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Posts by Graham Dellaire

I hate giving out bank info - so in these cases if they can’t provide a cheque I waive the honorarium.

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Looks great! Two slices please 🙏

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And in Canada we had Much Music and some innovative college radio stations like UBC’s CITR and the long gone Coast 1040 am radio in Vancouver to bring all that richness of music and culture right to our home and for free. #GenXAndMusic #SymbioticRelationship

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Harnessing random peptide mixtures to combat multidrug-resistant fungal infections | mBio The rising prevalence of invasive fungal infections, particularly among immunocompromised individuals, has become a critical public health concern. However, antifungal drug development has not kept pace with this growing need, and treatment options remain limited to a small number of drug classes. The emergence of multidrug-resistant fungal pathogens, such as Candida auris, further exacerbates this crisis by reducing the efficacy of existing therapeutics and increasing the risk of treatment failure. In this study, we evaluate the antifungal potential of FK20, a random peptide mixture (RPM) composed of L-phenylalanine and L-lysine. FK20 displays potent activity against C. auris and other clinically relevant Candida species, impairs biofilm formation, and exhibits synergy with caspofungin. Importantly, FK20 limits the emergence of resistance and demonstrates therapeutic efficacy in a murine model of systemic candidiasis. These findings establish RPMs as a promising new class of antifungals with broad-spectrum activity and clinical potential against drug-resistant fungal infections.

🚨A random solution to a growing fungal threat🚨
Our work on random peptide mixtures reveals potent antifungal activity against multidrug-resistant pathogens like C. auris, with low resistance potential and strong biofilm activity.
Now out in mBio!
Congrats to John and Yael for the fantastic work 👏

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Fixed it...

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Now.. where can I get a tiny soldier statue like this one 👇 #KnickKnacksForThePoliticalWin #HardToTakeThisSerious #CanadianPoliticsIsJustyLooney

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GenX opining re: nostalgia about how things where socially or politically in the 80-90s is kinda funny to considering that outside of probably the most open and exciting music scene for the two decades - everything else sucked so hard (Cold War, record unemployment and inflation, HIV pandemic…).

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Fog here in Halifax

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Not sure why this hits so hard #GenX #StoicismOrJustBeingCynical

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Woah.
WOAH!
I mean…

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I had a dream about this … ie full modelling and antibody/CART design from mass spec peptide data de novo/in silico. 1st steps?

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1/ 🔬🧑‍💻 Tired of going back and forth between GUIs and code for your 3D image analysis needs? Would you like to keep your focus in one place (notebook), without sacrificing interactivity? Here’s a tool that can help!

3 days ago 31 14 1 0

Condolences 💐

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Ah… Spring in Halifax. 🌷🌱

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Hyperacute rejection-engineered oncolytic virus for interventional clinical trial in refractory cancer patients Recently, oncolytic virus (OV) therapy has shown great promise in treating malignancies. However, intravenous safety and inherent lack of immunity are…

Harnessing alpha gal syndrome to kill cancer cells* - but make it pig alpha gal and express it from an oncolytic virus.

*Cancer cured but can never eat pork again (an obvious caveat considering Lone Star Tick caused bovine alpha gal syndrome) www.sciencedirect.com/science/arti...

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Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

Super cool paper - MitoCatch for cell-specific-targeted mitochondrial delivery! www.nature.com/articles/s41...

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Congrats Dr. Aaron Goodarzi (@ U Calgary) and the cross Canada Team on their Biology to Prevention Grant awarded by CIHR and The Canadian Cancer Society on "Preventing lung cancers caused by combined exposures to radon and wildfire smoke". cancer.ca/en/research/...

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Speechless: The New Campus Revolution | Part I
Speechless: The New Campus Revolution | Part I YouTube video by CBC Docs

Pretty timely documentary from CBC - “Speechless” youtu.be/-Psrh_W_Ew0?...

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No pipeline yet… that’s the last chip for “BINGO” on the “I can’t believe it isn’t a conservative government” card.

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4th Canadian Zebrafish Research Community meeting Join 4th Canadian Zebrafish Research Community meeting, May 15, 2026. Learn more on Fourwaves.

🟣🎺 So who is going to the 4th Canadian Zebrafish 🦓 🐟 Research Community (CZRC) meeting in Montreal this May 15th, 2026? Abstract submission closes April 24 - so hurry! event.fourwaves.com/4czrc/pages

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Say waaat! Radiofrequency gene control - now a reality. Get your tinfoil hats ready.

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Nope - I hope the boomers can take time from looking down their nose at other generations long enough to realize they have been bamboozled by a carpet bagger.

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Alberta is NOT lifting the gas tax - #scriptflip

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a man wearing ear buds and a ring with the letter t on it ALT: a man wearing ear buds and a ring with the letter t on it

For a so-called climate conscious government, putting all bets on AI is a bad look.

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Womp, Womp...

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a man is sitting at a desk talking on a cell phone with the words show me the money written below him ALT: a man is sitting at a desk talking on a cell phone with the words show me the money written below him

So funding? Cause' the answer is always

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a woman in a hooded jacket and sunglasses is sitting in a crowd of people and making a peace sign . ALT: a woman in a hooded jacket and sunglasses is sitting in a crowd of people and making a peace sign .
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a baby is sitting on a table with his eyes closed and the words `` the struggle is real '' written next to him . ALT: a baby is sitting on a table with his eyes closed and the words `` the struggle is real '' written next to him .

Some of this is mental health related... and I wish I was joking.

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And you won’t own either… and when you pass on, there will be now record you existed. Gears in a machine, numbers drawn in sand, shadows in the wind.

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She also looks afraid… 🫤

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