Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis Nature Genetics - This study uses somatic mutations as a natural barcoding system to retrospectively and prospectively trace the fate of hematopoietic stem cells across all major blood cell...

A new study by @tetsuichi.bsky.social et al published in @natgenet.nature.com shows that human blood #stemcells have stable, intrinsic lineage biases. Some replenish all blood cell types, others only a subset. These patterns persist over decades and after transplantation 🧪 #bloodcancer rdcu.be/ePlJW

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