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Posts by Falk Hildebrand

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Changes in antimicrobial resistance profiles of Escherichia coli and the metagenome on Dutch pig farms after antimicrobial usage interventions - npj Antimicrobials and Resistance npj Antimicrobials and Resistance - Changes in antimicrobial resistance profiles of Escherichia coli and the metagenome on Dutch pig farms after antimicrobial usage interventions

Just out in npj Antimicrobials & Resistance @natureportfolio.nature.com

www.nature.com/articles/s44...

We looked at what actually happens to AMR on pig farms when you reduce antimicrobial use through real-world, coaching-based interventions.

3 days ago 10 6 2 0
A social card with a photo of the Quadram Institute with pink blossom in the foreground. There is the text "Chair of the QIB Board of Trustees, an established scientific leader, with proven experience and capabilities to serve as Chair of our Board of Trustees. Apply by 11 May 2026"

A social card with a photo of the Quadram Institute with pink blossom in the foreground. There is the text "Chair of the QIB Board of Trustees, an established scientific leader, with proven experience and capabilities to serve as Chair of our Board of Trustees. Apply by 11 May 2026"

🆕 We are seeking an established scientific leader, with proven experience and capabilities to serve as Chair of the QIB Board of Trustees.

🗓️ Apply by 11 May 2026
➡️ buff.ly/rlL2jAU

5 days ago 3 6 0 0
A social media card with a photo of fermented food and the text "Research Scientist (Data Science) to investigate how novel fermented plant-based foods influence the human gut microbiome, Salary: £37.500 to £43,350, Contract length: 2 years, Apply by 17 May 2026"

A social media card with a photo of fermented food and the text "Research Scientist (Data Science) to investigate how novel fermented plant-based foods influence the human gut microbiome, Salary: £37.500 to £43,350, Contract length: 2 years, Apply by 17 May 2026"

🆕 Vacancy! We’re looking for a Research Scientist (Data Science) to join Professor @bioinf.bsky.social 's group to investigate how novel fermented plant-based foods influence the human gut microbiome 📊

💷 £37,500 to £43,350
🗓️ Apply by 17 May 2026
➡️ buff.ly/X88I01N

1 week ago 9 10 1 0
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🆕 Vacancy! We’re looking for a Research Scientist (Metagenomics) to join Professor @bioinf.bsky.social 's group to investigate how bacterial genomes evolve in closely related family members 🧬

💷 £37,500 to £43,350
🗓️ Apply by 17 May 2026
➡️ buff.ly/HggGS1j

6 days ago 3 7 1 0
Toward ethical human microbiome research: improving health through radical interdisciplinary and intercultural co-laboration - Microbiome As human microbiome research is globalizing, it raises ethical concerns regarding the European and North American dominance in the field, which may reproduce a colonial bias and perpetuate inequities in global health research and outcomes. We suggest disentangling this ethical quandary into three main concerns: 1) scientific bias toward European and North American populations; 2) limited meaningful community inclusion, participation, and ownership, and 3) scant significant inclusion of diverse global researchers. We then formulate three recommendations for their resolution, deploying co-laboration—joint labor of diverse partners in generating synergies between diverse disciplines, cultures, and knowledges around shared concerns—and co-laborative science—a form of citizen science based on such synergies between diverse partners—to guide meaningful inclusive, participatory, and ethical human microbiome research. To conclude, we promote a programmatic list for putting co-laborative ethical science into practice, benefiting global communities, individuals, and researchers alike and decolonizing and improving health worldwide.

The importance of sharing data and equivalizing sampling efforts of microbiome research across continents by @raeslab.org and colleagues: link.springer.com/article/10.1...
Well spoken, let's all put this into action now!

1 week ago 3 0 0 0
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Host immunogenetic variation and gut microbiome functionality in a wild vertebrate population - Microbiome Background The gut microbiome (GM) –important for host health and survival– is partially shaped by host immunogenetics. However, to date, no study has investigated the influence of host Major Histocom...

Thank you for sharing! It was a pleasure to work with @bioinf.bsky.social on this project.

Read the full paper here: doi.org/10.1186/s401...

1 month ago 2 1 0 0
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The human gut microbiome in enteric infections: from association to translation Enteric infections remain a leading global cause of morbidity, mortality and economic loss, increasingly compounded by the rise of antimicrobial resistance. The gut microbiome — spanning bacteria, ...

Our team wrote a review for Gut Microbes on the role of the gut #microbiome in modulating enteric infections. Great team effort by Qi Yin, @samriddhigupta.bsky.social and Efrat Muller: www.tandfonline.com/doi/full/10....

3 months ago 10 5 0 0
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In #Microbiome

🚨Introducing MicroPhrophet: a personalized, temporal‑aware framework that accurately forecasts microbial abundance trajectories from incomplete longitudinal data, without the need for data imputation

Read more 👉 doi.org/qk8x #OpenAccess

3 months ago 3 1 0 0

I want to thank the funders, @earlhaminst.bsky.social @quadraminstitute.bsky.social and Anthony, Wing, Kasia, Chris and @cfrioux.bsky.social for help in this project.

3 months ago 3 0 0 0
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cvaNMF is not only useful for microbiomes, but can also be used to discover e.g. 3 signatures describing tumor stages and progression in single cell sequencing data, while identifying key cell types in each.

3 months ago 0 0 1 0
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Several other environments were tested, but to mention soil metagenomes, here we described the "Terrasignatures" that can reliable describe different components of soil. The fine grained nature of allows to reconstruct geographic distances between samples (on 5 Terrasignatures):

3 months ago 0 0 1 0
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In a gut metagenome collection* we re-found a) the original Enterosignatures and b) how these can classify diseases using only 5 enterosignatures

*recommend read: enterotypes from @borklab.bsky.social: doi.org/10.1101/2024...

3 months ago 1 0 1 0
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At it's heart, cvaNMF is a pipeline to ease the computing and k-selection of the NMF method used before. We show that the pipeline can - computationally efficient and in stable API - recover signatures from various datasets and propose a new algorithm to discover the optimal signature number.

3 months ago 0 0 1 0
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Detecting signatures underlying the composition of biological data Abstract. Biological compositional data is inherently multidimensional and therefore difficult to visualize and interpret. To allow for the automatic decom

Led by Anthony Duncan, and after much hard work, we have now published an Enterosignature follow-up paper: cvaNMF

academic.oup.com/nar/article/...
This work represents a generalization of the Enterosignature (ES) framework e.g. discovering ES disease associations, and describe "Terrasignatures"
👇👇👇

3 months ago 5 8 1 0
British Reporter DISMANTLES Trump Bootlicker With ONE Simple Question!
British Reporter DISMANTLES Trump Bootlicker With ONE Simple Question! YouTube video by Brit With a Mic

That's a well-prepared journalist, well done: www.youtube.com/watch?v=ufkt...

4 months ago 0 0 0 0
PhD Exploring the genetics of gut microbiomes spatially resolved in IBD patients (HILDEBRAND_Q26MMB) 2026/27 | UEA PhD Exploring the genetics of gut microbiomes spatially resolved in IBD patients (HILDEBRAND_Q26MMB) 2026/27 | UEA

PhD opportunity at the @quadraminstitute.bsky.social in my group: using population genetics we will explore bacterial evolution in IBD patients in a so far unprecedented spatiotemporal resolution: www.uea.ac.uk/course/phd-d...
Deadline: 6th Jan

5 months ago 5 0 0 0
PhD PhD Opportunity: Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome (HILDEBRAND_Q26DTP) 2026/27 | UEA PhD PhD Opportunity: Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome (HILDEBRAND_Q26DTP) 2026/27 | UEA

PhD opportunity: Exploring the western gut microbiome and how these transfer between family members (2nd Dec 25 deadline).
www.uea.ac.uk/course/phd-d...
This bioinformatic-project will teach high-resolution metagenomics, population genetics, mobile DNA and about bacterial species theory. Please RT

5 months ago 4 4 0 0
PhD position advertisement that reads "Funded PhD. Exploring the genetics of gut microbiomes spatially resolved in IBD patients. With Professor Falk Hildebrand. Apply by 6 January 2026."

PhD position advertisement that reads "Funded PhD. Exploring the genetics of gut microbiomes spatially resolved in IBD patients. With Professor Falk Hildebrand. Apply by 6 January 2026."

🆕We’re looking for a motivated candidate to explore the evolution of the gut microbiome in patients with Inflammatory Bowel Disease, working on cutting-edge metagenomics with clinical translation 🧬

🗓️ Apply by 6 January 2026
➡️ buff.ly/dFWnLv7

@bioinf.bsky.social

5 months ago 5 3 0 1
A digital illustration of the gut microbiome with the text "Funded PhD, Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome, with Dr Falk Hildebrand, Apply by 2 December 2025"

A digital illustration of the gut microbiome with the text "Funded PhD, Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome, with Dr Falk Hildebrand, Apply by 2 December 2025"

🎓 #PhDPosition !

🍔 Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome with Dr Falk Hildebrand @bioinf.bsky.social

📅Apply by 2 December

➡️ buff.ly/nZfTKMR

6 months ago 0 2 1 0
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Linking antimicrobial resistance, climate warming, and carbon use efficiency in Arctic soils (HERNANDEZ-GARCIA_UEA_ARIES26) at University of East Anglia on FindAPhD.com PhD Project - Linking antimicrobial resistance, climate warming, and carbon use efficiency in Arctic soils (HERNANDEZ-GARCIA_UEA_ARIES26) at University of East Anglia, listed on FindAPhD.com

PhD opportunity to work in my lab at UEA, together with @drbradbrad.bsky.social and Marc Dumont “Linking AMR, global warming and CUE in deglaciated soils”

www.findaphd.com/phds/project...

6 months ago 12 14 0 1
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Same.

#AlsoTiredOfWaitingForTheEPSTEIN_Files

6 months ago 42105 9995 1853 849

Interested in modelling metabolism from food -> gut microbiome -> blood ? 5 days left to apply for a fully funded position to investigate this. 👇👇👇

6 months ago 2 3 0 0
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Postdoctoral Research Scientist - Soil Microbiomes

Applications close soon for a postdoctoral researcher to join Dr Falk Hildebrand and Dr Chris Quince at the Earlham Institute, looking at microbial perspectives into land use & climate scenarios.

buff.ly/wR1Ym1z

#SoilHealth #Microbial #SciJobs @bioinf.bsky.social

7 months ago 3 3 0 0
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We want to explore the metabolic interactions among gut bacteria, when the human host eats different foods - maybe this explain partly the Enterosignature structure?
Please do apply for our bioinformatic post to explore this question in metagenomes: jobs.quadram.ac.uk/Details.asp?...

7 months ago 10 6 1 1
Earlham Institute

Only 5 days left to apply for our Soil metagenomics position: estimating the impact microbiomes in restored agricultural sites can have on climate change (closing 19th Sep):
jobs.earlham.ac.uk/Details.asp?...

7 months ago 6 5 0 0
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How do you long-read sequence metagenomes? I would argue it starts with the right sample storage & DNA extraction, to enable efficient @nanoporetech.com /@pacbio.bsky.social sequencing, which we investigated in our new paper: www.biorxiv.org/content/10.1...

Massive thanks to Klara for driving this

7 months ago 42 24 0 0
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New project explores potential of soil microbes to achieve UK net zero goals How does different land uses impact soil microbes and their contribution to carbon storage?

Researchers at the Earlham Institute and @quadraminstitute.bsky.social are studying the role of #soil #microbes in carbon storage, and how different land uses impact these communities. 🦠💻🌱🧬

👉 buff.ly/5f1Eo64

@bioinf.bsky.social @tyndallcentre.bsky.social

7 months ago 7 7 1 0
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New project explores potential of soil microbes to achieve UK net zero goals - Quadram Institute Researchers are combining the latest science in climate forecasting and soil science to understand how land use management could enable soil carbon storage

🆕 New project explores potential of soil microbes to achieve UK net zero goals

Providing expertise in cutting edge methodologies for studying microbes, @bioinf.bsky.social and Dr Chris Quince, Group Leaders at the Quadram Institute & Earlham Institute, will together explore key research questions.

7 months ago 0 2 0 0
An illustration of a network with the text "Metagenomics Research Scientist, to join Falk Hildebrand's group to study the diet impact on the gastrointestinal microbiome. Salary: £37,500 to £42,000, Contract length: 2.5 years, Apply by 30 September 2025"

An illustration of a network with the text "Metagenomics Research Scientist, to join Falk Hildebrand's group to study the diet impact on the gastrointestinal microbiome. Salary: £37,500 to £42,000, Contract length: 2.5 years, Apply by 30 September 2025"

🆕 Vacancy! We’re looking for a #Metagenomics Research Scientist to join the Laboratory of Dr Falk Hildebrand @bioinf.bsky.social to study diet impact on the gastrointestinal microbiome.

💷 £37,500 - £42,000
🗓️ Apply by 30 September 2025
➡️ buff.ly/uwqGQQm

7 months ago 6 7 1 0
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Quadram Institute

Last two days to apply for postdoc in my lab, a bioinformatic post to model metabolite fluxes in the gut microbiome during different diets:
jobs.quadram.ac.uk/Details.asp?...

8 months ago 1 0 0 0