Gestational trophoblastic disease (GTD) classification. GTD encompasses a spectrum of benign and malignant lesions in the placenta. Benign lesions include atypical placental site nodule (APSN) and molar pregnancies [partial hydatidiform moles (PHMs) and complete hydatidiform moles (CHMs)]. Malignant gestational lesions, also known as gestational trophoblastic neoplasia (GTN), include invasive moles, choriocarcinoma (CC), placental site trophoblastic tumour (PSTT) and epithelioid trophoblastic tumour (ETT). Whereas all invasive moles follow a molar pregnancy, other cancers can be of molar or non-molar origin. The arrow indicates metastasis.

Gestational trophoblastic disease encompasses rare benign and malignant placental lesions. @alinanich.bsky.social @dagams.bsky.social & @mnileathlobhair.bsky.social examine #GTD from a molecular perspective, providing a unique framework for understanding this rare disease. doi.org/10.1242/dmm....

De-novo DNA Methylation of Bivalent Promoters Induces Gene Activation through PRC2 Displacement Promoter DNA methylation is a key epigenetic mark, commonly associated with gene silencing. However, we noticed that a positive association between promoter DNA methylation and expression is surprisin...

Really nice study from Marketa Tomkova's group @ndm.ox.ac.uk drawing link between DNAme, polycomb-antagonism and gene activation in cancer. A nice complement to our paper in ESCs (plus some rad epigenome editing experiments 😍). Congrats to all the authors! www.biorxiv.org/content/10.1...

Gestational trophoblastic disease: understanding the molecular mechanisms of placental tumours Summary: Gestational trophoblastic disease (GTD) encompasses rare benign and malignant placental lesions. This Review explores the potential genetic, epigenetic and microRNA drivers of GTD, highlighti...

New review paper out, in which we delve into the fascinating world of gestational trophoblastic disease. Never heard of it? Let me fill you in: (a 🧵) #epigenetics #cancer

Gestational trophoblastic disease: understanding the molecular mechanisms of placental tumours Summary: Gestational trophoblastic disease (GTD) encompasses rare benign and malignant placental lesions. This Review explores the potential genetic, epigenetic and microRNA drivers of GTD, highlighti...

Did you know the complete T2T sequence of a human genome was achieved by sequencing a cell line derived from a pre-cancerous placental lesion? 🧬🤰

📃 Our latest review explores the molecular mechanisms behind placental tumours and highlights why studying them matters:
doi.org/10.1242/dmm....

Are you into #rustlang and looking for (remote) #work? Want to help #cancer #research? We're planning to add some major features to a CLI app that require some serious software engineering skills. Understanding of stats a big +, genetics knowledge a bonus. Send me a DM! (Plz RT for reach) #rustjobs

Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome The placental DNA methylation landscape is unique, with widespread partially methylated domains (PMDs). The placental “methylome” is conserved across …

Excited to share our most recent work in Cell Stem Cell, led by @georgiaplea.bsky.social, characterising determinants of DNA methylation patterning in human trophoblast stem cells! A great collaboration with @vpglab.bsky.social.
tinyurl.com/93mchcd2

@loke-ctr.bsky.social @cam-repro.bsky.social