democracies around the world.
They are an inevitable outcome of our collective failure to adapt to fundamental changes in the information ecosystem on which our democracies were originally built.

10 months ago 5685 1818 159 270

Fully agree. Our story feels incomplete to me without those things, but we simply had to get it out the door. But, I think Todd & co. are working on those follow-ups now!

10 months ago 2 0 1 0

of course, don't mean to imply that one method is better or more sensitive in general than the other (that depends on exp design & theoretical questions). just that they can be sensitive to different neural features.

10 months ago 1 0 1 0

:) Borne mostly from reflecting on reactions from family/friends ("you're STILL in school/a student?!") --- yes, aren't we all?

10 months ago 1 0 1 0

(...but correct me if i'm misremembering)
So the decoders we used didn't require the neural signatures to be aligned across subjects, but only across sessions w/in subject. Seems likely that at finer spatial scales, multi-subj decoders would lose sensitivity more quickly than subject-specific ones.

10 months ago 0 0 1 0

hey thanks for mentioning David! Interesting ideas in this thread. Yes we were able to identify relatively reliable signatures at the region level. One potentially relevant difference btw our studies: our decoders were subject-specific, whereas yours were fitted on data from multiple subjs, IIRC.

10 months ago 0 0 1 0
Advertisement

It's a demoralizing time to be a US scientist but that is part of their strategy. My friend Jeff Dangl just emailed our faculty reminding us that NSF and NIH grant review panels are still being held and staff there want us to keep submitting. Stay engaged and keep fighting! 1/n

11 months ago 291 72 10 3
Post image

Our paper in @natcomms.nature.com, we show how cognitive maps in the hippocampal system could solve the general problem of representing and relating multiple alternative action plans. 
doi.org/10.1038/s414...

With @doellerlab.bsky.social, Patrick Haggard, @vigano.bsky.social, Daniel Reznik

11 months ago 94 30 7 1