Scientists at St. Jude developed patient-derived 3D tumor organoids and matched xenografts that preserve the molecular, genetic and cellular complexity of embryonal pediatric brain tumors. These models can speed functional assays and preclinical drug testing. https://ow.ly/vjSw50YK26w
Run an MD simulation of any protein in the AlphaFold Protein Structure Database using AF-CALVADOS
Thanks to @sobuelow.bsky.social AF-CALVADOS is now on Colab
colab.research.google.com/github/KULL-...
The call including details on how to apply: https://candidate.hr-manager.net/ApplicationInit.aspx?cid=3010&ProjectId=158638&DepartmentId=19974&MediaId=4917 Job and person profile: https://employment.ku.dk/documents/job-and-personal-profile-bio.pdf
Do you want to be my boss?
We are looking for a new Head of Department
Our Department covers biology broadly, from molecular biophysics 🧬 to ecology 🌱 & biodiversity 🐋, and coordinates teaching in several BSc and MSc programmes🧑🎓
Located in Copenhagen, one of the world's most liveable cites 🚲 🌞 🌥️
Happy to announce that my institution, @irbbarcelona.org, is opening two group leader positions, 1 in chemical biology and 1 in structural biology, to strengthen our expertise in molecular sciences: please spread the word !
New preprint on how disagreement among variant effect predictors can help guide prioritization of proteins for experimental analysis
Work led by Nicolas F Jonsson in a collaboration with Joe Marsh.
Preprint:
doi.org/10.64898/202...
@vxh357.bsky.social @jmarshlab.bsky.social
1/6
Postdoc position: Computational Biophysics of Disordered Proteins, Lindorff-Larsen group, University of Copenhagen, Denmark https://tinyurl.com/REWIRE-PD Deadline May 3rd, 2026
We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins
We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social
tinyurl.com/REWIRE-PD
Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !
IDPSeminars is back TOMORROW! Come see @tanjamittag.bsky.social and @xsalvatella1.bsky.social ! Not to be missed!!
Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...
More functional data, many thousands of words removed, and a few other updates from last year's preprint.
It was a pleasure to write the review on the role of phase separation in transcription together with you, @bsabari.bsky.social, Mikayla and Ambuja. I learnt a lot!
Faculty retreat of @stjuderesearch.bsky.social today. We see evidence everywhere of how Jim Downing shaped the vision for St. Jude over the last twenty years. The results are cutting edge fundamental science, St. Jude Global and important new initiatives. Inspiring!
New preprint with work led by @asrauh.bsky.social in which we explore how double mutant cycles could be used to study molecular interactions in condensates, and highlight difficulties in extracting information about interactions from mutational experiments
www.biorxiv.org/content/10.6...
Graphical abstract of pre-print
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.
Second preprint of the year in which @sarahgersing.bsky.social from @rhp-lab.bsky.social mapped the effects of >7500 variants in glucokinase (GCK) on the interaction with the glucokinase regulatory protein so that we now have a 3D GCK scan (abundance, interaction, activity)
doi.org/10.64898/202...
Are you a junior scientist working in theoretical biophysics? @zamakany.bsky.social and I are organizing another workshop this fall here at @hhmijanelia.bsky.social. Travel and the workshop expenses are all covered!
tinyurl.com/yc66fawc
Seminar titles: Andrea Soranno (Single molecule spectroscopy of disordered regions and nucleic acids) and Bokai Zhu (Nuclear speckle rejuvenation to ameliorate proteinopathy).
IDPSeminars is BACK THIS WEEK!
Talks from Andrea Soranno and @bokaizhulab.bsky.social on Thursday! 1 pm EST / 7 PM European time!
Sign up here: forms.gle/3yCHeYvuuqLh...
And check out the full Spring 2026 schedule at idpseminars.com!
Nuclear speckle associated RRM-containing proteins are block copolymers. They make size-limited, ordered microphases, tens of nm in size comprising tens of molecules. Speckles are likely clusters or emulsions of distinct microphases and not macrophases www.sciencedirect.com/science/arti...
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Hey that’s us 🎉
Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
Iowa State Dept of Molecular Biology is hiring for biomolecular solution NMR facility staff #NMRchat #Chemjobs #Chemsky
(I am NOT the hiring manager for this position, but I will refer any questions you have to the appropriate person.) isu.wd1.myworkdayjobs.com/IowaStateJob...
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Help me spread the word about an opening for the Furino Chair in Bioengineering in the Department of Bioengineering at McGill University. We seek candidates focused on developing biotherapeutic approaches to cancer, including but not limited to mRNA vaccines, CAR-T, and immunotherapy. (1/3)
Re-boosting! The Dept. of Microbiology 🧫 at the University of Tennessee is hiring two 9-month faculty! Come join a vibrant and growing department located in the foothills of the Smoky Mountains! #microsky
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
Image of Toronto
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
