Join us for the FASEB Science Research conference on TGF-β Family in Development and Disease!
Awards Abstract Submission Deadline: April 15, 2026.
@faseborg.bsky.social @mythreye.bsky.social
Activin A secretion by muscle-repairing macrophages induces heterotopic ossification in mice @jci.org
www.jci.org/articles/vie...
Excited to announce the opening of the applications for the Master in Biomedical Research.
An international, hands-on programme for students to think like scientists, work in real labs, and prepare for PhD training or R&D careers, in Lisbon. GIMM Institute
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Registration is open 😀!
Make a note of these dates:
Awards Abstract Submission Deadline: April 15, 2026
Regular Abstract Submission Deadline: May 31, 2026
Early Registration Deadline: June 14, 2026
events.faseb.org/event/TGF-B/...
Check out the line-up for the @faseborg.bsky.social Science Research Conference on TGF-β Family in Development and Disease 👇
events.faseb.org/event/TGF-B/...
Check out the global speaker line up. several travel awards and slots
for short talks open. Don’t miss this summer @faseborg.bsky.social events.faseb.org/event/TGF-B/...
Decoding the Mechanism of Action of a Parasite TGFβAntagonist Inspires the Creation of Cell-type-specific TGFβ Modulators www.biorxiv.org/content/10.64898/2026.02...
Cow Tools!
We have lived alongside cows for nearly 10,000 years.
We breed them and exploit them
It is now, only now, that we have discovered THEY CAN USE TOOLS
Here I describe our study
(paper) www.sciencedirect.com/science/arti... in @currentbiology.bsky.social
with @auersperga.bsky.social
😂
Hyperactive BMP and Mechanosignaling Remodel Chromatin to Drive Aberrant Osteogenesis in FOP www.biorxiv.org/content/10.64898/2026.01...
Discovery and Characterization of Zilurgisertib, a Potent and Selective Inhibitor of Activin Receptor-like Kinase‑2(ALK2) for the Treatment of Fibrodysplasia Ossificans Progressiva. T Ullrichet al. ACSMed.Chem. Lett. 31Oct 2025 shorturl.at/UCzDT …mouse model …start clinical trial
🚨 New paper out!
A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development
Here is the full paper: rdcu.be/eSWEs
🧵 A twittorial:
THREAD
Researchers report knockdown of Activin receptor-like kinase 5 (ALK5) & Mothers against decapentaplegic homolog 2 (SMAD2) - 2 genes of the TGFb pathway, protected dopaminergic neurons from a-Synuclein-induced toxicity; ⬆️TGFb signaling exacerbated a-Synuclein toxicity
www.nature.com/articles/s41...
C'mon guys. Cells show blebbing and death was inhibited by caspase inhibitors and had mitochondrial permeabilization.
In my alternate universe, this is apoptosis 🙄
🧬 Kinase Inhibitors can do more than block their targets!
A study by @cemm.oeaw.ac.at-@aithyra.bsky.social and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.
Out in @nature.com
➡️ bit.ly/43SD9xj
Many congratulations, Emma! I had fun discussing receptors and signalling with you. Good luck with future projects ☺️!
European Respiratory Journal: The activin signalling inhibitor sotatercept may transform PAH therapy by targeting pulmonary vascular remodelling, but unique safety risks demand careful monitoring https://bit.ly/3UBsPVj
BMP9 enhances osteogenic differentiation in rheumatoid arthritis. BMP9 is down-regulated in synovial tissue of RA patients. In arthritis mice model BMP9 enhances osteogenic differentiation of synovial cells. Han Zhang et al. J Transl Med 2025 Feb 28 tinyurl.com/y65xbekk
BMP9 regulates the endothelial secretome to drive pulmonary hypertension www.biorxiv.org/content/10.1101/2025.08....
Our preprint is out! We induced apoptosis in myeloma cells with BMP9 and did a whole genome KO screen to find regulators of apoptosis (and BMP-SMAD signaling). ID3 induced by SMAD activity inhibited TCF3 and induced apoptosis.
This was the main work in Clara Andersson-Rusch's PhD. Have a look! 👇
Album cover Skunk Anansie Stoosh
Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...
#Reproducibility
Excited to share our new manuscript, now published in Blood! BCMA #CART show impressive responses for #myeloma, but pts with high-risk cytogenetics relapse more quickly and are in urgent need of new therapies. Thread👇 (1/10) ashpublications.org/blood/articl...
Nice work! Temporal patterns of genomic evolution in multiple myeloma showing importance of timing of events for progression and prognosis. #myeloma #multiplemyeloma #hemesky
www.nature.com/articles/s41...
GCK inhibition induces IKZF1 degradation through a CRBN-independent mechanism in MM. buff.ly/B79qqYd #hemesky
Flyer for a conference
📣 Save the date 📣
The next FASEB Science Research Conference on TGF-β Family in Development and Disease will take place:
July 26-30, 2026 in Porto, Portugal!
@faseborg.bsky.social
With Mythreye Karthikeyan @mythreye.bsky.social, Rosemary Akhurst and Andrew Hinck
web.cvent.com/event/af5f6d...
Elskar når folk som ikkje anar noko om landbruk skal romantisere denne livsstilen, og så lage tv av at dei ikkje er førebudd på det betyr å vere bonde. Då blir det rør. Heggdal er god til å rydde opp.
Vi må ta kampen mot brøl-apene som maksimerer utnyttelsen av urimelige konflikter, gjennom sort-hull effektene på vår oppmerksomhet. Men hvordan? Her er iallefall bilde av rett person @froyasjursaether.bsky.social
Ever wondered what happens when therapeutic antibodies bind to cancer cells? In our latest study, we used multiplexed 3D-RESI to directly visualize how anti-CD20 antibodies interact with their receptors, revealing their precise arrangement at single-protein resolution. (1/6)
