Consensus Recommendations for Diagnosis and Management of Vanishing White Matter Dr. Justin Abbatemarco talks with Dr. Marjo S. van der Knaap and Romy J. van Voorst about expert consensus recommendations for the diagnosis and management of vanishing white matter and the importance...

Happy to share that Marjo van der Knaap and Romy van Voorst (Amsterdam Leukodystrophy Center) are featured on the Neurology Podcast, discussing international consensus recommendations for Vanishing White Matter.
🎧 Listen: directory.libsyn.com/episode/inde...
📄 Read: www.neurology.org/doi/10.1212/...

Steun het onderzoek naar gentherapie voor vanishing white matter (VWM)

Steun onderzoek naar gentherapie voor Vanishing White Matter (VWM)!

Jouw steun brengt ons dichter bij een oplossing! Het onderzoek biedt nieuwe hoop voor patiënten en families.

Doneren en meer info via de link:

www.zzf.nl/zzf-onderzoe...

#VWM #ZeldzameZiekten #Gentherapie

- job alert -

Will you become our colleague at the Amsterdam Leukodystrophy Center? See the PhD opening below, focusing on the molecular basis of fluid regulation by astrocytes in the brain. Apply using the link below:

🔗 werkenbij.amsterdamumc.org/en/publicatie-1179368

Vacatures - PhD Cellular Neuroscience - Astrocyte Physiology - Amsterdam UMC Amsterdam Leukodystrophy Center is looking for a motivated PhD candidate to explore the fundamental physiology of astrocytes in the brain, in the context of brain fluid regulation.

🚨 PhD position in astrocyte physiology!

Join us in Amsterdam to explore how astrocytes dynamically regulate brain water flow!

Apply using the link below:
🧠🔬🌍

🔗 werkenbij.amsterdamumc.org/en/publicatie-1179368

#Neuroscience #PhD #Astrocytes #MLC #SUPERGLUE

Impaired Volume Regulation and Electrophysiology of Astrocytes In Situ in a Mouse Model for Megalencephalic Leukoencephalopathy With Subcortical Cysts Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and exten...

Fresh from the lab!

In this new paper, PhD student Sven Kerst shows how phenotypes observed in isolated cell models for the leukodystrophy MLC are also observed in intact astrocytes in acute brain slices!

Glia | Neurobiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

Marjo van der Knaap has just opened the leukodystrophy symposium in Amsterdam, celebrating both 25 years of the ALC as well as Marjo’s farewell from clinical tasks.

We are very excited about the coming 2 days of white matter science!

Cell-specific Eif2b5 mutant mice: novel insights into roles of macroglia in vanishing white matter Vanishing white matter (VWM) is a leukodystrophy caused by a genetic defect in translation initiation, with astrocytes thought to play a key role. Triñanes

A new study from the ALC reveals how Eif2b5 mutations in different brain cell types (including oligodendrocytes and astrocytes) contribute to VWM.

Our findings challenge the idea that malfunction of a single cell type drives the disease.

Find the article at:
academic.oup.com/brain/advanc...

We examined differential effects of two frequently used anesthetics in various VWM models and conclude that propofol is preferable over sevoflurane in VWM patients.

🧠⚕️

Effect of Propofol and Sevoflurane on Vanishing White Matter Models The leukodystrophy vanishing white matter (VWM) most often has its onset in childhood and is characterized by chronic decline and additionally stress-…

⭐ New paper alert ⭐

Our recent work on anesthetics as potential stressor inducing acute decline in patients with vanishing white matter (VWM), is now published.

📖: www.sciencedirect.com/science/arti....

Excited to share our latest paper!

We argue that in MS, the primary immune attack isn’t on myelin or myelinated axons — but on the ion & water homeostasis machinery in astrocyte endfeet.

A short thread on this new perspective

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Vacatures - PhD Understanding and repairing astrocyte dysfunction in the leukodystrophy MLC - Amsterdam UMC The Amsterdam Leukodystrophy Center is searching for a motivated PhD candidate, for a collaborative project on understanding astrocyte dysfunction in the leukodystrophy MLC.

My first post in the sky is a:

Job Alert!

We are looking for a PhD student to study astrocyte dysfunction in the rare neurological disease MLC. Looking for a challenge? See the job advertisement below!

werkenbij.amsterdamumc.org/en/vacatures...

Could you add our center? Thanks!