Icahn School of Medicine at Mount Sinai Remains Among Top Institutions for NIH Funding

Mount Sinai has 13 departments nationally in the top 10
🔗 www.mountsinai.org/about/newsro...

RESPOND Center | Icahn School of Medicine

3 RESPOND Center faculty appear on the list
🔗 icahn.mssm.edu/about/depart...

#EmergencyMedicine #NIH #TeamScience

New Blue Ridge rankings! 📊 Always humbling to see these rankings; much gratitude for the team behind the numbers.
🔗 brimr.org/brimr-rankin...

Proud to see Icahn School of Medicine at Mount Sinai rise to #6 nationally in EM NIH funding (from #7). 🚀

@medsky.social @mountsinainyc.bsky.social

The positivity of the novel orphine substance N-propionitrile chlorphine, or "Cychlorphine" in fatal drug overdoses has increased since mid-2025 when the Chinese government placed nitazene analogues under generic control, per CFSRE

www.cfsre.org/nps-discover...

Perhaps counterintuitive: xylazine-positive patients had lower ICU admission rates and fewer early cardiopulmonary events. That complicates the narrative and should temper reflexive assumptions about severity.
#ClinicalToxicology
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Clinical pearl: opioid overdose + unexpected bradycardia should raise suspicion for xylazine exposure. Naloxone still treats opioid toxicity, but it will not reverse alpha-2 agonism. Expect atypical physiology.
#medsky
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Abnormally slow heart rate associated with xylazine-fentanyl overdose Researchers have identified bradycardia—an abnormally low heart rate—as a symptom of xylazine-opioid overdose. This breakthrough finding from the Icahn School of Medicine at Mount Sinai may help emerg...

This aligns with recent mainstream media reporting on “tranq” moving from street-level anecdotes to measurable clinical patterns, but adds rigor: analytically confirmed serum testing across 10 institutions, not police seizures or hearsay.
#PublicHealth
medicalxpress.com/news/2026-01...
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Key signal: xylazine detection clustered in the Northeast and was independently associated with bradycardia on arrival. Not hypotension. Not hypoxia. A specific physiologic fingerprint worth noticing.
#EmergencyMedicine
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Clinical factors linked to xylazine exposure in emergency department patients with illicit opioid overdose Background and aims Xylazine, an alpha-2 agonist used in veterinary anesthesia, is increasingly detected in the illicit opioid supply but little is known about the patient level factors associated w...

Our new paper out in Addiction from the multicenter Fentalog Study examines who is more likely to have xylazine detected in non-fatal opioid overdose presenting to the ED. This is patient-level toxicosurveillance. #Xylazine #medsky

onlinelibrary.wiley.com/doi/10.1111/...

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The Fentalog Study: A Subset of Nonfatal Suspected Opioid-Involved Overdoses with Toxicology Testing View substances detected in samples from patients experiencing a suspected opioid-involved overdose.

Clinically, the data argue against single-agent mental models of overdose. Airway risk, withdrawal trajectories, and naloxone response increasingly reflect mixed pharmacology rather than pure opioid toxicity. Practice needs to catch up. #EmergencyMedicine
www.cdc.gov/overdose-pre...

From a public health perspective, the Fentalog Study reinforces a core lesson: mortality curves flatten only when surveillance, toxicology, and policy move faster than the supply chain. Static dashboards miss dynamic epidemics. #medsky

This aligns uncomfortably well with recent media coverage highlighting xylazine and novel fentanyl analogs appearing in unexpected regions, long after they are entrenched in local drug markets. Signal detection is lagging consequence. #HealthJournalism
www.ndtv.com/world-news/s...

The Fentalog Study: A Subset of Nonfatal Suspected Opioid-Involved Overdoses with Toxicology Testing View substances detected in samples from patients experiencing a suspected opioid-involved overdose.

The updated CDC Fentalog Study dashboard is a sobering reminder that the opioid supply is no longer just “fentanyl.” Polysubstance exposure is now the rule, not the exception, and surveillance must evolve accordingly. #PublicHealth 🧵
www.cdc.gov/overdose-pre...

5/ Bottom line: fentanyl still rules, but the “other stuff” — novel benzos, veterinary sedatives, synthetic cannabinoids — is the stealthy threat changing overdose care. Full report: npsdiscovery.org #DrugTrends

The Fentalog Study: A Subset of Nonfatal Suspected Opioid-Involved Overdoses with Toxicology Testing View substances detected in samples from patients experiencing a suspected opioid-involved overdose.

4/ Clinically, this underscores why standard opioid panels miss the mark. LC-QTOF-MS detected >1,200 substances, catching dangerous adulterants missed by routine screens. Treatment must anticipate multi-drug toxicity. #EmergencyMedicine
www.cdc.gov/overdose-pre...

3/ Public health takeaway: street drugs are increasingly poly-drug cocktails. Testing found opioids + stimulants + sedatives in the same patient; this complicates outreach, naloxone use, and treatment planning. #OverdosePrevention

Benzodiazepine Co‐Exposure Among Patients Presenting to the Emergency Department With a Confirmed Opioid Overdose Background Simultaneous exposure to both benzodiazepines and opioids can lead to synergistic respiratory depression, complicating overdose management. Our objective was to report on the detection of...

2/ A related Fentalog publication last week in AEM noted how lab-made benzos are reshaping #overdose risk. Our data back it up: bromazolam is showing up in multiple cities — often alongside #fentanyl onlinelibrary.wiley.com/doi/10.1111/...

1/ 🚨 New TOXIC Fentalog quarterly report on multi-city toxicology testing shows fentanyl & other synthetic drugs dominate suspected overdose cases in US ERs. Findings offer a near real-time look at the street drug market. #medsky #PublicHealth 🧵
www.cfsre.org/nps-discover...

Publication: Black patients less likely than white patients to receive outpatient treatment referrals after #opioid #overdose ED visits, per ToxIC Fentalog study. Findings underscore need to address disparities in post-overdose care. ➡️ bit.ly/4l1hFE2
@jamanetworkopen.com @maninialex.bsky.social

🚨Publication Alert🚨 bit.ly/46U3nl6
#Xylazine found in 1 in 5 nonfatal #opioid #overdoses across 10 U.S. EDs, mostly alongside #fentanyl. Exposure highest in NE vs. rare in the West. Regional trends underscore need for targeted public health responses. #MedToxTuesday
@maninialex.bsky.social

🚨Publication Alert🚨These findings focused on the presence of para-fluorofentanyl (PFF) point to important differences in OD response/treatment linked to fentanyl analogs w/ sex-specific effects that merit further investigation. 📖https://bit.ly/3Gv0gp3
@ziadkazzi.bsky.social @maninialex.bsky.social

Disparities in Treatment and Referral After an Opioid Overdose Among Emergency Department Patients

Among patients with opioid overdose in emergency departments, Black patients received outpatient referrals less frequently than White patients, with rates of 5.7% versus 9.6%. https://ja.ma/44kiKjO

July 1. Day One.
- You will feel overwhelmed (That’s normal)
- Courage isn't the absence of fear
- Ask for help early and often
- Nobody expects you to know everything
- Efficiency comes with time
- Trust the process
💙 Welcome. We’ve got your back. #InternYear #Medsky

🚨HUGE SCIENCE WIN ALERT🚨

NIH Grants to be restored en masse!!! Thank you Judge Young for standing up for science!

#StandUpforScience
#SummerFightforScience

Tianeptine, or ‘gas station heroin,’ can be addictive and cause serious side effects

WASHINGTON (AP) — Health officials want you to think twice before buying one of those brightly colored little bottles often sold at gas stations, convenience stores and smoke shops. Sometimes called “gas station…

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Over the long term, proactive surveillance could shift care from reactive triage to prediction and prevention—offering a model for future responses to dynamic drug crises. #overdoseprevention

Fentanyl Analog Study Fentanyl and its analogs (fentalogs) are increasingly contributing to opioid overdoses and deaths across the United States. Since 2017, ToxIC sites have reported multiple case data of such overdoses i...

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Collaboration within the Toxicology Investigators Consortium (ToxIC) ensures a national, multisite approach—boosting generalizability and helping track evolving overdose trends across diverse regions. #toxicology
www.acmt.net/fentanyl-ana...

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Clinically, this research will explore whether current naloxone dosing suffices against these potent synthetics. ED docs may need new protocols if higher or novel reversal agents prove necessary. #EDpreparedness

The Fentalog Study: A Subset of Nonfatal Suspected Opioid-Involved Overdoses with Toxicology Testing View substances detected in samples from patients experiencing a suspected opioid-involved overdose.

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From a public health lens: amid >108,000 overdose deaths in 2023 and 70 % opioid-related, this study aims to integrate real-time data into the CDC Fentalog Nonfatal OD dashboard—enabling region‑specific alerts and proactive intervention. #publichealthalert
www.cdc.gov/overdose-pre...

newsGP - GPs warned amid ‘worrying spike’ in nitazenes The ‘illicit and dangerous’ synthetic opioid has been found in fake pain medication, as GPs ramp up calls for pill testing to be expanded.

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The work sports strong media resonance: outlets are highlighting how fentanyl analogues and ultra-potent nitazenes—often missed by standard tests—are fueling overdose spikes. #medsky #fentanylepidemic
www1.racgp.org.au/newsgp/clini...