Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity Why the link between immune infiltration and tumor control varies so strongly across tissues remains unresolved. We propose the “immunometabolic gatekeeping” framework, whereby tissue-intrinsic metabo...

🆕Paper from Naomi van den Berg (@naomiirisvdberg.bsky.social) in Cancer Cell proposes the "immunometabolic gatekeeping" framework to explain how tissue metabolism conditions tumour immunity

@crick.ac.uk @cruk-mi.bsky.social @uofgcancersciences.bsky.social
@cp-cancercell.bsky.social

🚨Don't miss out! Early bird registration for #BICC2026 closes 1 April (10am BST)

Join global leaders in cancer immunology in Glasgow this June
📍 @cruk-si.bsky.social, Glasgow | 📅 22-25 June

#CancerResearch #Immunology

👇Register now👇

📣Register now for the Beatson International Cancer Conference 2026 ‘From Tumour Genesis to Metastasis: an immune perspective’

📅22-25 June 2026
📍CRUK Scotland Institute, Glasgow
🎟️Early Bird registration closes on 1 April
🔗 www.beatsonconference.org

#BICC2026 #CancerResearch #Immunology

Our Best Models Working Group can offer advice on the use of a range of model systems.

The next in our series of #MeetTheExpert posts features Laura Greaves, whose group investigates the role of age-related mitochondrial DNA mutations in cancer biology

nmgn.mrc.ukri.org/working-grou...

MAPK-driven epithelial cell plasticity underlies CRC therapeutic resistance | National Mouse Genetics Network (White et al., Cancer Research UK Scotland Institute and collaborators across the MRC National Mouse Genetics Network – Cancer Cluster) Colorectal cancer (CRC) is a genetically complex disease, yet re...

MAPK-driven epithelial cell plasticity underlies colorectal cancer therapeutic resistance:

Members of our Cancer Cluster contributed to a recent paper that provides insight into resistance to therapy and suggests strategies that may improve therapeutic efficacy

nmgn.mrc.ukri.org/news/mapk-dr...

CBL ubiquitin ligase targets translation as a degrader E3 Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules that recruit an ubiquitin ligase (E3) and a neo-substrate into a ternary complex, enabling selective protein degradation. Desp...

My first-author paper is out in @chemicalscience.rsc.org from my time in Professor Danny Huang’s laboratory @cruk-si.bsky.social. We showed that CBL can be used as a degrader E3 to target the “undruggable” eIF4E.
pubs.rsc.org/en/content/a...

We are delighted to announce that @mitosrus.bsky.social from @cruk-si.bsky.social @glasgow.ac.uk has been awarded the 2026 Hooke Medal

You can read about Stephen's work on mitochondria, cell death and cancer here:

bscb.org/hooke-medal-...

Scientists discover potential new treatment to tackle cancer The research focused on the genetic faults that allow the disease to hijack a signalling system in the body.

📣Research from Owen Sansom's group @cruk-si.bsky.social has suggested a new way to tackle liver and bowel cancers

📖Read the full paper here: www.nature.com/articles/s41...

Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation - Nature Genetics Npm1 promotes tumor formation via attenuating the integrated stress response and p53 activation in mouse WNT-driven intestinal and liver tumorigenesis.

🆕Paper in @natgenet.nature.com from Georgios Kanellos in Owen Sansom's lab: Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation www.nature.com/articles/s41...

Scotland Tonight Dr Susanti and Dr Johan Vande Voorde on early on set bowel cancer. YouTube video by Fiona MacLeod

Bowel cancer is increasingly diagnosed in young people in Scotland - but what are we doing? Hear about our heroes in lab coats who are seeking answers, Dr Santi Susanti and Dr Johan Vande Voorde👇🥼
@cruk-si.bsky.social @johanvandevoorde.bsky.social @uofgnews.bsky.social
youtu.be/if0VzNmlnx8?...

Read the newly published impact report from the SPECIFICANCER team that reshaped our understanding of tissue specificity.

Thanks to our co-funders, @themarkfdn.bsky.social, for supporting the #CancerGrandChallenges team and global science.

🔗 lnkd.in/eDrQ9guu

Liver lobule zone molecular characteristics dictate susceptibility to WNT-driven liver cancer

📷 Alexander Raven et al @cruk-si.bsky.social in @nature.com

➡️ bpod.org.uk/archive/2025...

The new paper from SPECIFICANCER, published in
@natureportfolio.nature.com reveals that it’s not just the mutation that matters — it’s where in the liver that mutation appears.

Congratulations to the team (co-funded by
@themarkfdn.bsky.social). 👉 Read more: lnkd.in/eTVh9YY6

⌛Just one week left to submit your applications for the Black Leaders in Cancer PhD programme in Scotland!

Less than 3 weeks left to submit an abstract to the PREDICT-Meso International Conference 2026 in Glasgow

Categories:
CLINICAL STUDIES&PATIENT CARE
TARGETS
MODELS&THERAPIES
RISK&RESPONSE

Submit abstracts online eventsforce.net/predict_meso... by 30 Nov 2025 #Mesothelioma #MesotheliomaConference

Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?

rdcu.be/eN1jm

@uofgcancersciences.bsky.social @uoe-igc.bsky.social

📢 Applications for the Black Leaders in Cancer PhD programme in Scotland are now open!

The programme offers a unique opportunity for students from Black heritage backgrounds to pursue a fully funded 4-year PhD.

👉Apply by 24 November 2025: www.crukscotlandcentre.ac.uk/training/phd-studentships

🩷Thanks to everyone from @cruk-si.bsky.social and @uofgcancersciences.bsky.social who took part in our #WearItPink day today raising money for @breastcancernow.bsky.social 🩷

Two scientists in white coats and safety specs smile in front of a large machine labelled 'keNMR'

👏 Congrats to Ridvan Nepravishta and Kenneth Cameron at @cruk-si.bsky.social on their paper in #JACS:

Fast and reliable NMR-based fragment scoring for drug discovery bit.ly/43LfgYa

#OnMyHorizon
@pubs.acs.org @csic.es @edinburgh-uni.bsky.social @rnepravishta.bsky.social @angulo-lab.bsky.social

Biosciences Student Placement (Lab based) Cancer Research Horizons Biosciences Student Placement (Lab based) £23,000 plus benefits Directorate: Research & Innovation Contract: Fixed Term Contract 52 weeks Hours: Full time 35 hours per wee...

Undergraduates, we are recruiting! Come and join us at the @cruk-si.bsky.social in Glasgow for your industrial placement year. Start date September 2026. Great lab, great people, great city. Take a look!

cancerresearchuk.wd3.myworkdayjobs.com/en-US/Extern...

Are you interested in becoming a clinical academic leader in a cancer-focused discipline? @edinburgh-uni.bsky.social, @uofglasgow.bsky.social, @cruk-si.bsky.social & Cancer Research UK Scotland Centre are seeking four ambitious people for the TRACC+ Programme August 2026 intake 👉 edin.ac/4nGK5oC

🎉Good news! The deadline for abstract submissions has been extended!

You now have until Friday 3 October to submit your abstract for the @cruk-si.bsky.social Workshop: 'Lessons from the Microbes Within Us; Developing Next Generation Immunotherapeutics'

Last session in full swing! #OrganoidsAreUs2025

Our first session of today's #OrganoidsAreUs2025 is dedicated to organoid models in cancer research.
We go with
✨ Vincenzo Corbo
✨ Ben Dwyer
✨ Maximilian Reichert
✨ Chiara Braconi

Another packed session for a critical and fast-developing field!

Group Leader Recruitment at the Cancer Research UK Manchester Institute YouTube video by CRUK Manchester Institute

Exciting news - we are recruiting new Group Leaders! 🥼

We are seeking to appoint exceptional early-career scientists & clinician scientists as #GroupLeaders to develop bold, innovative, high-impact #CancerResearch programmes

Full details on our website: www.cruk.manchester.ac.uk/career/new-g...

Second session on #StemCells #regeneration and #cancer. We start with
🧪 Phil Jones from the @sangerinstitute.bsky.social
🧪 Followed by Suet Yu Leung from Hong Kong Uni and
🧪 Eleanor Earp from @edinburghuni.bsky.social ,
✨ First keynote lecture by Helmuth Gehart from @ethz.ch
#OrganoidsAreUs2025

A day dedicated to #StemCells #regeneration and #cancer. 1st session sponsored by TECAN with Nick Barker from A*STAR, Amian Barai from @univ-amu.fr and our first Tony Burgess Orator, Vivian Li from @crick.ac.uk, providing a fascinating insight into this fast-developing area #OrganoidsAreUs2025

Opening session sponsored by @stemcell.com and OLS with a welcome from Director Owen Sansom @cruk-si.bsky.social and Elizabeth Vincan @unimelb.bsky.social . Our plenary speaker Prof Hans Clevers from @utrechtuniversity.bsky.social talks about human epithelial organoids. #OrganoidsAreUs2025