Sounds like what we need is something that makes it easier to generate quantitative, interpretable metrics that describe observable biological differences in tissue, without being a black box and requiring unreasonable amounts of training data...

www.muspan.co.uk

doi.org/10.1101/2024...

Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state https://www.biorxiv.org/content/10.1101/2024.11.28.625928v1 In colorectal cancer (CRC), tumours classifier as consensus molecular subtype 4 (CMS4) have the wors

Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state www.biorxiv.org/content/10.1101/2024.11....

Massive congrats to Shania, Svetlana & Noha (not on Bsky) identifying the mechanistic and phenotype cascades underpinning the anti-metastatic response triggered by viral mimicry

TLDR; aggressive CMS4 tumours can be reprogrammed towards less aggressive CMS1

biorxiv.org/content/10.1...

thread 👇

Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data - Scientific Reports Scientific Reports - Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data

Massive congrats Courtney and @sidmall.bsky.social
on their dualGSEA publication nature.com/articles/s41...

dualGSEA blends pair-wise and single sample GSEA approaches alongside a range of visual outputs, making biological interpretation of results much easier.

👀🧵👇& then Repost please!

1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces.
biorxiv.org/content/10.1101/2024.11.06.622266v1

We ask students to write a research proposal, but we should also teach them about how the project will likely actually unfold.

Hello, could I be added too, please. Thanks!

Hello 👋, I would be keen to join too, please. Thank you!

Hello, would love to be included as well, please! Thank you.