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Posts by Elliot H Smith, PhD

Nice! one minor critique: The FR increases are too subtle. You have to know what you're looking for to pick them out.

1 week ago 4 0 0 0
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For ~100 years, neuroscience assumed electrical stimulation excites neurons. Deliver current, cells depolarize, done.
That assumption is wrong.

1 week ago 9 4 1 0

tired: meta-analysis, wired: mega-analysis...

2 weeks ago 1 0 0 0

Armageddon is terrible, but our only other option was diversity trainings at work.

2 weeks ago 43550 10919 186 280
Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey - Scientific Data Scientific Data - Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey

Want a dataset to test ideas on neural basis of decision making or how areas interact as we make choices? Check out our data published today @rudebecklab.bsky.social. >16,000 single neurons from 22 anatomically confirmed areas in macaques performing a decision task. www.nature.com/articles/s41...

2 weeks ago 104 34 2 1

Saw this at sundance this year: it's jam-packed with information on how the G in AGI comes straight out of eugenics, and eugenicist psychology and statistics.

2 weeks ago 3 1 0 0
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Wanna do neuroscience in Paris but can't find interesting lab?

Want to come do a sabbatical but don't know who to collaborate?

Check this webpage aggregating ~all the neuroscience labs (+200) in Paris.

⚠️only the information of 'verified' profiles is reliable⚠️

Please retweet 🙏

parisneuro.fr

2 weeks ago 126 71 2 2

argh! I'm in the same boat this cycle.

2 weeks ago 2 0 0 0

tell your PI now about how close you are cutting it for the CCN deadline 🙈

3 weeks ago 8 1 0 0
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🚨 We're very happy to introduce TRIBE v2: a foundation model of the brain's responses to sight, sound & language.

📄 Paper: ai.meta.com/research/pub...
▶️ Demo: aidemos.atmeta.com/tribev2/
💻 Code: github.com/facebookrese...
🤗 Model: huggingface.co/facebook/tri...

3 weeks ago 57 19 3 5
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🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social

We gave a worm brain control of a fly body and it walked

What did we learn? Nothing, other than deep reinforcement learning is effective

We call it the digital sphinx

www.biorxiv.org/content/10.6...

4 weeks ago 397 147 9 27
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Neuroanatomy reflects individual variability in impulsivity in youth - Molecular Psychiatry Molecular Psychiatry - Neuroanatomy reflects individual variability in impulsivity in youth

Our latest work looking at the neuroanatomical basis of impulsivity in youth is out now in Molecular Psychiatry!

4 weeks ago 38 24 2 2
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How does the cerebellum contribute to cognitive functions? The role of the cerebellum in motor functions is well understood. But why is the same circuitry engaged in functions such as working memory, language, and social cognition? This Unsolved Mystery looks...

Also out today - A quick intro piece on the role of the cerebellum in cognition. What does it do? How will we find out? This is what @actlab.bsky.social and I think the critical questions are right now. It was fun to write - especially the section on evolution....

journals.plos.org/plosbiology/...

4 weeks ago 95 40 3 4
NOT-OD-26-047: Request for Information (RFI): Inviting Comments and Suggestions on a Framework for the NIH-Wide Strategic Plan for Fiscal Years 2027-2031 NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI): Inviting Comments and Suggestions on a Framework for the NIH-Wide Strategic Plan for Fis...

The form is short. You can submit anonymously. Even one sentence counts.

"I want NIH to fund the best science based on merit, not politics" is a valid comment.

Deadline: May 16, 2026
grants.nih.gov/grants/guide...

1 month ago 7 8 2 1
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Postdoc Position: Affective Neuroscience and Computational Psychiatry at the Donders Centre for Cognitive Neuroimaging | Radboud University Do you want to work as a Postdoc at the Faculty of Social Sciences? Check our vacancy!

Join us for a postdoc @ the Donders Institute; application deadline March 24.
www.ru.nl/en/working-a...

1 month ago 41 49 2 0

💯💯

1 month ago 0 0 0 1
Cosyne 2026 - Cosyne Tutorial: Comparative Analysis of Neural Population Codes
Cosyne 2026 - Cosyne Tutorial: Comparative Analysis of Neural Population Codes YouTube video by Cosyne Talks

Cosyne invited me to give a long tutorial (4 hours!) on methods to quantify differences high-d neural recordings across animals, brain regions, deep neural nets, etc.

The recording is up on youtube. I hope it inspires more research on this fundamental topic!

www.youtube.com/watch?v=n44x...

1 month ago 160 56 3 1
Human claustrum neurons encode uncertainty and prediction errors during aversive learning Flexible behavior depends on continuous updating of internal models, yet the neural circuits coordinating this process remain poorly understood. The claustrum reciprocally connected to nearly the entire neocortex is uniquely positioned to influence cortical processing. Here we report single-neuron recordings from the human claustrum during aversive learning, with anterior cingulate cortex and amygdala recordings for comparison. Claustrum and anterior cingulate neurons displayed structured, task-related responses. Distinct subpopulations encoded stimulus onset and action-contingent outcomes, with outcome representations diverging between regions. Critically, both regions encoded model-derived latent variables uncertainty and prediction error but with different temporal profiles: only the anterior cingulate carried uncertainty signals during the intertrial period, while both regions encoded uncertainty and prediction error during the active-avoidance period. The amygdala, by contrast, showed minimal latent-variable modulation. These findings provide evidence that human claustrum neurons track higher-order cognitive variables not directly observable from sensory input, and reveal dissociable roles for the claustrum and anterior cingulate cortex in tracking latent task states. ### Competing Interest Statement The authors have declared no competing interest. NIH Common Fund, https://ror.org/001d55x84, R01MH138291 (ECD) Wellcome Trust, https://ror.org/029chgv08, 310142/Z/24/Z

Super cool new preprint showing that neurons in the human claustrum represent uncertainty and prediction errors.

www.biorxiv.org/content/10.6...

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Super congrats, Christina!! 👏👏🙌

1 month ago 1 0 1 0

I am thrilled to announce that our group has received a new grant from the Shurl and Kay Curci Foundation to study the neural dynamics of vocal learning in children! I am looking for a postdoc to join us in this effort, currently funded for 2 years. Please reach out with CV and letter of interest.

1 month ago 24 9 1 0
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A cognitive map for value-guided choice in the ventromedial prefrontal cortex Value-based decision-making can be conceptualized as navigation within a cognitive map of choice values. During choice, the ventromedial prefrontal cortex (vmPFC) compositionally builds cognitive maps...

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With Cosyne around the corner, I thought I would:

a) make a thread about our “A cognitive map for value-guided choice in the vmPFC” Cell paper (i'm a bit late). shorturl.at/DBA3H

1 month ago 39 11 1 4

Cite women. Full stop!
👏👏

1 month ago 13 4 1 0

#COSYNE2026 come check out Rikki Rabinovich’s poster today if you want to see some next-level neuroscience!

Decoding creativity state and level from human brain networks with CEBRA.

[3-121] Representations of divergent thinking in large-scale brain networks and single neurons

1 month ago 2 0 0 0
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Algorithmic representations of sequential behaviour in the human brain - 2-071. Friday.
@skuechenhoff.bsky.social, Habiba Azab

ABCD task in humans, with single cells and fMRI. Multiple different sequence representations, and a crazy anatomical organisation of the future in PFC.

1 month ago 4 1 1 0

personal note: There aren't words to adequately describe Nill's fortitude and perseverance in continuing to do great science during this horrendous time for her and her family in Tehran. She is an inspiration!

1 month ago 1 0 0 0
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We're currently digging into the brain data from the DRE patients and excited to discover the neural underpinnings of the context neglect that leads people to choose maladaptively when decks are shuffled.

There's a lot more in the preprint, here:

www.biorxiv.org/content/10.6...

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We've also been running the task with drug-resistant epilepsy patients and modeling their behavior. Interestingly, every aspect of the patients' behavior was indistinguishable from that of non-epileptic participants, except their choice times (DRE pts were slower to choose):

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The risk-sensitive models also best fit most participants' behavior, and critically, the latent risk-sensitive model variables (Q-values) best predicted participants' choices and response times:

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To do this, we first had several basic reinforcement learning models do the task, showing that asymmetric (AKA, risk-sensitive, 2-process distributional) reinforcement learning models (i.e., those learning from both gains and losses) performed best:

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a baby is laying on a blue pillow with the words `` hmmmm interesting '' written on it . ALT: a baby is laying on a blue pillow with the words `` hmmmm interesting '' written on it .

This behavior, that reflects the disCARDing ;) of a context that participants clearly learned, is similar to a well-known cognitive fallacy called base-rate neglect.

We then sought to understand whether there were some latent computational principles underlying this process.

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