Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS 🧬 🧪

To learn about

➡️ Transposable elements and the human brain ⬅️
by ⭐ professor Vivien Horvath⭐ from @umeauniversitet.bsky.social

@kawresearch.bsky.social @scilifelab.se @remeseiro-lab.bsky.social
REGISTER NOW!
www.trippus.net/summerschool...

Microscopic picture of hair follicles embedded in mouse skin with circumferential nerve endings wrapped around them.

Imaging cutaneous nerve endings never gets old! 🟣 DAPI 🟢 tdTomato-labelled circumferential nerve endings around hair follicles in mouse skin. #FluorescenceFriday

This year’s ESCAN ECR award 😱🫂 Thank you so much 🙏🏼 Congrats also to Rita, can’t wait to see all ESCAN colleagues and friends in Rome this year. 🤍

@escaneu.bsky.social @liu.se

This looks unreal!

I'd finally have the mental capacity to post shit

Just out our recent research paper.
Dive into the details here 👇🏼

Fresh pre-print: our all-human, innervated & vascularized oral cancer-on-chip, all done with fully defined extracellular matrices with controlled enrichment and degradability! 🔥

www.biorxiv.org/content/10.6...

Cartoon transparent human with skeleton showing, red glowing points on joints to indicate pain

Do YOU live with joint pain?

Do YOU experience poor pain management?

Have you got 2-minutes to tell pain researchers about it?

If yes 👉 forms.gle/7NTwma2gnVN1...

We hope to gain insight into lived experience for those with joint pain & involve people in our #PainResearch 😃

Neat!

You are correct, its works in this context too though. I brought it up because its so similar to the Lithuanian saying

The Polish, slightly aggressive version of this is "nie interesuj sie bo kociej mordy dostaniesz", which means "don't get curious or you will get a cat's face"

Though if you agree on not pushing the matter you may say "nie moj cyrk, nie moje malpy" ("not my circus, not my monkeys")

Congratulations Alex! Good luck with the new challenge 😎

Check out the new preprint for the lab. Bridging functional and transcriptional identity of nociceptors reveals organizational logic of the system that allows for feeling many different types of pain! #PainResearch

Yes, we'd sometimes have bleedthrough in red and green channels from opal 690 while using standard RNAscope protocol. Only from cells with very high signal though.

Inspiring talks & discussion on how to move forward with neuronal classification in the age of multiomic integrations on today's dual perspective at #SfN25. Super important stuff if we want to make real clinical impact. Thanks @vabraira.bsky.social, @tedpricethepainguy.bsky.social and Jeremy Miller!

Exactly when i present my poster 🥲 bet its gonna be a great session, enjoy!

I'm with you on this Micah.

A question out of curiosity though: is the one-problem-sausage-made approach ever a valid strategy when giving a job talk?

Congrats! 🎉

Brightly labelled pyramidal cells in the mouse retrosplenial cortex. Blood vessels are visible of various thicknesses in darker colours.

#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience!

Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia.

Sharing appreciated, and happy #FluorescenceFriday !

That's one way to put it ;)

You gotta come back for a Bäversnaps chaser.

@psalmotoxin.bsky.social mesmerized the Linköping Somatosensory crowd with his great research! As photographic evidence suggests, Marcin was euphoric, so was I. Thanks for visiting!

An example of what we in the NIH Intramural program can accomplish. Excited to share our latest paper in close collaboration with Nick Ryba's group. We examined how inflammation transforms representation in somatosensory neurons to cause pain. Lots of surprises here: www.nature.com/articles/s41...

Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord - Nature Neuroscience Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...

How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study.

www.nature.com/articles/s41...

Our first release in the attempt to build the Transcription Factor Binding (TFB)-OMICS during #DevBio is now out in Development @dev-journal.bsky.social
doi.org/10.1242/dev....
👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue

Strong agree. The article's title should've been "How to write a quick, shitty review that will frustrate the authors and bring nothing good to the table. Now with AI!"

Finally, we managed to take a lab picture

I really think one of the best things about science is the people you meet along the way. Thanks @mbrodzki.bsky.social,Gabriela, Leandro, Christoffer and Felipe!Especially thanks to @szczotml.bsky.social and Ilona,I really enjoyed all our discussions!
Now, I'm very excited about what's coming next!

Chatty cortical neurons #FluorescenceFriday

Engineered commensals for targeted nose-to-brain drug delivery Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic mo...

www.cell.com/cell/fulltex...

This is so wacky. I love it.