My first, first author paper is now on #ScienceAdvances !

Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨
science.org/doi/10.1126/sc…

Huge thanks to @kazu-maeshima.bsky.social , for supervision.
Amazing collab with @rcollepardo.bsky.social ’s group! 1/

*POSTDOC Positions* Multiple positions open in my group at @biohub.org & @feinberg.northwestern.edu / @nitmb.bsky.social We welcome PhDs from diverse disciplines interested in QBio & BioE

job-boards.greenhouse.io/biohub/jobs/...
job-boards.greenhouse.io/biohub/jobs/...
www.goyallab.org/positions

Meiosis faces a fundamental problem:

It must repair hundreds of DNA double-strand breaks while executing a transcriptional programme essential for gamete development.

But many of these breaks occur in genes.

So how are these two processes reconciled?

www.biorxiv.org/content/10.6...

ChromSMF preprint is out!🚀
tinyurl.com/ChromSMF

We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting!

In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬

What does this unlock? ⬇️

Barkai lab work so instructive here!

A digital CAPTCHA verification window titled "Select all squares with PIPES" against a plain white background. The window contains a 3×3 grid of numbered squares, mixing literal hardware, smoking pipes, and programming syntax.

These captchas just keep getting harder #rstats

Have you ever wanted to do single-molecule biophysics in high-throughput? @matt-dejong.bsky.social (amazing joint grad student with @dunnlab.bsky.social) invented a way & measured >100,000 single molecules across 241 different sequences. (1/3)
www.biorxiv.org/content/10.6...

Happy to share our Current Opinion review on the key challenges in accurately predicting 3D distances between chromatin segments and computing their dynamics. Thanks to @djost-physbiol.bsky.social @lucagiorgetti.bsky.social for the invitation to write this review! @shuvadipdutta.bsky.social

I argued in a piece I wrote in 2013 called ‘the frustrated gene’ that caps are an antiviral defense. Hence some viruses steal caps, other have their own capping enzymes, while others evolved IRESs. Here’s a virus that captured the entire cap recognition machinery. Conflicts begets comlexity.

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Our paper is now out in Nature:

“Ancient co-option of LTR retrotransposons as yeast centromeres”

www.nature.com/articles/s41...

A short thread on how retrotransposons helped give rise to yeast point centromeres.

1/14

🚨 Requesting help:

I am looking for an agent who can facilitate more speaking gigs, podcast appearances, and interviews with journalists

I want to more widely share my story and expertise as a trans geneticist who understands the reality and complexity of "biological sex" 🏳️‍⚧️🧬

Please signal boost?

No justice, no science. Fuck ICE.

If you are a scientist funded by NIH and agree that if the HHS/NIH bill is held hostage by linkage for funding to DHS/ICE, we need to shutdown both and save lives, its time to speak up. Right now, with a few exceptions, the silence is deafening

Common variation in meiosis genes shapes human recombination and aneuploidy - Nature Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...

Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.

First authors: @saracarioscia.bsky.social & @aabiddanda.github.io

positive / negative feedback always a possibility though. To extend your analogy --> sound engineers in audience move around the crowd and update speaker output across the space depending on crowd (louder in some cases!). Point still stands but the details genome-wide are probably important too.

A picture of current members of the Groth lab

Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳

Oof.

Read in Nature: nature.com/articles/s41586-025-09899-8

Stress controls epigenetic inheritance!

A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
👉 nature.com/articles/s41586-025-09899-8

Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...

Oo send on over the list @reitergroup.bsky.social plz!!!

Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway.

And found a hidden RNA-decay axis from Piwi to the RNA exosome.

Ladies and gentlemen... the weekend. (also: you are important and are not alone 🧡)

Daniele's lab's work demonstrates clearly the link between loop extrusion and regulated gene expression; context & cell-type matter. Statements like "more about X, less about Y" are only useful if context is specified. Homology search isn't relevant in a post-mitotic cell type.

Known for decades: DNA sequence drives nucleosome "rotational positioning" (which face of DNA contacts histones)

But: How does this persist when remodelers & transcription constantly mobilize nucleosomes? Our new preprint 1/ :

www.biorxiv.org/content/10.6...

Escape from X inactivation is directly modulated by Xist noncoding RNA Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

Menin-MLL1 complex cooperates with NF-Y to promote hepatocellular carcinoma survival Chromatin regulators are frequently mutated or aberrantly expressed in hepatocellular carcinoma (HCC), suggesting that the dysregulation of chromatin …

www.sciencedirect.com/science/arti...

Cohesin guides homology search during DNA repair using loops and sister chromatid linkages Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...

@science.org🧬Cohesin guides homology search during DNA repair using loops and sister chromatid linkages | Science www.science.org/doi/10.1126/... @fedeteloni.bsky.social @danielgerlich.bsky.social et al.

Oh hey, looks like I can upload longer videos here now!
Here’s my most recent one covering the latest findings on ecDNA retention mechanisms from the Chang & Mischel labs.

Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.

Overview of Integrated Robotic Imaging and Sequencing, IRIS

We just released IRIS (7+yrs project), a tech we believe will transform cell biology by pairing high-resolution cell images with matched #scRNAseq, letting us interpret cellular form by its molecular ground truth.
Huge tx to @JohannesBues, @JoernPezoldt, @CamilleLambert et al.
shorturl.at/zgY8Z