A potential trauma-related astrogliopathy?

Subpial tau astrogliopathy is frequently seen alongside CTE lesions and we also see it in our repeated head impact cases that don't have CTE. It's exciting to see new data exploring this.

If you're at #ADPD2025 come see us at poster 564 (Chelsie) and 587 (me)

Billy Guyton's legacy: NZ scientists make significant CTE breakthrough Scientists studying the brains of rugby players have made a breakthrough that could potentially allow CTE to be diagnosed in living players.

Our local news also profiled this work. Check it out: www.1news.co.nz/2025/03/11/b...

Huge thank you to our collaborators who supplied the CTE tissue for this study, and congratulations to my PhD student Chelsie Ostermann who was the lead author on this paper.

Our labelling shows that markers for astrocyte reactivity were most concentrated around the lesion vessels.

We investigated markers of microglial and astrocyte reactivity, different tau species, ubiquitination, neurofilaments, neurons and blood vessels in lesion and non-lesion areas of frontal cortex from CTE cases.

Tau lesions in chronic traumatic encephalopathy (CTE) are also sites of concentrated glial reactivity.

In our recent paper published in Acta Neuropathological we used multiplex immunohistochemistry to explore the microenvironment of these lesions

link.springer.com/article/10.1...

Congratulations also to Stanley Cardon for winning the highly commended award for the Light Microscopy category. His image from his honours project shows markers of reactive astrocytes in the Alzheimer's disease frontal cortex.

Congratulations to Meagan Chamberlain for winning 🎉 the Light Microscopy category prize for her image showing different types of tau in the Alzheimer's disease hippocampus. This image is from Meagan's masters project exploring the composition of tau tangles in AD and frontotemporal dementia.

My team produced some truly stunning images of the brain this year using multiplexed immunohistochemistry. These two won awards at our Faculty of Medical & Health Sciences image competition

#FluorescenceFriday

Method of the Year 2024: spatial proteomics - Nature Methods Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

New platform, new me.
Hi I'm Helen! I study the neuropathology of tauopathies and
I enjoy labelling brain tissue sections with as many antibodies as I can.

Enjoy one of my favourite multiplex IHC images of a cortical brainbow 🌈

#microscopy #multiplexIHC #neuropathology #tau #glia