Last week, I had the opportunity to present my first poster at the @iacr.bsky.social in Belfast.

I found the PPI sessions particularly engaging. It was inspiring to learn from PPI experts and patients, and to have the chance to share my ideas in such a meaningful setting.
#IACR2025

What a glorious day! @lucygdornan.bsky.social and I had the privilege of showcasing origami microscopes #foldscopes to the school kids of Ireland at #BTYSTE with the @ec.europa.eu

Feeling like I achieved nothing this year after graduation but then I remembered…

Jokes aside I did learn how to western blot so surely that is equivalent 😂 #phdsky

Trying to define a research gap as a 1st yr PhD student 🫠
#phdsky

Me please!

This image portrays a graphical abstract for the Cell Genomics Preview article by Dornan & Simpson (2024). This graphical abstract summarises the workflow and key findings of a research paper by Lacoste, Haghighi and colleagues in the most recent edition of Cell. In summary, 3,448 variants from a collection of 1,269 genes were GFP-tagged and transfected into cells. Using high-content screening microscopy, the researchers identified that improper localisation of proteins encoded by the gene variants accounted for a huge 16% of all pathogenic variants studied. Upon further investigation, they also found that mislocalisation correlated with disease severity, and that mislocalised proteins also tended to be unstable and misfolded. This work has highlighted the importance of correct protein localisation, and developed a highly effective and useful screening system for the identification of mislocalised proteins which has huge implications for alternative and innovative drug discovery methods.

🧪 Excited to see this go live today! We wrote a Preview article exploring the stunning work by Lacoste, Haghighi and colleagues @drannecarpenter.bsky.social @shantanuxsingh.bsky.social @mike_tilapia in the latest edition of Cell.

doi.org/10.1016/j.xg...