Last week I successfully passed my viva 🎓! It was a pleasure to discuss the work with @aidarodrigo.bsky.social, @bayraktarlab.bsky.social and @willmacnair.bsky.social, and to celebrate with the lab @annawilliamslab.bsky.social (thanks for this amazing single-cell hat!)

New preprint! Our workflow for processing single cell and nuclei data, called 🎉 scprocess 🎉 We have been working on it for ~18 months now, over which time we have processed at least 2k samples with it, so it has had a decent amount of testing.

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social

Huge team effort, with immense contributions by friends from nearby and around the globe.

www.science.org/doi/10.1126/...

And importantly thanks to all the patients involved and the people who made this work possible: first of all my PhD supervisors, Fiona and Dan, @tedpricethepainguy.bsky.social for hosting me in his lab and @dianatavf.bsky.social, Ish and Natalie for the huge help and support!!

Thanks to Sebastian Strauss and Martin Lotze for the nice commentary: journals.lww.com/pain/fulltex...

Very happy to share that the work from my PhD is in press at PAIN 😊

The lab went to our institute Halloween party as research models- spot yeast, human, E.coli, naked mole rat, axolotl, fusing organoid, frog, drosophila, excitatory neuron and oligodendrocyte!!!

Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD
Thanks to Nina and all of the team!

This work is finally online as in-press preview!

JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

Are you interested in omics approaches to pain and projection neurons? Why not join us? We’ve got a post-doc position available. Happy to discuss further with anyone who is interested. www.jobs.gla.ac.uk/job/research...
#neuroskyence #neurosci #PainResearch

BBC Inside Science - How vulnerable is our power supply? - BBC Sounds Massive power cuts brought parts of Spain, Portugal and France to a standstill this week.

EDINBURGH AXOLOTLS!

Super-excited to hear my wonderful colleague @aidarodrigo.bsky.social on BBC Radio 4 talking about the axototl colony she has established in our institute @edinuni-irr.bsky.social 😃

Available on BBC sounds: Aida's section starts at 23.37

www.bbc.co.uk/sounds/play/...

It’s international woman’s day! Well we have a lot of amazing women in our group to celebrate from our fierce leader @annawilliamslab.bsky.social to our PhD students, postdocs, bioinformaticians, and everyone in between💪🏻 Thank you ladies for being amazing scientists, colleagues and friends 💜💙🩵

📢 We are hiring! 📢

We are looking for a postdoc to help us work out why mice cannot regenerate the spinal cord but spiny mice *can*.

More info and how to apply: tinyurl.com/4m6yzbef

Get in touch if interested!

Couple of opportunities up to join the group!
One at postdoc level, but open to senior support path.
One research assistant role.
Please share, or drop a line if you want to learn more!
Or just apply!
Thanks!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Congrats Juliet 👏🏻🥳

1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce".

Prepare to get cheesy, I'm glad to share the Cacio e paper preprint:

arxiv.org/abs/2501.00536

Preprint alert: Using human microneurography protocols in PatchSeq experiments on pig DRGs we identify the molecular identity of human dermal CMi-fibers (sleeping nociceptors). We provide an integrated pig-human-more transcriptomic atlas and identify OSMR and SST as marker, backed by human expts.

People living with multiple sclerosis #MS could be prescribed personalised treatment in future, helped by research published in Neuron today in which Prof Anna Williams and colleagues studied more than half a million brain cells. @mssocietyuk
regeneration-repair.ed.ac.uk/personalised...
#CRM

The 25 days of chRistmas: an R advent calendaR Thank you for your interest in this advent calendar and learning R! R is a powerful tool for data analysis and visualization. At first, it can be really overwhelming, but after you pick up the basics,...

It's Dec 1 and you want to finally start learning R? The R advent calendaR by @kiirsti.bsky.social is an excellent place to start. Do it now! #rstats kiirstio.wixsite.com/kowen/post/t...

My first first author paper is out!
doi.org/10.3390/gene...

Main message: 💸 Less expensive sequencing methods can provide just as good quality single-cell data 📊

With David A. D. Munro, Meryam Beniazza, Josef Priller, @annawilliamslab.bsky.social, Andrea Corisnotti