Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis www.nature.com/articles/s42...

Alzheimer’s disease risk protein SorLA regulates ER homeostasis and lipid metabolism in human microglia, with conserved effects in neurons - Acta Neuropathologica Microglial dysfunction is a hallmark of Alzheimer’s disease (AD), yet the molecular mechanisms driving these impairments remain poorly defined. Genetic studies implicate several AD-associated genes in...

Alzheimer’s disease risk protein SorLA regulates ER homeostasis and lipid metabolism in human microglia, with conserved effects in neurons link.springer.com/article/10.1...

Lysosomal salvage of neuronal lipids enables glial infiltration of synaptic regions The complex morphologies of neurons and glia emerge through profound changes in membrane lipids and proteins during development. Lysosomes are central…

Lysosomal salvage of neuronal lipids enables glial infiltration of synaptic regions www.sciencedirect.com/science/arti...

Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion - Nature Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell r...

Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion www.nature.com/articles/s41...

Congratulations! 🎉

ACSS2 maintains oligodendrocyte progenitor cell pool and is required for myelination during development and aging - Nature Aging The mechanisms underlying impaired myelination during aging remain incompletely understood. Here, Gao et al. report that ACSS2-mediated acetate utilization is essential for maintaining the oligodendro...

ACSS2 maintains oligodendrocyte progenitor cell pool and is required for myelination during development and aging www.nature.com/articles/s43...

Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

Intestinal macrophages modulate synucleinopathy along the gut–brain axis www.nature.com/articles/s41...

Cellular mechanisms of brain lipid metabolism in health and disease - Nature Cell Biology This Review discusses brain lipid metabolism from a cellular perspective, focusing on lipid uptake, de novo synthesis, storage, breakdown and intercellular transfer, and highlights its emerging implic...

Cellular mechanisms of brain lipid metabolism in health and disease www.nature.com/articles/s41...

Sleep-dependent clearance of brain lipids by peripheral blood cells - Nature Peripheral macrophage-like haemocytes in Drosophila promote sleep by clearing lipid buildup in the brain, helping to maintain metabolic homeostasis and brain function and fitness.

Sleep-dependent clearance of brain lipids by peripheral blood cells www.nature.com/articles/s41...

Spatially resolved transcriptome–metabolome integration reveals region-specific glial lipid dysregulation associated with Alzheimer’s pathology www.biorxiv.org/content/10.6...

Dying oligodendrocytes persist without mitochondria www.biorxiv.org/content/10.6...

Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...

Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors www.science.org/doi/10.1126/...

Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice Brain myeloid cells accumulate neutral lipids in multiple human neurodegenerative disorders and relevant mouse models. These lipids are often assumed …

Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice www.sciencedirect.com/science/arti...

Here, long-term high-fat diet in ♂️🐭 induced anxiety- & depression-like behavior + ⬆️ lipid droplet–accumulating microglia, linking microglial lipid storage to neuroinflammation, which may underlie obesity-related psychiatric comorbidities

Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...

Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.

Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com

Postdoc Portrait: Priya Prakash This postdoc uncovers how glial dysfunction drives neurodegeneration in a rare movement disorder.

I was featured on The Scientist as a part of their 'Postdoc Portraits' series where I spoke about my scientific career path and ongoing work on oligodendrocyte dysfunction in neurodegeneration. Check it out! www.the-scientist.com/postdoc-port...

PREPRINTS ON THEIR WORK:

Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...)

Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)

#SfN #SocietyForGlia
STARTING NOW!

Ending strong with the last www.liddelowlab.com presentations of the week.

@pryprk.bsky.social
talking about a world first mouse model for XDP... and OLIGODENDROCYTES!

@melcooperphd.bsky.social
presenting on astrocyte networks in the mouse forebrain.

IT'S A BUSY AFTERNOON FOR THE LAB!

@mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain

Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?)

@liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity

Congrats to our very own Ipshita Zutshi on being awarded the Peter & Patricia Gruber International Research Award in Neuroscience!! #SfN25

Advances in the genetics and pathology of Lewy body dementia Lewy body dementia is a heterogeneous disease that is underdiagnosed and poorly understood. Pathologically, Lewy body dementia is characterised by the…

Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...

Looking forward to presenting our work on oligodendrocyte dysfunction in a rare neurodegenerative movement disorder X-linked Dystonia Parkinsonism. Come say hi if you're around on Tuesday, Nov 18 between 1-5 pm! @sfn.org #SfN2025 #SfN25

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preprints:

@melcooperphd.bsky.social - astrocyte networks pubmed.ncbi.nlm.nih.gov/40777296/

@mrodea.bsky.social - single cell analysis & diversity www.biorxiv.org/content/10.1...

@pryprk.bsky.social - XDP www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...

See you in San Diego

@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.

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Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate Cao et al. show that hepatic hydrolysis of acetyl-CoA by acyl-CoA thioesterase 12 serves as a crucial source of circulating acetate mediating liver-brain communication, which signals the brain to buff...

Liver-brain axis in neuroinflammation. Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate. www.cell.com/cell-metabol...

Spatial dynamics of brain development and neuroinflammation - Nature A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...

Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke - Nature Metabolism Persistent microglial activation upon ischaemic injury leads to the formation of stroke-associated foamy microglia, perpetuating long-term inflammation, white matter damage and functional impairments....

Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke www.nature.com/articles/s42...

Heartbreaking, well crafted thread from an immigrant scientist who’s decided being in the US isn’t worth the struggle anymore.

After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.

Oligodendroglial fatty acid metabolism as a central nervous system energy reserve - Nature Neuroscience Brain functions require a constant supply of glucose. However, the brain energy stores are unclear. Here, the authors show that oligodendroglial fatty acid metabolism can be an energy reserve for whit...

Oligodendroglial fatty acid metabolism as a central nervous system energy reserve www.nature.com/articles/s41...