Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS - BMC Medicine Background Iron deficiency (ID) is proposed to be involved in cognitive aging and dementia; however, empirical data is lacking to support this hypothesis. We examined the association between absolute and functional ID and incident dementia diagnosis. Methods Data from 70,935 individuals aged ≥ 50 years from the Swedish AMORIS cohort, who had blood measurements indicative of iron status between 1985–1996, were used. Participants were followed for incident dementia diagnosis recorded in National Patient Register (inpatient and specialist outpatient) and Prescribed Drug Register (dispensed anti-dementia drugs) for up to 15 years. Two exposure groups were defined: absolute iron deficiency (serum ferritin < 30 ug/L) and functional iron deficiency (transferrin saturation < 20% and serum ferritin ≥ 30 ug/L). The reference group included individuals with measurements in the normal range of hemoglobin, serum iron, and total iron binding capacity. Results A total of 4,994 individuals received a dementia diagnosis over a mean of 12.6 years. Compared with the reference group, absolute and functional ID was associated with increased dementia diagnosis (adjusted hazard ratio (HR) = 1.24, 95% confidence interval (CI): 1.18–1.42; HR = 1.21, 95% CI: 1.05–1.39, respectively), after adjusting for age, sex, education, and comorbidities. The associations were essentially consistent across subgroups, and when further adjusting for kidney function, body mass index, and smoking in subsamples. Conclusions Even though absolute and functional iron deficiency has different underlying mechanisms, we found that both conditions are associated with an increased risk of dementia. Considering that iron deficiency is a pervasive but often neglected health issue in older adults, resolving iron deficiency may be relevant for dementia prevention.

Addressing iron status may be relevant for #dementia prevention and healthy #ageing, suggests a KI study published in BMC Medicine @bmc.springernature.com. Both absolute and functional iron deficiency were linked to higher dementia risk in older adults. 🧪 #aging doi.org/10.1186/s129...

Mistakes in Pancreatic exocrine insufficiency and how to avoid them Pancreatic exocrine insufficiency (PEI) is a common yet frequently under-recognised cause of maldigestion, malabsorption, and malnutrition. Although traditio...

💡 Pancreatic exocrine insufficiency (PEI) is common, yet frequently unrecognised. PEI is a common driver of malnutrition. PEI is a maldigestion syndrome that demands a structured, context-driven approach.
@myueg.bsky.social

🔗 Access the full article on Gutflix: bit.ly/4mDbeJF

Detecting cancer early can dramatically improve outcomes.
This week's glossary carousel explains:
• Diagnosis
• Screening
• Early detection

These concepts are central to ongoing research aimed at improving survival rates for pancreatic cancer.

#EarlyDetection #CancerAwareness #PancreaticCancer

Following the #guidelines for #pancreaticexocrineinsufficiency supported by @myueg.bsky.social @uegj.bsky.social , we put together a review covering the important aspects, now published in a @elsevierconnect.bsky.social journal, @eclinicalmed.bsky.social
authors.elsevier.com/sd/article/S...

Reprogramming regulatory T cells could help immunotherapy work in pancreatic cancer Researchers at Oregon Health & Science University have uncovered a key reason why immunotherapy has largely failed in pancreatic cancer—and identified a promising strategy to overcome that resistance....

medicalxpress.com/news/2026-04...

🥗 Sucrase-isomaltase variants do not influence #FODMAP diet outcomes in #IBS

🔸 54% carried ≥1 hypomorphic SI variant
🔸 Initial & long-term diet response similar across genotypes
🔸 Dietary intake unaffected by carrier status

Read more in UEG Journal:
👉 https://bit.ly/4vhwxoj

This is the way to go! As we are doing w/ @pancaid.bsky.social

KRAS G12D - that’s the one for #pancreaticcancer!

www.mdanderson.org/newsroom/res...

PCE is pleased to introduce Patrycja Rzadkowska, Patient & PCE Vice Chair, Poland for the upcoming masterclass:

Patrycja will share insights on supporting patients in the disease process, emphasising patient-centred care.

📅 Monday, 27 April 2026
🕒 13:45 – 17:00 CEST
📍 Grand Hotel Excelsior Malta

Gut bacteria appears linked to how much latent #HIV remains in the blood during antiretroviral therapy, a study in Gut Pathogens shows. Findings suggest the gut #microbiome may influence how much virus persists in the body 🧪
news.ki.se/gut-bacteria...

On #WorldHealthDay, we are reminded that health is a fundamental right, yet for many people affected by pancreatic cancer, timely diagnosis, access to treatment, and quality care remain out of reach. Today, we stand united to change that. 🌍💜

Pathophysiology of colitis-associated colorectal cancer Nature Reviews Gastroenterology & Hepatology, Published online: 01 April 2026; doi:10.1038/s41575-026-01197-6In this Review, Neufert and Neurath discuss the pathophysiological mechanisms of colitis-associated colorectal cancer, focusing on the tumour epithelium, stromal cells, mucosal barrier and mechanisms of tumour development. They also discuss potential implications for personalized therapy.

ICYMI: New online! Pathophysiology of colitis-associated colorectal cancer

The microbiome regulates host metabolic health and diseases through microbial enzymes Nature Reviews Gastroenterology & Hepatology, Published online: 07 April 2026; doi:10.1038/s41575-026-01195-8In this Review, Jiang and colleagues describe how gut microbial enzymes regulate host metabolic health and diseases. They also discuss the methodology for studying gut microbial enzymes and their potential clinical applications.

New online! The microbiome regulates host metabolic health and diseases through microbial enzymes

Important Meeting to raise awareness for #pancreaticcan er

JAMA Clinical Guidelines Synopsis: Management of Crohn Disease in Adults, published online April 8, 2026. Guideline title: Management of Crohn's Disease in Adults. Release date June 3, 2025. Prior version April 2018.

📊 JAMA Clinical Guidelines Synopsis: #CrohnDisease guidelines recommend fecal calprotectin for screening and monitoring, routine colonoscopy for colorectal cancer, and oral budesonide for induction in mild to moderate ileocecal disease.

ja.ma/47QA5ng

»Es gibt keine parteipolitischen Inhalte in Physik, Chemie, Biologie oder Mathematik. Wenn wir über den zweiten Hauptsatz der Thermodynamik reden, reden wir über kein Parteiprogramm. Wenn das Thema Klima immer wieder in eine parteipolitische Ecke geschoben wird, ist das Bullshit« Harald Lesch

#wemezeclassics

Purple background featuring pink and white decorated eggs, small sprigs of greenery, and two gift boxes wrapped with pink ribbons. Below, it reads: "Sending love and hope to the Let's Win community this Easter." The Let's Win Pancreatic Cancer logo is at the bottom.

Sending love and hope to the Let's Win community this Easter. 💜

Women are important for science and science needs more women.

Women play a vital role in science. A powerful reminder from mRNA researcher and Nobel Prize winner Prof. Katalin Karikó on why science needs more women!

#diabetes can cause #pancreaticexocrineinsufficiency after year of insulin dependency! See the recent @myueg.bsky.social guidelines published in @uegj.bsky.social

How the PRECEDE Consortium is Redefining Pancreatic Cancer Detection | CancerNetwork Diane Simeone, MD, detailed how the PRECEDE Consortium utilizes standardized data sharing and high-risk screening to identify stage I pancreatic cancer.

www.cancernetwork.com/view/how-the...

DAS! Rote Sofa: Medizinhistoriker Philipp Osten über 'besiegte' Krankheiten - hier anschauen Die Geschichte der Menschheit ist auch eine Geschichte des Überlebens. Wo wüsste man das besser als im Medizinhistorischem Museum in Hamburg. Dort klärt Medizinhistoriker Philipp Osten darüber auf, we...

Vier Stunden lang ein NDR Team zugetextet, Andras Moll hat allen Unsinn rausgeschnitten und kunstvoll einen Dreiminüter daraus gebastelt.

As we continue sharing key chapters from the Treatment Opportunities and Pancreatic Cancer booklet, we now focus on Chapter 5: Supportive and palliative care. 🏥 

👉 Download the resources to learn more: pancreaticcancereurope.eu/project/treatment-opport...

Some (more) light at the end of the tunnel

Applications for UEG Summer School 2026 are opening in one week, on January 15 – mark your calendar and get ready!

🆕 New for 2026: Extended to three full days for even more practical training and collaboration
📍 11 – 14 June, Prague, Czech Republic

🔗 Learn more: https://bit.ly/3qTAD6C

Today, I leave as the president of @myueg.bsky.social It was a pleasure to serve our federation "onwards & upwards"! Handover of office was during #UEGWeek; @joostphdrenth.bsky.social was a phantastic vice president and will serve as an excellent president! This is the last #selfiewiththepresident

We are proud that our comment on the future of #treating #pancreaticexocrineinsufficiency with #pancreatin will be the opening article for @natrevgastrohep.nature.com in 2026!
doi.org/10.1038/s415...

This #grandchallege #PANORAMA study was part of our #PANCAIM 🇪🇺 project led by @radboudumc.bsky.social

The image shows a large promotional display for "UEG Week", with a giant green "ueg" text sculpture in the foreground and a colorful graphic banner welcoming visitors to the event.

Today is International Volunteer Day – and the perfect moment to say a big THANK YOU to our wonderful volunteers. Your dedication, passion, and support make everything we do possible. We couldn’t do it without you!

@maloehr.bsky.social​

Today is the day!