Graphical abstract showing that NMDAR immunisation drives psychosis-like behaviour in mice, while clozapine reverses this. Upper panel: arrows show NMDAR immunisation producing a mouse exhibiting psychosis-like behaviour, with clozapine reversing this effect. Lower panels: anti-NMDAR antibodies bind neuronal NMDA receptors, which are then eliminated by microglia via phagocytosis, leading to psychosis. Clozapine restores NMDA receptor levels by reducing anti-NMDAR antibody levels, consistent with an immunomodulatory mechanism of action.

🥁🎉The Psychosis Collective proudly presents our first preprint

𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞

𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴

starring Le He & Harriet Feldman

www.biorxiv.org/content/10.6...

We wanted to understand how antipsychotics work. Thread🧵

we built squeakpose studio. now there’s a preprint so i can stop explaining it in slides.

modern computer vision. ultra-fast training and inference. model-assisted labeling. analysis out of the box. real-time edge deployment on whole frames at 120 fps (which felt reasonable at the time).

Lrat-Cre has long been used to mark Hepatic Stellate Cell

Take a look at Extrahepatic cells labelled in Lrat-Cre::NuTRAP🐭
Kidney
Adipose (GFP+)
Testis
Eye
Intestine (GFP+)🔥
Skeletal Muscle (GFP+)
Heart
Brain
Lung (GFP+)🔥

bioRxiv 2026
www.biorxiv.org/content/10.6...

Check out a new paper coming out of our lab published in @acerjournal.bsky.social!!

Cyp2e1 deletion in mice increases sensitivity to ethanol‐induced motor impairment and escalation of drinking behavior in the chronic intermittent ethanol model This study investigates the impact of global Cyp2e1 knockout and wild-type mice to explore the effect of altered ethanol metabolism on behavior and gene expression. Knockout mice demonstrated altered...

Check out my new paper on how Cyp2e1 deletion results in increased sensitivity to ethanol-induced motor impairment and increased drinking escalation in a CIE model:
doi.org/10.1111/acer...

Risk reshapes amygdala representation of choice Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is exemplified when animals curtail pursuit of a valued outcome that risks being punis...

for anyone interested in the amygdala and risky decision-making, check out our new preprint: biorxiv.org/content/10.1...

amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.

I'm deeply honored to share that I've been awarded a 2025 NARSAD Young Investigator Grant from @bbrfoundation.bsky.social .

I'm so grateful to my mentors & BBRF for continuing to support early career researchers during this tumultuous time. It will mean everything to scientists like me. 🥲

Congrats!

Yup. Microsoft automatically switched me to the $99.99/year version with Spicy Autocomplete. You have to go all the way through "cancel subscription" to be presented these options and get the $69.99/year one you actually chose.

Microsoft is going to price gouge you by adding their genAI to your subscription without your consent, and they are not transparent about how to avoid this bullshit.

Here's how to change your subscription back to "Classic" for a lower charge without Copilot: answers.microsoft.com/en-us/msoffi...

Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice

A wasp drinking a beer

Wasps love alcohol. They seek out alcoholic drinks, and survive even after drinking the equivalent of 5 L of vodka, because they are incredibly efficient at metabolizing ethanol, helped by duplication of their alcohol dehydrogenase gene. www.pnas.org/doi/10.1073/... #BedtimeScience 🍺🐝 🧪