Relatedly - there really is *so much* to be optimistic about, regularly inspired by folks like Jett who will improve the way we care for people everywhere

The boy had just lost his dad to cancer. Jett Crowdis listened. — Harvard Gazette Harvard Medical School graduate found his calling in a connection forged while serving as a camp counselor.

Thinking about the way of the world, a chat ~25 years ago about a new camp for kids whose parents have cancer, and (soon-to-be) Dr. Jett Crowdis today

He shares his motivations in medicine, the link to Camp Kesem, and our science in @harvard.edu Gazette
news.harvard.edu/gazette/stor...

New horizons at the interface of artificial intelligence and translational cancer research Artificial intelligence (AI) is increasingly being utilized in cancer research as a computational strategy for analyzing multiomics datasets. Advances…

In this perspective, we examined the present and future interface of AI & translational cancer research for @cp-cancercell.bsky.social - led by the stellar Dr. Josephine Yates! @danafarber.bsky.social @broadinstitute.org www.sciencedirect.com/science/arti...

Thanks @danafarber.bsky.social @broadinstitute.org for the uniquely supportive + collaborative environments to pursue this work, NIH / NCI / PICI / Novartis + more for the research funding, & most importantly to the patients who continue to inspire by agreeing to these research programs...

Here's our latest - jointly with @rhaq1.bsky.social lab & co-lead by Drs. Schiantarelli, Benamar, Park et al - studying why some tumors stop responding to immunotherapy. This continues to be a tough puzzle to solve, but important for science & patients alike...

While on clinical service recently, I saw many children who were severely ill due to cancer, flu, and other causes. Sadly this move will mean that healthcare access for many children will be lost, as our institutions suffer from the loss of this critical support:
grants.nih.gov/grants/guide...

Thank you for the kind and thoughtful work!

Gillani Lab - Computational Pediatric Cancer Research Gillani Lab - Computational Pediatric Cancer Research

Tons of team science here, based on data from heroic kids + their families...

Also...check out Riaz's new lab (website): gillanilab.dana-farber.org

+ Ryan's original tweetorial on the preprint:
x.com/RyanLCollins...

+ @danafarbernews.bsky.social press release: www.dana-farber.org/newsroom/new...

Rare germline structural variants increase risk for pediatric solid tumors Pediatric solid tumors are a leading cause of childhood disease mortality. In this work, we examined germline structural variants (SVs) as risk factors for pediatric extracranial solid tumors using ge...

Here's our latest, led by Drs. Riaz Gillani & Ryan Collins - we studied a type of inherited genetic event (structural variants) + risk of developing certain cancers in kids:
@danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org @science.org

www.science.org/doi/10.1126/...

People sometimes make fun of science that sounds stupid and random.

Meanwhile, a study of lizard saliva turned into a peptide medication, which was turned into a diabetes medication, which was turned into a GLP1 weight loss drug, that just became the first therapy every approved for … sleep apnea

Our December knowledge base release is now out! With these two recent FDA approvals, we now have curated over 1,000 records🥳

Explore through our browser at moalmanac.org

Evolution of myeloid-mediated immunotherapy resistance in prostate cancer - Nature Single-cell profiling of human prostate cancer and studies in mouse models show that macrophages expressing SPP1 mediate immunotherapeutic resistance through adenosine pathway activation and repr...

Congrats to Larry, Aram et al on latest prostate cancer immunology effort, now out in @natureportfolio.bsky.social - fun collaboration + more to come! @danafarber.bsky.social @ucsfcancer.bsky.social www.nature.com/articles/s41...

Hello world! We're a paired knowledge base and algorithm for precision cancer medicine, based out of the @vanallenlab.bsky.social within @danafarber.bsky.social in #Boston #MA. You can learn more about us at moalmanac.org!

Distinguishing real from invented problems with the NIH How does the NIH work and where does it work well?

I wrote about the National Institutes of Health and the various serious and unserious proposals for NIH reform that have been floating around. It is important to understand how this agency actually functions and point criticism at the right problems. A short 🧵:

Great panel on AI in cancer research at the US Senate, led by Ned Sharpless and organized by Senators Rounds, Schumer, Heinrich, and Young - key engagement & thoughts from the organizers and other Senators, and a chance to share our exciting work at Dana-Farber and beyond!

Here, we built biologically interpretable computer vision models for H&E + mIF images to learn key tumor and immune microenvironmental states in kidney cancer that also inform immunotherapy response - congrats Drs. Nyman, Signoretti, Choueiri et al! www.cell.com/cell-reports...

Rarely are my LA childhood/living experiences helpful around here, but I just talked someone starting a lab in Children's Hospital LA out of "living by the beach and commuting to that part of Sunset"

Feels like I did something important, still shook by the potential catastrophe

hello world.