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Posts by Laboratory for Physical Biology, RIKEN

A geometric framework for curvature-dependent collective behavior of polar active agents on curved surfaces In biological systems, active agents such as actomyosin and cells move and interact on curved surfaces, exhibiting diverse phenomena. These observations have motivated studies of how curvature shapes ...

New arXiv preprint: I develop a geometric framework to describe how cells and proteins move and collectively organize on curved surfaces, linking curvature to the dynamics of active agents. doi.org/10.48550/arX... #ActiveMatter

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【bioRxivプレプリント】Kalman-filter Force Inference(KFI):上皮形態形成のタイムラプス・イメージングデータから、細胞の力(細胞間接着の張力と細胞圧)を動的にベイズ/カルマンフィルターの枠組みで推定します。https://doi.org/10.64898/2025.12.19.695339 #Mechanobiology #Morphogenesis

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Kalman-filter Force Inference: an estimation framework for cellular forces from temporal evolution of epithelial morphogenesis Epithelial morphogenesis is orchestrated by cellular forces, such as cell junctional tension and cellular pressure. Therefore, elucidating the spatiotemporal distribution of these forces and their dyn...

New bioRxiv preprint: Kalman-filter Force Inference (KFI) estimates dynamic cellular forces (junction tensions and cell pressures) from time-lapse data of epithelial morphogenesis using a Bayesian/Kalman framework. doi.org/10.64898/202... #Mechanobiology #Morphogenesis

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プレプリント:連続供給のある“開放系”で、Dictyostelium KI細胞がcmスケールの多腕スパイラル(時計回り)を形成。実験+開放系キラルVicsekモデルにより、微弱な単細胞キラリティと供給フラックスが巨視的キラル秩序を生む原理を示します。 doi.org/10.48550/arX... #ActiveMatter

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New preprint: Chiral multi-armed spirals emerge in migrating cells under continuous supply. Experiments (Dictyostelium KI)+ an open chiral Vicsek model show how weak single-cell chirality + continuous supply generate macroscopic chiral order. doi.org/10.48550/arX... #ActiveMatter #Chirality

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分子スケールのキラリティが細胞スケールのキラリティへどう伝わるのか:本研究は eLife のレガシーモデルで受理・出版されました。動的な同心円状アクトミオシンパターンが細胞キラリティを駆動することを、イメージング・超解像顕微鏡・理論モデルで示しました。https://doi.org/10.7554/eLife.102296

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How chirality goes from the molecular scale to the cellular one: in our @eLife paper, we show that a dynamic concentric actomyosin pattern drives cell chirality, using imaging, super-resolution microscopy, and a theoretical model. doi.org/10.7554/eLif...

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【eLife論文(Legacyのaccept/rejectモデルで出版)】「ニワトリ原腸形成において、中胚葉細胞が動的なメッシュワーク構造を自己組織化する」。画像解析+トポロジカルデータ解析+理論モデルで裏付け、3Dメッシュワーク型の間葉系集団移動を示しました。https://t.co/t0acs8hkkx

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Lab for Physical Biology (RIKEN BDR): theory×experiment on cells & multicellular systems, chirality, polarity, mechanics, morphogenesis, collective behaviors, active matter. 理研BDR フィジカルバイオロジー研究チーム:細胞・多細胞の物理生物学. 論文・連絡先: phb.riken.jp

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Laboratory for Physical Biology

Our @eLife paper: “Migrating mesoderm cells self-organize into a dynamic meshwork during chick gastrulation.” Imaging + topological data analysis+ theoretical model, together reveal a 3D meshwork mode of collective mesenchymal migration. t.co/t0acs8hkkx

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