Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential - npj Biomedical Innovations npj Biomedical Innovations - Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential

Dr. @kolade-adebowale.bsky.social's team reviews macrophage mechanobiology and the potential of engineered macrophages, using genetic or non-genetic “Trojan horse” strategies, to deliver therapies and reshape the immunosuppressive TME.

👣 Follow the link: https://go.nature.com/4rKWHNP

Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential - npj Biomedical Innovations npj Biomedical Innovations - Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential

I’m pleased to share our lab’s first paper (a review), highlighting new insights into macrophages, their mechanobiology, and cancer therapeutic potential through both genetic and non-genetic approaches. @jacobsschool.bsky.social.

www.nature.com/articles/s44...

Glassy adhesion dynamics govern transitions between sub-diffusive and super-diffusive cancer cell migration on viscoelastic substrates - Nature Communications This study introduces glassy adhesion dynamics within a motor–clutch framework, revealing the mechanism by which cellular and extracellular timescales interplay and govern anomalous cancer cell migrat...

New publication alert! We use theory and experiment to demonstrate that glassy adhesion dynamics can predict anomalous migration on viscoelastic substrates. Grateful to have worked with Vivek Sharma, Ze Gong, Ovijit Chaudhuri, and Vivek B Shenoy 🙏 !

www.nature.com/articles/s41...

Excited to have delivered a guest lecture to students in our "Introduction to Bioengineering" course about some of the exciting and cutting-edge research in studying cancer-immune interactions. Thx, Prof. Reem Khojah, for the invitation (and action shots!) @ucsandiego.bsky.social.

We had our inaugural "4th floor Friendsgiving". Many thanks to Drs. Vira Kravets and Erika Cyphert for helping organize. Gotta love the Snoopy with a scarf background pic. Looking forward to growing our community of Bioengineers on the 4th floor (UC San Diego Bioengineering). 😎

$1 Million from Prebys Foundation Supports Pivot Grants to Drive Medical Research at UC San Diego The UC San Diego School of Medicine announced the inaugural recipients of its pivot grant program, an initiative made possible by a $1 million gift from Prebys Foundation to help protect San Diego’s b...

Thank you, Prebys Foundation, for supporting our work to understand how physical cues regulate macrophage and T cell responses in diseases like cancer. These insights can help us maximize the clinical impact of macrophage- or T cell-targeting therapies.
today.ucsd.edu/story/1-mill...

First Kolade Lab social outing (mini-golf ⛳️then dinner). Starting a lab is tough, but this amazing and fearless crew has made it so much easier over the past four months!

Thanks for posting about this 🙏🏾.

Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices | PNAS Circulating monocytes are recruited to the tumor microenvironment, where they can differentiate into macrophages that mediate tumor progression. To...

New paper! We find that fast matrix stress relaxation potentiates human monocyte 3D migration by generating protrusive forces and is dependent on the Cdc42-WASp axis. Thanks to our amazing collaborators👏! #viscoelasticity #mechanobiology @stanford-chemh.bsky.social

www.pnas.org/doi/10.1073/...

Mechanoregulation of lymphocyte cytotoxicity - Nature Reviews Immunology Cytotoxic T lymphocytes and natural killer cells destroy target cells using a mechanically active cytolytic immune synapse. This Review examines the various ways in which mechanical forces contribute ...

Recent review from The Morgan Huse Laboratory @ Memorial Sloan Kettering Cancer Center on "Mechanoregulation of lymphocyte cytotoxicity".

www.nature.com/articles/s41...

Our confocal got installed today! Gotta celebrate the wins. #BabyPI

Great catching up with our seminar speaker, Professor Darrell Irvine, and our colleagues from @UCSD's Jacobs School of Engineering.

We had a great time celebrating our one-month anniversary at UC San Diego Bioengineering with Dr. Vira Kravets's and Dr. Xiaohua Huang's labs, and Isgard Hueck. Special thanks to Dr. Vira Kravets lab for the amazing lab swag including a gift of a very studious cytotoxic T cell mascot (to be named!)

Exciting to see. Congratulations Rayyan and @brianaguado.bsky.social 👏🏿!

Thanks @phosphotig.bsky.social 👏! Right back at ya though. I am excited to follow your lab's work, and the exciting discoveries from you and your team @unc-bcbp.bsky.social!

Thanks @carolynbertozzi.bskyverified.social 👏! It is difficult to overstate the impact the @stanford-chemh.bsky.social CBI T32 had in training me in cross-disciplinary research and how that training continues to impact my research today. Thanks for the T32 post @jeremymberg.bsky.social.

Our lab doors opened on Monday @ucsdbe and we had lab lunch today! Very excited to have three grad students (Sophia, Ruturaj, and Xiaoya) and one undergrad (Josie) rotating. More of our scientific adventures to come😎!

Thanks Professor @anamaporras.bsky.social for delivering an engaging and stimulating talk! And An’s gelato did not disappoint!

Great catching up with my friend Prof. Toshiro Hara
from the University of Michigan Medicine and meeting Prof. Gerald Pao from the Okinawa Institute of Science and Technology (OIST) in San Diego.

In Memory of Andy Acrivos: CEMS Alum and Titan of Chemical Engineering Andreas (Andy) Acrivos passed away on February 17, 2025. Born in Greece in 1928, Prof. Acrivos arrived at Minnesota in 1950 following undergraduate studies at Syracuse University, becoming the  second...

In Memory of Andy Acrivos: University of Minnesota Alumnus and Titan of Chemical Engineering
cse.umn.edu/cems/news/me...

Thanks for the shoutout @blackinbme.bsky.social 🙏🏾!

@ucsandiego.bsky.social newest faculty member @kolade-adebowale.bsky.social sharing the culmination of his work and the vision of his lab #Afrobiotech

Explore this Starter Pack 🚀 with researchers, engineers, and enthusiasts passionate about #Biopolymers & #Biomaterials in nanoscience, sustainable materials, 3D bioprinting, regenerative medicine, and related fields.

🔗 DM/comment/tag to self-nominate or suggest others!

go.bsky.app/HCEddD2

Thanks so much @peterwich.bsky.social! Looking forward to the cool and exciting science 😎!

Thanks for starting this. Can I be added?✋

Very cool. Thanks for sharing!

Asteroid fragments upend theory of how life on Earth bloomed Samples from Bennu contain the chemical building blocks of life — but with a twist.

"Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise… nearly equal amounts of these structures and their ‘right-handed’, mirror-image forms."

Excited for the 2025 GRS/C Physical Science of Cancer kick-off in Pomona, CA soon with all the exciting science. Thanks to GRC Co-Chairs Kandice Tanner, Erik Sahai, and my GRS Co-Chair Gabrielle Grifno. Please tag your favorite moments with #POC_GRC_2025! Safe travels everyone.

Because you have nothing else to worry about, remember that, starting May 25, you will have to use SciENcv to generate your biosketch for any NIH application.

LINK here: www.ncbi.nlm.nih.gov/sciencv/

Applications are still being accepted for the Summer 2025 REU, UCSD-BRIDGE @ UC San Diego! The deadline is February 11. More details below 👇.