Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states: Cell www.cell.com/cell/fulltex...

SARM1 executes neuronal parthanatos and promotes excitotoxic cell death
www.cell.com/neuron/fullt...

Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca2+-mediated increases in astrocytic cholesterol
www.nature.com/articles/s41...

Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin @cp-immunity.bsky.social www.cell.com/immunity/ful...

Neuron-derived mitochondrial DNA (mtDNA) activates microglia via the Z-DNA binding protein 1 (ZBP1)-mediated pathway in mild traumatic brain injury
www.pnas.org/doi/abs/10.1...

Evolving brain-immunity: From Ramón y Cajal’s mysterious butterflies to a garden sustained by immune cells as their nectar Over the last three decades, dogma-breaking studies have refuted the brain’s assumed immune isolation. Echoing Ramón y Cajal metaphor of neurons as “butterflies,” Schwartz proposes viewing the brain a...

Evolving brain-immunity: From Ramón y Cajal’s mysterious butterflies to a garden sustained by immune cells as their nectar: www.cell.com/neuron/fullt... 🦋💐 @cp-neuron.bsky.social

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration - Nature Neuroscience ALS/FTD-linked mutations in UBQLN2, a protein quality control factor, impair degradation of enzymes essential for mitochondrial lipid catabolism, leading to metabolic dysfunction and neurodegeneration...

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration
www.nature.com/articles/s41...

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition @cp-neuron.bsky.social www.cell.com/neuron/fullt...

The Genotoxic Stress Sensor ZBP1 Drives Tauopathy and Neurodegeneration
www.mdpi.com/2073-4409/15...

A transcriptomic microglia taxonomy across mouse and human pathologies www.nature.com/articles/s41...

Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures: @cellpress.bsky.social www.cell.com/cell/fulltex...

2027 Neuroimmune Gordon Research Conference - Jan 24-29, 2027👇 www.grc.org/neuroimmune-...

From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus Chronic pain often evolves into depression and anxiety, yet mechanisms linking sensory distress to affective dysfunction remain unclear. Integrating human neuroimaging from the UK Biobank with a roden...

From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus www.science.org/doi/10.1126/...

A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation Psychological stress is believed to exacerbate dermatitis, yet the neurobiological mechanisms linking stress to immune processes remain elusive. We identified a subset of prodynorphin-positive (Pdyn+)...

A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation www.science.org/doi/10.1126/...

Brain’s protective barrier stays leaky for years after playing contact sports Damage to the blood-brain barrier is linked to immune changes and cognitive decline.

Brain’s protective barrier stays leaky for years after playing contact sports www.nature.com/articles/d41...

Brain’s protective barrier stays leaky for years after playing contact sports Damage to the blood-brain barrier is linked to immune changes and cognitive decline.

Brain’s protective barrier stays leaky for years after playing contact sports www.nature.com/articles/d41...

6-Hydroxydopamine promotes antitumor immunity through macrophage remodeling beyond sympathetic ablation: Neuron www.cell.com/neuron/fullt...

Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation
www.nature.com/articles/s41...

Persistent microglial activation following neonatal CMV infection mediates neurodegeneration www.science.org/doi/10.1126/...

Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis
www.nature.com/articles/s41...

Resident tissue macrophages maintain intraocular pressure homeostasis. @cp-immunity.bsky.social www.cell.com/immunity/ful...

Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs: @cellpress.bsky.social www.cell.com/cell/fulltex...

JCI - Disruption of CSF-1 receptor-mediated metal ion homeostasis in the murine brain promotes neurodegenerative disease www.jci.org/articles/vie...

New work from the lab on how sickness reduces appetite. Turns out, it’s complicated :)

We focused on a single inflammatory cytokine, IL-1b, and even that reduces appetite via multiple mechanism.

Thanks to Nik Hayes for leading and sticking with this project and to everyone else who contributed!

Central neurons encode interleukin-1β signals and mediate stress-induced inflammation url: rupress.org/jem/article/...

Immunity in Alzheimer’s disease: From mechanisms to therapies @cp-immunity.bsky.social www.cell.com/immunity/ful...

JCI - The hidden world of nanoplastics colliding with neurodegenerative diseases www.jci.org/articles/vie...
www.jci.org/assets/40885...

Endogenous retrovirus-derived RNA-DNA hybrids induce microglial synaptic pruning in autism models @cp-neuron.bsky.social www.cell.com/neuron/fullt...